trifluoperazine-2684 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the trifluoperazine-2684 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1C4 aldo-keto reductase family 1, member C4
ANXA2 annexin A2
ANXA2P2 annexin A2 pseudogene 2
ASPH aspartate beta-hydroxylase
AXL AXL receptor tyrosine kinase
C11ORF63 chromosome 11 open reading frame 63
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD83 CD83 molecule
CLCA2 chloride channel accessory 2
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CREM cAMP responsive element modulator
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DIXDC1 DIX domain containing 1
DKK2 dickkopf WNT signaling pathway inhibitor 2
DZIP3 DAZ interacting zinc finger protein 3
EGR2 early growth response 2
EGR3 early growth response 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F5 coagulation factor V (proaccelerin, labile factor)
FAM114A1 family with sequence similarity 114, member A1
FLOT1 flotillin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GBP2 guanylate binding protein 2, interferon-inducible
GLP1R glucagon-like peptide 1 receptor
HOXA7 homeobox A7
IER3 immediate early response 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
IL24 interleukin 24
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDSR 3-ketodihydrosphingosine reductase
KLF2 Kruppel-like factor 2
KMT2A lysine (K)-specific methyltransferase 2A
KYNU kynureninase
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAGEB4 melanoma antigen family B4
MAPK7 mitogen-activated protein kinase 7
MLLT4-AS1 MLLT4 antisense RNA 1 (head to head)
MTUS1 microtubule associated tumor suppressor 1
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NDOR1 NADPH dependent diflavin oxidoreductase 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NOV nephroblastoma overexpressed
NR2E3 nuclear receptor subfamily 2, group E, member 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRP2 neuropilin 2
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4DIP phosphodiesterase 4D interacting protein
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PHACTR1 phosphatase and actin regulator 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB40A RAB40A, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RARG retinoic acid receptor, gamma
RCAN1 regulator of calcineurin 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RRBP1 ribosome binding protein 1
RS1 retinoschisin 1
RUFY3 RUN and FYVE domain containing 3
SCN11A sodium channel, voltage gated, type XI alpha subunit
SGK1 serum/glucocorticoid regulated kinase 1
SPP1 secreted phosphoprotein 1
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STX11 syntaxin 11
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESK1 testis-specific kinase 1
TGFBR3 transforming growth factor, beta receptor III
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TUBB2A tubulin, beta 2A class IIa
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
USP6NL USP6 N-terminal like
VCAN versican
VPS9D1 VPS9 domain containing 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACAD10 acyl-CoA dehydrogenase family, member 10
ADGB androglobin
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ANKRD55 ankyrin repeat domain 55
ARRB1 arrestin, beta 1
ATAT1 alpha tubulin acetyltransferase 1
C11ORF30 chromosome 11 open reading frame 30
C1QTNF3 C1q and tumor necrosis factor related protein 3
C8A complement component 8, alpha polypeptide
C8ORF44 chromosome 8 open reading frame 44
C9ORF9 chromosome 9 open reading frame 9
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCR2 chemokine (C-C motif) receptor 2
CD101 CD101 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST10 carbohydrate sulfotransferase 10
CRELD1 cysteine-rich with EGF-like domains 1
CTSG cathepsin G
DNA2 DNA replication helicase/nuclease 2
DNM3 dynamin 3
DOC2A double C2-like domains, alpha
DPEP2 dipeptidase 2
DTX2 deltex 2, E3 ubiquitin ligase
ERCC2 excision repair cross-complementation group 2
EXOSC1 exosome component 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM127B family with sequence similarity 127, member B
FAM222B family with sequence similarity 222, member B
FAM46A family with sequence similarity 46, member A
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FHIT fragile histidine triad
FMNL1 formin-like 1
FZD4 frizzled class receptor 4
GFI1 growth factor independent 1 transcription repressor
GNG4 guanine nucleotide binding protein (G protein), gamma 4
HIST1H1E histone cluster 1, H1e
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IFT140 intraflagellar transport 140
IL1B interleukin 1, beta
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
KDM8 lysine (K)-specific demethylase 8
KLF3 Kruppel-like factor 3 (basic)
L2HGDH L-2-hydroxyglutarate dehydrogenase
LIMD2 LIM domain containing 2
MAPKBP1 mitogen-activated protein kinase binding protein 1
MCRS1 microspherule protein 1
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MMP9 matrix metallopeptidase 9
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
NCKAP1L NCK-associated protein 1-like
NFE2 nuclear factor, erythroid 2
NKX3-2 NK3 homeobox 2
NOD1 nucleotide-binding oligomerization domain containing 1
NPFFR1 neuropeptide FF receptor 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PADI2 peptidyl arginine deiminase, type II
PDLIM2 PDZ and LIM domain 2 (mystique)
PDZD7 PDZ domain containing 7
PGP phosphoglycolate phosphatase
PRDM12 PR domain containing 12
PRICKLE3 prickle homolog 3 (Drosophila)
PSKH1 protein serine kinase H1
PXMP4 peroxisomal membrane protein 4, 24kDa
PYCRL pyrroline-5-carboxylate reductase-like
PYGB phosphorylase, glycogen; brain
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPUSD2 RNA pseudouridylate synthase domain containing 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SALL2 spalt-like transcription factor 2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCN10A sodium channel, voltage gated, type X alpha subunit
SERGEF secretion regulating guanine nucleotide exchange factor
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SYTL2 synaptotagmin-like 2
TET3 tet methylcytosine dioxygenase 3
THBS3 thrombospondin 3
THRAP3 thyroid hormone receptor associated protein 3
TLR1 toll-like receptor 1
TMEM53 transmembrane protein 53
TMEM62 transmembrane protein 62
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TPM3 tropomyosin 3
UBQLN4 ubiquilin 4
UNC13A unc-13 homolog A (C. elegans)
VN1R1 vomeronasal 1 receptor 1
VNN1 vanin 1
ZBED8 zinc finger, BED-type containing 8
ZNF76 zinc finger protein 76
ZNHIT2 zinc finger, HIT-type containing 2