trifluoperazine-4448 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the trifluoperazine-4448 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN2 actinin, alpha 2
AMIGO2 adhesion molecule with Ig-like domain 2
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
ARC activity-regulated cytoskeleton-associated protein
ATF3 activating transcription factor 3
ATG10 autophagy related 10
ATHL1 ATH1, acid trehalase-like 1 (yeast)
C10ORF10 chromosome 10 open reading frame 10
C20ORF195 chromosome 20 open reading frame 195
CA5B carbonic anhydrase VB, mitochondrial
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CARTPT CART prepropeptide
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDON cell adhesion associated, oncogene regulated
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLSTN3 calsyntenin 3
CNTD2 cyclin N-terminal domain containing 2
CSPG4 chondroitin sulfate proteoglycan 4
CTSS cathepsin S
CXCL3 chemokine (C-X-C motif) ligand 3
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DGKE diacylglycerol kinase, epsilon 64kDa
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSC2 desmocollin 2
DUSP1 dual specificity phosphatase 1
EFNA5 ephrin-A5
EPHA5 EPH receptor A5
ESR2 estrogen receptor 2 (ER beta)
GK glycerol kinase
GPR182 G protein-coupled receptor 182
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGHMBP2 immunoglobulin mu binding protein 2
IL15 interleukin 15
IL24 interleukin 24
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
JUND jun D proto-oncogene
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KLF13 Kruppel-like factor 13
KLHL24 kelch-like family member 24
KLK8 kallikrein-related peptidase 8
KRT16 keratin 16, type I
KRT34 keratin 34, type I
LAMP1 lysosomal-associated membrane protein 1
LEF1 lymphoid enhancer-binding factor 1
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MAP7D3 MAP7 domain containing 3
MEGF9 multiple EGF-like-domains 9
MIER2 mesoderm induction early response 1, family member 2
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MMP10 matrix metallopeptidase 10
MT1HL1 metallothionein 1H-like 1
NCAPH2 non-SMC condensin II complex, subunit H2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NUPR1 nuclear protein, transcriptional regulator, 1
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
POU6F2 POU class 6 homeobox 2
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRDM1 PR domain containing 1, with ZNF domain
PRDM14 PR domain containing 14
PRKG1 protein kinase, cGMP-dependent, type I
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRR protein tyrosine phosphatase, receptor type, R
RAB30 RAB30, member RAS oncogene family
RGR retinal G protein coupled receptor
RGS4 regulator of G-protein signaling 4
RND1 Rho family GTPase 1
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIX3 SIX homeobox 3
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SQSTM1 sequestosome 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TP53I11 tumor protein p53 inducible protein 11
TPM1 tropomyosin 1 (alpha)
TRIB3 tribbles pseudokinase 3
TSC2 tuberous sclerosis 2
VPRBP Vpr (HIV-1) binding protein
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZNF343 zinc finger protein 343
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ASAP1-IT1 ASAP1 intronic transcript 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BMPR1B bone morphogenetic protein receptor, type IB
C19ORF40 chromosome 19 open reading frame 40
C9ORF40 chromosome 9 open reading frame 40
CA5BP1 carbonic anhydrase VB pseudogene 1
CCDC106 coiled-coil domain containing 106
CCDC85C coiled-coil domain containing 85C
CD68 CD68 molecule
CD82 CD82 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP295 centrosomal protein 295kDa
CFAP45 cilia and flagella associated protein 45
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNTN1 contactin 1
CNTNAP3B contactin associated protein-like 3B
CPNE7 copine VII
CSF1R colony stimulating factor 1 receptor
CUL9 cullin 9
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DBF4B DBF4 zinc finger B
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EDAR ectodysplasin A receptor
EFNB1 ephrin-B1
EPN3 epsin 3
FKBP5 FK506 binding protein 5
GLB1L2 galactosidase, beta 1-like 2
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPNMB glycoprotein (transmembrane) nmb
GPRASP1 G protein-coupled receptor associated sorting protein 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST2H2AA3 histone cluster 2, H2aa3
HOXB2 homeobox B2
HSF2BP heat shock transcription factor 2 binding protein
IL12RB1 interleukin 12 receptor, beta 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
INO80D INO80 complex subunit D
INPP5J inositol polyphosphate-5-phosphatase J
IQSEC2 IQ motif and Sec7 domain 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCTD17 potassium channel tetramerization domain containing 17
KIFC3 kinesin family member C3
LIME1 Lck interacting transmembrane adaptor 1
LMNB1 lamin B1
LOC730101 uncharacterized LOC730101
LRRC61 leucine rich repeat containing 61
MBTPS2 membrane-bound transcription factor peptidase, site 2
MGC12488
MGP matrix Gla protein
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MUC3A mucin 3A, cell surface associated
NDP Norrie disease (pseudoglioma)
NOL6 nucleolar protein 6 (RNA-associated)
NTSR1 neurotensin receptor 1 (high affinity)
OGDHL oxoglutarate dehydrogenase-like
ORC1 origin recognition complex, subunit 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PADI1 peptidyl arginine deiminase, type I
PER3 period circadian clock 3
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PLA1A phospholipase A1 member A
PQLC2 PQ loop repeat containing 2
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
SCAF4 SR-related CTD-associated factor 4
SERGEF secretion regulating guanine nucleotide exchange factor
SIRAL2 SIR2 antiphage like 2
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC46A3 solute carrier family 46, member 3
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SMO smoothened, frizzled class receptor
SNRPN small nuclear ribonucleoprotein polypeptide N
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM206 transmembrane protein 206
TRAPPC13 trafficking protein particle complex 13
TSNAXIP1 translin-associated factor X interacting protein 1
TUBA4B tubulin, alpha 4b
UGT8 UDP glycosyltransferase 8
UNG uracil-DNA glycosylase
VGF VGF nerve growth factor inducible
WDR25 WD repeat domain 25
YOD1 YOD1 deubiquitinase
YY2 YY2 transcription factor
ZNF10 zinc finger protein 10
ZNF219 zinc finger protein 219
ZNF253 zinc finger protein 253
ZNF286A zinc finger protein 286A
ZNF492 zinc finger protein 492
ZNF639 zinc finger protein 639
ZNF702P zinc finger protein 702, pseudogene
ZNF747 zinc finger protein 747
ZNF76 zinc finger protein 76
ZSCAN31 zinc finger and SCAN domain containing 31