trifluoperazine-5442 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the trifluoperazine-5442 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACOT11 acyl-CoA thioesterase 11
ACRV1 acrosomal vesicle protein 1
ADAM8 ADAM metallopeptidase domain 8
ADGRG1 adhesion G protein-coupled receptor G1
ALOX15 arachidonate 15-lipoxygenase
ANKH ANKH inorganic pyrophosphate transport regulator
AQP3 aquaporin 3 (Gill blood group)
ARMCX4 armadillo repeat containing, X-linked 4
ATN1 atrophin 1
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
C11ORF21 chromosome 11 open reading frame 21
C16ORF45 chromosome 16 open reading frame 45
CABP2 calcium binding protein 2
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CDK6 cyclin-dependent kinase 6
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEMIP cell migration inducing protein, hyaluronan binding
CEP41 centrosomal protein 41kDa
CGA glycoprotein hormones, alpha polypeptide
CLSTN3 calsyntenin 3
COL1A1 collagen, type I, alpha 1
CRYGC crystallin, gamma C
DCAF4 DDB1 and CUL4 associated factor 4
DPP6 dipeptidyl-peptidase 6
DUSP4 dual specificity phosphatase 4
E2F5 E2F transcription factor 5, p130-binding
EGFR epidermal growth factor receptor
EGR1 early growth response 1
FADS3 fatty acid desaturase 3
FN1 fibronectin 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GAL3ST4 galactose-3-O-sulfotransferase 4
GH1 growth hormone 1
GREB1 growth regulation by estrogen in breast cancer 1
HMOX1 heme oxygenase 1
IGHD immunoglobulin heavy constant delta
IL9R interleukin 9 receptor
IQSEC2 IQ motif and Sec7 domain 2
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD7 potassium channel tetramerization domain containing 7
KDM8 lysine (K)-specific demethylase 8
KIAA0319L KIAA0319-like
KLHL24 kelch-like family member 24
KMT2A lysine (K)-specific methyltransferase 2A
LIME1 Lck interacting transmembrane adaptor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGIX MAGI family member, X-linked
MALL mal, T-cell differentiation protein-like
MKL1 megakaryoblastic leukemia (translocation) 1
MRPS12 mitochondrial ribosomal protein S12
MT1F metallothionein 1F
MT3 metallothionein 3
MTSS1L metastasis suppressor 1-like
MYL10 myosin, light chain 10, regulatory
MYL4 myosin, light chain 4, alkali; atrial, embryonic
N4BP2L1 NEDD4 binding protein 2-like 1
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NPIPB15 nuclear pore complex interacting protein family, member B15
NUPR1 nuclear protein, transcriptional regulator, 1
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PAX7 paired box 7
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRB1 proline-rich protein BstNI subfamily 1
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRMT8 protein arginine methyltransferase 8
PRSS53 protease, serine, 53
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RFC1 replication factor C (activator 1) 1, 145kDa
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RXRB retinoid X receptor, beta
SECTM1 secreted and transmembrane 1
SERHL2 serine hydrolase-like 2
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SNX1 sorting nexin 1
SOX2 SRY (sex determining region Y)-box 2
SPAG6 sperm associated antigen 6
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
STARD3 StAR-related lipid transfer (START) domain containing 3
SV2C synaptic vesicle glycoprotein 2C
SYNE1 spectrin repeat containing, nuclear envelope 1
TBX1 T-box 1
TBX5 T-box 5
TCF25 transcription factor 25 (basic helix-loop-helix)
TIMP3 TIMP metallopeptidase inhibitor 3
TLR2 toll-like receptor 2
TMPRSS2 transmembrane protease, serine 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNNT3 troponin T type 3 (skeletal, fast)
VCL vinculin
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
WDTC1 WD and tetratricopeptide repeats 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZNF280A zinc finger protein 280A
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ACTL8 actin-like 8
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ARL15 ADP-ribosylation factor-like 15
ARRB1 arrestin, beta 1
C19ORF40 chromosome 19 open reading frame 40
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C2ORF54 chromosome 2 open reading frame 54
C4ORF29 chromosome 4 open reading frame 29
C5 complement component 5
C8ORF60 chromosome 8 open reading frame 60
CA5BP1 carbonic anhydrase VB pseudogene 1
CAPN5 calpain 5
CBX8 chromobox homolog 8
CCNE2 cyclin E2
CEP97 centrosomal protein 97kDa
CHML choroideremia-like (Rab escort protein 2)
CIDEC cell death-inducing DFFA-like effector c
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CTAGE5 CTAGE family, member 5
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DUSP2 dual specificity phosphatase 2
EFNA3 ephrin-A3
ERN2 endoplasmic reticulum to nucleus signaling 2
FANCC Fanconi anemia, complementation group C
FBXL6 F-box and leucine-rich repeat protein 6
FGD1 FYVE, RhoGEF and PH domain containing 1
FLJ11710 uncharacterized protein FLJ11710
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GLB1L2 galactosidase, beta 1-like 2
GLRA1 glycine receptor, alpha 1
GMPR guanosine monophosphate reductase
GPALPP1 GPALPP motifs containing 1
GPX2 glutathione peroxidase 2
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2I general transcription factor IIi
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2AI histone cluster 1, H2ai
HIST1H3E histone cluster 1, H3e
HIST1H4C histone cluster 1, H4c
HIST1H4D histone cluster 1, H4d
HP1BP3 heterochromatin protein 1, binding protein 3
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IFT81 intraflagellar transport 81
IL15RA interleukin 15 receptor, alpha
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCTD20 potassium channel tetramerization domain containing 20
KIAA0754 KIAA0754
LINC00597 long intergenic non-protein coding RNA 597
LOC100286895 cell division cycle 27 homolog pseudogene
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPKBP1 mitogen-activated protein kinase binding protein 1
MED15 mediator complex subunit 15
MGC12488
MMD monocyte to macrophage differentiation-associated
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL41 mitochondrial ribosomal protein L41
MRPS18C mitochondrial ribosomal protein S18C
MTERF1 mitochondrial transcription termination factor 1
MTRF1 mitochondrial translational release factor 1
NPFFR1 neuropeptide FF receptor 1
NT5C 5', 3'-nucleotidase, cytosolic
OGFRL1 opioid growth factor receptor-like 1
PCDHB13 protocadherin beta 13
PDE8B phosphodiesterase 8B
PER3 period circadian clock 3
PHC1 polyhomeotic homolog 1 (Drosophila)
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLD2 phospholipase D2
POLH polymerase (DNA directed), eta
POMT2 protein-O-mannosyltransferase 2
PRKCE protein kinase C, epsilon
PRODH proline dehydrogenase (oxidase) 1
PRR4 proline rich 4 (lacrimal)
RAB28 RAB28, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RNF170 ring finger protein 170
RNF2 ring finger protein 2
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SKI SKI proto-oncogene
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPRYD7 SPRY domain containing 7
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAOK1 TAO kinase 1
TESC tescalcin
TET3 tet methylcytosine dioxygenase 3
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM242 transmembrane protein 242
TMEM39B transmembrane protein 39B
TRPV6 transient receptor potential cation channel, subfamily V, member 6
VGF VGF nerve growth factor inducible
ZNF492 zinc finger protein 492