trifluoperazine-5584 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the trifluoperazine-5584 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
AMT aminomethyltransferase
APC adenomatous polyposis coli
AQP3 aquaporin 3 (Gill blood group)
ARG1 arginase 1
ARTN artemin
ASCL1 achaete-scute family bHLH transcription factor 1
ATF3 activating transcription factor 3
ATXN7L1 ataxin 7-like 1
BIRC3 baculoviral IAP repeat containing 3
CA5B carbonic anhydrase VB, mitochondrial
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CEMIP cell migration inducing protein, hyaluronan binding
CHRND cholinergic receptor, nicotinic, delta (muscle)
CLGN calmegin
CSF1R colony stimulating factor 1 receptor
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DGCR14 DiGeorge syndrome critical region gene 14
DKFZP434C153 DKFZP434C153 protein
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DUSP4 dual specificity phosphatase 4
E2F5 E2F transcription factor 5, p130-binding
EGR1 early growth response 1
EGR3 early growth response 3
ELAVL3 ELAV like neuron-specific RNA binding protein 3
FADS3 fatty acid desaturase 3
FAM46C family with sequence similarity 46, member C
FAM76A family with sequence similarity 76, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FOS FBJ murine osteosarcoma viral oncogene homolog
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GREB1 growth regulation by estrogen in breast cancer 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDI2-AS1 IDI2 antisense RNA 1
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAG1 jagged 1
JUN jun proto-oncogene
KDM4B lysine (K)-specific demethylase 4B
KIDINS220 kinase D-interacting substrate, 220kDa
KLHL24 kelch-like family member 24
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCF2L MCF.2 cell line derived transforming sequence-like
MEP1B meprin A, beta
METTL7A methyltransferase like 7A
MIA3 melanoma inhibitory activity family, member 3
MLXIP MLX interacting protein
MOB3B MOB kinase activator 3B
N4BP2L2 NEDD4 binding protein 2-like 2
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NUDCD3 NudC domain containing 3
OLFM1 olfactomedin 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCBP2 poly(rC) binding protein 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKNOX2 PBX/knotted 1 homeobox 2
PLXNA2 plexin A2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PTAFR platelet-activating factor receptor
RNASE4 ribonuclease, RNase A family, 4
RPLP2 ribosomal protein, large, P2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAF4 SR-related CTD-associated factor 4
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SGPL1 sphingosine-1-phosphate lyase 1
SH3BP2 SH3-domain binding protein 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SOX9 SRY (sex determining region Y)-box 9
STS steroid sulfatase (microsomal), isozyme S
SYBU syntabulin (syntaxin-interacting)
TIMP3 TIMP metallopeptidase inhibitor 3
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRBC1 T cell receptor beta constant 1
TRIM2 tripartite motif containing 2
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
ANXA2P3 annexin A2 pseudogene 3
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARRB1 arrestin, beta 1
ASPN asporin
ATP10D ATPase, class V, type 10D
C1ORF159 chromosome 1 open reading frame 159
C5AR2 complement component 5a receptor 2
CA5BP1 carbonic anhydrase VB pseudogene 1
CBX8 chromobox homolog 8
CCDC85C coiled-coil domain containing 85C
CCDC9 coiled-coil domain containing 9
CCP110 centriolar coiled coil protein 110kDa
CD1A CD1a molecule
CD82 CD82 molecule
CFD complement factor D (adipsin)
CLDN15 claudin 15
CLDN9 claudin 9
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CORO7 coronin 7
CRY2 cryptochrome circadian clock 2
DOK5 docking protein 5
DUSP13 dual specificity phosphatase 13
EFNA3 ephrin-A3
EXD3 exonuclease 3'-5' domain containing 3
FGD1 FYVE, RhoGEF and PH domain containing 1
FLJ21369 uncharacterized protein FLJ21369
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLB1L galactosidase, beta 1-like
GMPR guanosine monophosphate reductase
HAMP hepcidin antimicrobial peptide
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOXA4 homeobox A4
HPS6 Hermansky-Pudlak syndrome 6
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IL2 interleukin 2
IQCC IQ motif containing C
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNIP1 Kv channel interacting protein 1
KCNK10 potassium channel, two pore domain subfamily K, member 10
KITLG KIT ligand
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIME1 Lck interacting transmembrane adaptor 1
LIN7A lin-7 homolog A (C. elegans)
LRP2 low density lipoprotein receptor-related protein 2
MAP1S microtubule-associated protein 1S
MAPKBP1 mitogen-activated protein kinase binding protein 1
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MSI1 musashi RNA-binding protein 1
MVP major vault protein
NACA2 nascent polypeptide-associated complex alpha subunit 2
OCA2 oculocutaneous albinism II
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PACS1 phosphofurin acidic cluster sorting protein 1
PADI1 peptidyl arginine deiminase, type I
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PGBD5 piggyBac transposable element derived 5
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLCD1 phospholipase C, delta 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLSCR4 phospholipid scramblase 4
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRF1 perforin 1 (pore forming protein)
PROL1 proline rich, lacrimal 1
PRSS53 protease, serine, 53
PTPRS protein tyrosine phosphatase, receptor type, S
REM1 RAS (RAD and GEM)-like GTP-binding 1
RGS20 regulator of G-protein signaling 20
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHBG Rh family, B glycoprotein (gene/pseudogene)
RHOBTB2 Rho-related BTB domain containing 2
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF126P1 ring finger protein 126 pseudogene 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SIPA1 signal-induced proliferation-associated 1
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SLPI secretory leukocyte peptidase inhibitor
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOX12 SRY (sex determining region Y)-box 12
SSBP3 single stranded DNA binding protein 3
STAG3 stromal antigen 3
TBC1D19 TBC1 domain family, member 19
TCTN1 tectonic family member 1
TEX40 testis expressed 40
TGFBR3 transforming growth factor, beta receptor III
THNSL2 threonine synthase-like 2 (S. cerevisiae)
THRAP3 thyroid hormone receptor associated protein 3
TMOD1 tropomodulin 1
TRAIP TRAF interacting protein
TRPV6 transient receptor potential cation channel, subfamily V, member 6
XYLT2 xylosyltransferase II
ZNF16 zinc finger protein 16
ZNF205 zinc finger protein 205