trifluoperazine-7420 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the trifluoperazine-7420 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANKRD12 ankyrin repeat domain 12
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ARRB1 arrestin, beta 1
ATF3 activating transcription factor 3
C14ORF93 chromosome 14 open reading frame 93
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDON cell adhesion associated, oncogene regulated
CEMIP cell migration inducing protein, hyaluronan binding
CGA glycoprotein hormones, alpha polypeptide
CHKB choline kinase beta
CTAGE9 CTAGE family, member 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DST dystonin
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
FAM65A family with sequence similarity 65, member A
FBXL2 F-box and leucine-rich repeat protein 2
FCMR Fc fragment of IgM receptor
FLCN folliculin
FOS FBJ murine osteosarcoma viral oncogene homolog
GEM GTP binding protein overexpressed in skeletal muscle
GGT1 gamma-glutamyltransferase 1
GOLGA2 golgin A2
GRB10 growth factor receptor-bound protein 10
HBP1 HMG-box transcription factor 1
HOXA4 homeobox A4
HSF1 heat shock transcription factor 1
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
INSIG1 insulin induced gene 1
INSR insulin receptor
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KDM5A lysine (K)-specific demethylase 5A
KHNYN KH and NYN domain containing
KIAA0430 KIAA0430
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KLHL28 kelch-like family member 28
KRT15 keratin 15, type I
LOC730101 uncharacterized LOC730101
LONP2 lon peptidase 2, peroxisomal
LPIN1 lipin 1
LYRM9 LYR motif containing 9
LZTFL1 leucine zipper transcription factor-like 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A2 mannosidase, alpha, class 1A, member 2
MAP2 microtubule-associated protein 2
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAST3 microtubule associated serine/threonine kinase 3
MAST4 microtubule associated serine/threonine kinase family member 4
MCF2L MCF.2 cell line derived transforming sequence-like
MID1 midline 1
MSI1 musashi RNA-binding protein 1
MXD3 MAX dimerization protein 3
MZF1 myeloid zinc finger 1
NDE1 nudE neurodevelopment protein 1
NDRG1 N-myc downstream regulated 1
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PHF20L1 PHD finger protein 20-like 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLCD1 phospholipase C, delta 1
POFUT1 protein O-fucosyltransferase 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RASAL1 RAS protein activator like 1 (GAP1 like)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SAT1 spermidine/spermine N1-acetyltransferase 1
SIK3 SIK family kinase 3
SLC38A7 solute carrier family 38, member 7
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMC4 structural maintenance of chromosomes 4
SOS2 son of sevenless homolog 2 (Drosophila)
SOX12 SRY (sex determining region Y)-box 12
SREBF2 sterol regulatory element binding transcription factor 2
SUN1 Sad1 and UNC84 domain containing 1
TEP1 telomerase-associated protein 1
TESK2 testis-specific kinase 2
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRIM2 tripartite motif containing 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UPP1 uridine phosphorylase 1
WDR45 WD repeat domain 45
WDR62 WD repeat domain 62
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZER1 zyg-11 related, cell cycle regulator

decreased expression

Symbol Name
AARSD1 alanyl-tRNA synthetase domain containing 1
ABHD14A abhydrolase domain containing 14A
AHCTF1 AT hook containing transcription factor 1
ANKRD28 ankyrin repeat domain 28
ARHGAP11A Rho GTPase activating protein 11A
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ASB8 ankyrin repeat and SOCS box containing 8
ATAD5 ATPase family, AAA domain containing 5
BRD9 bromodomain containing 9
C17ORF62 chromosome 17 open reading frame 62
C17ORF70 chromosome 17 open reading frame 70
C19ORF40 chromosome 19 open reading frame 40
C21ORF91 chromosome 21 open reading frame 91
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCDC25 coiled-coil domain containing 25
CCDC85C coiled-coil domain containing 85C
CCDC86 coiled-coil domain containing 86
CCND3 cyclin D3
CDC20 cell division cycle 20
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP6 charged multivesicular body protein 6
CTPS1 CTP synthase 1
CYB561D2 cytochrome b561 family, member D2
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DVL1 dishevelled segment polarity protein 1
ERCC3 excision repair cross-complementation group 3
ETAA1 Ewing tumor-associated antigen 1
FANCC Fanconi anemia, complementation group C
FKBP5 FK506 binding protein 5
FNTB farnesyltransferase, CAAX box, beta
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
GPR19 G protein-coupled receptor 19
GRWD1 glutamate-rich WD repeat containing 1
GSTM2 glutathione S-transferase mu 2 (muscle)
HEATR3 HEAT repeat containing 3
HP1BP3 heterochromatin protein 1, binding protein 3
IER3IP1 immediate early response 3 interacting protein 1
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IPO8 importin 8
KATNBL1 katanin p80 subunit B-like 1
KCTD20 potassium channel tetramerization domain containing 20
KIAA0125 KIAA0125
LYPD1 LY6/PLAUR domain containing 1
LZTR1 leucine-zipper-like transcription regulator 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MED24 mediator complex subunit 24
MLYCD malonyl-CoA decarboxylase
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MRPL44 mitochondrial ribosomal protein L44
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NUPL2 nucleoporin like 2
OGFRL1 opioid growth factor receptor-like 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PARG poly (ADP-ribose) glycohydrolase
PCSK7 proprotein convertase subtilisin/kexin type 7
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHO1 pleckstrin homology domain containing, family O member 1
PMM2 phosphomannomutase 2
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
PP14571 uncharacterized LOC100130449
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
PYCRL pyrroline-5-carboxylate reductase-like
RAB32 RAB32, member RAS oncogene family
RAI14 retinoic acid induced 14
RBL1 retinoblastoma-like 1
RBM38 RNA binding motif protein 38
RCOR3 REST corepressor 3
RPP40 ribonuclease P/MRP 40kDa subunit
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SFT2D2 SFT2 domain containing 2
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SH2D4A SH2 domain containing 4A
SLC16A6 solute carrier family 16, member 6
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SNHG3 small nucleolar RNA host gene 3
SPATA2L spermatogenesis associated 2-like
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TBL3 transducin (beta)-like 3
TMEM110 transmembrane protein 110
TPST1 tyrosylprotein sulfotransferase 1
TRAF5 TNF receptor-associated factor 5
TRIM25 tripartite motif containing 25
TUBGCP5 tubulin, gamma complex associated protein 5
ULBP2 UL16 binding protein 2
UNKL unkempt family zinc finger-like
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZCCHC2 zinc finger, CCHC domain containing 2
ZNF286A zinc finger protein 286A
ZNF574 zinc finger protein 574