trifluridine-3559 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the trifluridine-3559 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ACPP acid phosphatase, prostate
ADGRE1 adhesion G protein-coupled receptor E1
AIF1 allograft inflammatory factor 1
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
BDKRB2 bradykinin receptor B2
BLNK B-cell linker
BMP1 bone morphogenetic protein 1
BTG2 BTG family, member 2
C10ORF95 chromosome 10 open reading frame 95
C11ORF21 chromosome 11 open reading frame 21
C17ORF80 chromosome 17 open reading frame 80
C1QTNF1 C1q and tumor necrosis factor related protein 1
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CAMK1 calcium/calmodulin-dependent protein kinase I
CCNG2 cyclin G2
CDC14A cell division cycle 14A
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEL carboxyl ester lipase
CFAP69 cilia and flagella associated protein 69
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EFNB3 ephrin-B3
EGFR epidermal growth factor receptor
EPHB2 EPH receptor B2
ERC2-IT1 ERC2 intronic transcript 1
FADS3 fatty acid desaturase 3
FAS Fas cell surface death receptor
FOXO4 forkhead box O4
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GADD45A growth arrest and DNA-damage-inducible, alpha
GK3P glycerol kinase 3 pseudogene
GPER1 G protein-coupled estrogen receptor 1
GPR87 G protein-coupled receptor 87
GPRASP1 G protein-coupled receptor associated sorting protein 1
HDAC11 histone deacetylase 11
HIST1H2BO histone cluster 1, H2bo
IFNG interferon, gamma
INHBE inhibin, beta E
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KIAA0513 KIAA0513
KLF9 Kruppel-like factor 9
KLHL22 kelch-like family member 22
LEPR leptin receptor
LIF leukemia inhibitory factor
LIMK2 LIM domain kinase 2
MAP2 microtubule-associated protein 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MYOF myoferlin
NF1 neurofibromin 1
NMT2 N-myristoyltransferase 2
NUPR1 nuclear protein, transcriptional regulator, 1
OSMR oncostatin M receptor
OXTR oxytocin receptor
PADI3 peptidyl arginine deiminase, type III
PAX5 paired box 5
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLK3 polo-like kinase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PQBP1 polyglutamine binding protein 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RBFA ribosome binding factor A (putative)
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RGS20 regulator of G-protein signaling 20
RND1 Rho family GTPase 1
RNF19B ring finger protein 19B
SATB2 SATB homeobox 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SHOX2 short stature homeobox 2
SIPA1 signal-induced proliferation-associated 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLIT2 slit homolog 2 (Drosophila)
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRPK2 SRSF protein kinase 2
STK11 serine/threonine kinase 11
STOM stomatin
SVIL supervillin
TFEB transcription factor EB
TMCC2 transmembrane and coiled-coil domain family 2
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM144 transmembrane protein 144
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TP53I3 tumor protein p53 inducible protein 3
TTC38 tetratricopeptide repeat domain 38
VN1R1 vomeronasal 1 receptor 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZNF304 zinc finger protein 304
ZNF750 zinc finger protein 750

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
ALPK1 alpha-kinase 1
ANAPC2 anaphase promoting complex subunit 2
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
AXIN1 axin 1
BAHCC1 BAH domain and coiled-coil containing 1
BAHD1 bromo adjacent homology domain containing 1
BORA bora, aurora kinase A activator
C7ORF43 chromosome 7 open reading frame 43
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAMKMT calmodulin-lysine N-methyltransferase
CBX4 chromobox homolog 4
CBX8 chromobox homolog 8
CCNB1 cyclin B1
CCNO cyclin O
CCS copper chaperone for superoxide dismutase
CDC20 cell division cycle 20
CDK20 cyclin-dependent kinase 20
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CXADR coxsackie virus and adenovirus receptor
DEPDC1 DEP domain containing 1
DHDDS dehydrodolichyl diphosphate synthase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ENO3 enolase 3 (beta, muscle)
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FAM204A family with sequence similarity 204, member A
FAM64A family with sequence similarity 64, member A
FKBP10 FK506 binding protein 10, 65 kDa
FPGS folylpolyglutamate synthase
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
H1F0 H1 histone family, member 0
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H2AI histone cluster 1, H2ai
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H3B histone cluster 1, H3b
HIST1H4C histone cluster 1, H4c
HIST1H4F histone cluster 1, H4f
HJURP Holliday junction recognition protein
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC11 homeobox C11
INCENP inner centromere protein antigens 135/155kDa
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JMJD4 jumonji domain containing 4
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KLHL36 kelch-like family member 36
LHX1 LIM homeobox 1
LINC00115 long intergenic non-protein coding RNA 115
LOC729164 hCG1732469
LRRC20 leucine rich repeat containing 20
MAPKBP1 mitogen-activated protein kinase binding protein 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MTG1 mitochondrial ribosome-associated GTPase 1
NDC80 NDC80 kinetochore complex component
ODF2 outer dense fiber of sperm tails 2
PAGR1 PAXIP1 associated glutamate-rich protein 1
PLK1 polo-like kinase 1
POM121 POM121 transmembrane nucleoporin
PPAN peter pan homolog (Drosophila)
PPT2 palmitoyl-protein thioesterase 2
PSRC1 proline/serine-rich coiled-coil 1
PYCRL pyrroline-5-carboxylate reductase-like
QPCTL glutaminyl-peptide cyclotransferase-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
SCD5 stearoyl-CoA desaturase 5
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SIRT6 sirtuin 6
SLC12A8 solute carrier family 12, member 8
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
STK16 serine/threonine kinase 16
SULT4A1 sulfotransferase family 4A, member 1
SUN2 Sad1 and UNC84 domain containing 2
TACC3 transforming, acidic coiled-coil containing protein 3
TCTN1 tectonic family member 1
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TPX2 TPX2, microtubule-associated
TRABD TraB domain containing
TROAP trophinin associated protein
TUBA3D tubulin, alpha 3d
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UNC119 unc-119 homolog (C. elegans)
WDR4 WD repeat domain 4
WLS wntless Wnt ligand secretion mediator
ZNF205 zinc finger protein 205
ZNF804A zinc finger protein 804A