trifluridine-6136 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the trifluridine-6136 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ADARB1 adenosine deaminase, RNA-specific, B1
ADTRP androgen-dependent TFPI-regulating protein
AHNAK AHNAK nucleoprotein
AMACR alpha-methylacyl-CoA racemase
ANKH ANKH inorganic pyrophosphate transport regulator
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOC1 apolipoprotein C-I
ARL2BP ADP-ribosylation factor-like 2 binding protein
ARMCX4 armadillo repeat containing, X-linked 4
ASMT acetylserotonin O-methyltransferase
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCL6 B-cell CLL/lymphoma 6
BIRC3 baculoviral IAP repeat containing 3
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CCDC85C coiled-coil domain containing 85C
CD226 CD226 molecule
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CLCA2 chloride channel accessory 2
CLDN9 claudin 9
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CREM cAMP responsive element modulator
DLG5 discs, large homolog 5 (Drosophila)
DMRT1 doublesex and mab-3 related transcription factor 1
DMXL2 Dmx-like 2
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSTYK dual serine/threonine and tyrosine protein kinase
EMP2 epithelial membrane protein 2
ERN2 endoplasmic reticulum to nucleus signaling 2
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FBN1 fibrillin 1
FLT1 fms-related tyrosine kinase 1
FOSL2 FOS-like antigen 2
FRMD1 FERM domain containing 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GPC1 glypican 1
GPM6A glycoprotein M6A
GSPT1 G1 to S phase transition 1
HAMP hepcidin antimicrobial peptide
HOXA4 homeobox A4
HSPA1L heat shock 70kDa protein 1-like
ICA1 islet cell autoantigen 1, 69kDa
IL3RA interleukin 3 receptor, alpha (low affinity)
INHBA inhibin, beta A
IQSEC1 IQ motif and Sec7 domain 1
IRF5 interferon regulatory factor 5
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM2A lysine (K)-specific demethylase 2A
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KHK ketohexokinase (fructokinase)
KHSRP KH-type splicing regulatory protein
KIAA0125 KIAA0125
KIF24 kinesin family member 24
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MED25 mediator complex subunit 25
MIR22HG MIR22 host gene
MSI1 musashi RNA-binding protein 1
MSX2 msh homeobox 2
NEBL nebulette
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NRCAM neuronal cell adhesion molecule
NUP88 nucleoporin 88kDa
NXF2 nuclear RNA export factor 2
NXPH4 neurexophilin 4
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PDIA2 protein disulfide isomerase family A, member 2
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PIP prolactin-induced protein
PKNOX2 PBX/knotted 1 homeobox 2
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
RHAG Rh-associated glycoprotein
RNF25 ring finger protein 25
SIRPA signal-regulatory protein alpha
SLAMF7 SLAM family member 7
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLIT2 slit homolog 2 (Drosophila)
SPATA2L spermatogenesis associated 2-like
SUGP1 SURP and G patch domain containing 1
T T, brachyury homolog (mouse)
TBX10 T-box 10
TGFBI transforming growth factor, beta-induced, 68kDa
TMCC1 transmembrane and coiled-coil domain family 1
TMPRSS6 transmembrane protease, serine 6
TP53I11 tumor protein p53 inducible protein 11
TRIM2 tripartite motif containing 2
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSSK2 testis-specific serine kinase 2
WDR25 WD repeat domain 25
ZNF185 zinc finger protein 185 (LIM domain)
ZNF3 zinc finger protein 3

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ANKFY1 ankyrin repeat and FYVE domain containing 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BHLHE41 basic helix-loop-helix family, member e41
BPHL biphenyl hydrolase-like (serine hydrolase)
BSPRY B-box and SPRY domain containing
BTBD2 BTB (POZ) domain containing 2
C19ORF40 chromosome 19 open reading frame 40
C9ORF3 chromosome 9 open reading frame 3
CCL20 chemokine (C-C motif) ligand 20
CCNB1 cyclin B1
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDK3 cyclin-dependent kinase 3
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CDR2L cerebellar degeneration-related protein 2-like
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CIT citron rho-interacting serine/threonine kinase
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CRABP2 cellular retinoic acid binding protein 2
CRY2 cryptochrome circadian clock 2
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM86C1 family with sequence similarity 86, member C1
FBXL7 F-box and leucine-rich repeat protein 7
GLCE glucuronic acid epimerase
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GRAMD1B GRAM domain containing 1B
HIST1H1C histone cluster 1, H1c
HIST1H1E histone cluster 1, H1e
HIST1H2AC histone cluster 1, H2ac
HIST1H2AG histone cluster 1, H2ag
HIST1H4C histone cluster 1, H4c
HIST1H4J histone cluster 1, H4j
HMMR hyaluronan-mediated motility receptor (RHAMM)
HYAL2 hyaluronoglucosaminidase 2
IFI6 interferon, alpha-inducible protein 6
INF2 inverted formin, FH2 and WH2 domain containing
ITPKB inositol-trisphosphate 3-kinase B
KIAA0319L KIAA0319-like
KIAA1107 KIAA1107
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIFC1 kinesin family member C1
LINC00339 long intergenic non-protein coding RNA 339
LINC00597 long intergenic non-protein coding RNA 597
LOC390998 ribosomal protein L10 pseudogene
LOC730101 uncharacterized LOC730101
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP6D1 MAP6 domain containing 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MDM4 MDM4, p53 regulator
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MXD3 MAX dimerization protein 3
NACA2 nascent polypeptide-associated complex alpha subunit 2
NINJ2 ninjurin 2
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PLK1 polo-like kinase 1
POLM polymerase (DNA directed), mu
PPARG peroxisome proliferator-activated receptor gamma
PSRC1 proline/serine-rich coiled-coil 1
RAB35 RAB35, member RAS oncogene family
RASAL1 RAS protein activator like 1 (GAP1 like)
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
SCAI suppressor of cancer cell invasion
SCUBE3 signal peptide, CUB domain, EGF-like 3
SLC12A9 solute carrier family 12, member 9
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOGA1 suppressor of glucose, autophagy associated 1
SPATA7 spermatogenesis associated 7
STAG3L1 stromal antigen 3-like 1 (pseudogene)
SUN2 Sad1 and UNC84 domain containing 2
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TCTN1 tectonic family member 1
TMEM134 transmembrane protein 134
TMEM209 transmembrane protein 209
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAIP TRAF interacting protein
TROAP trophinin associated protein
TTC26 tetratricopeptide repeat domain 26
UBE2C ubiquitin-conjugating enzyme E2C
UBE2O ubiquitin-conjugating enzyme E2O
WDR91 WD repeat domain 91
ZBTB22 zinc finger and BTB domain containing 22
ZBTB38 zinc finger and BTB domain containing 38
ZFP37 ZFP37 zinc finger protein
ZMAT5 zinc finger, matrin-type 5
ZNF212 zinc finger protein 212
ZNF276 zinc finger protein 276
ZNF32 zinc finger protein 32
ZNF345 zinc finger protein 345
ZNF428 zinc finger protein 428
ZNF493 zinc finger protein 493