trigger Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

419 genes co-occuring with the biological term trigger in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABI3BP ABI family, member 3 (NESH) binding protein
ACE angiotensin I converting enzyme
ACVR1B activin A receptor, type IB
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADM adrenomedullin
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX15 arachidonate 15-lipoxygenase
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANPEP alanyl (membrane) aminopeptidase
ANTXR2 anthrax toxin receptor 2
AOC3 amine oxidase, copper containing 3
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOE apolipoprotein E
APOH apolipoprotein H (beta-2-glycoprotein I)
APP amyloid beta (A4) precursor protein
AQP1 aquaporin 1 (Colton blood group)
AQP7 aquaporin 7
AREG amphiregulin
ARHGAP1 Rho GTPase activating protein 1
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATXN3 ataxin 3
AURKA aurora kinase A
AVPR2 arginine vasopressin receptor 2
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BID BH3 interacting domain death agonist
BIRC2 baculoviral IAP repeat containing 2
BIRC6 baculoviral IAP repeat containing 6
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAPN10 calpain 10
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL26 chemokine (C-C motif) ligand 26
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CD1D CD1d molecule
CD1E CD1e molecule
CD300LB CD300 molecule-like family member b
CD38 CD38 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD46 CD46 molecule, complement regulatory protein
CD58 CD58 molecule
CDC20 cell division cycle 20
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDX2 caudal type homeobox 2
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFL1 cofilin 1 (non-muscle)
CHN1 chimerin 1
CLN3 ceroid-lipofuscinosis, neuronal 3
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CMKLR1 chemerin chemokine-like receptor 1
COIL coilin
COL10A1 collagen, type X, alpha 1
COL7A1 collagen, type VII, alpha 1
CPT2 carnitine palmitoyltransferase 2
CRELD2 cysteine-rich with EGF-like domains 2
CRH corticotropin releasing hormone
CRHR1 corticotropin releasing hormone receptor 1
CSPG4 chondroitin sulfate proteoglycan 4
CT45A1 cancer/testis antigen family 45, member A1
CTCF CCCTC-binding factor (zinc finger protein)
CTCFL CCCTC-binding factor (zinc finger protein)-like
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSD cathepsin D
CTSK cathepsin K
CTSL cathepsin L
CTTN cortactin
CUL4A cullin 4A
CUL4B cullin 4B
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT3 DNA-damage-inducible transcript 3
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEK DEK proto-oncogene
DGUOK deoxyguanosine kinase
DIABLO diablo, IAP-binding mitochondrial protein
DSG1 desmoglein 1
EEF2K eukaryotic elongation factor 2 kinase
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF1 eukaryotic translation initiation factor 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4B eukaryotic translation initiation factor 4B
EIF4E2 eukaryotic translation initiation factor 4E family member 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4H eukaryotic translation initiation factor 4H
EIF5 eukaryotic translation initiation factor 5
ELANE elastase, neutrophil expressed
ELAVL1 ELAV like RNA binding protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMILIN2 elastin microfibril interfacer 2
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EPO erythropoietin
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC3 excision repair cross-complementation group 3
ERCC4 excision repair cross-complementation group 4
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
F8 coagulation factor VIII, procoagulant component
FABP4 fatty acid binding protein 4, adipocyte
FADD Fas (TNFRSF6)-associated via death domain
FAS Fas cell surface death receptor
FBXO5 F-box protein 5
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FLT1 fms-related tyrosine kinase 1
FMR1 fragile X mental retardation 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FUS FUS RNA binding protein
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FXN frataxin
FYN FYN proto-oncogene, Src family tyrosine kinase
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA4 GATA binding protein 4
GBA glucosidase, beta, acid
GHSR growth hormone secretagogue receptor
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRH2 gonadotropin-releasing hormone 2
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GP6 glycoprotein VI (platelet)
GPBAR1 G protein-coupled bile acid receptor 1
GPER1 G protein-coupled estrogen receptor 1
GPI glucose-6-phosphate isomerase
GSK3B glycogen synthase kinase 3 beta
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HFE hemochromatosis
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK2 homeodomain interacting protein kinase 2
HIST3H2BB histone cluster 3, H2bb
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
HRK harakiri, BCL2 interacting protein
HSPA1A heat shock 70kDa protein 1A
HSPA4 heat shock 70kDa protein 4
HSPB1 heat shock 27kDa protein 1
HSPB2 heat shock 27kDa protein 2
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTT huntingtin
ICAM1 intercellular adhesion molecule 1
IDE insulin-degrading enzyme
IFI16 interferon, gamma-inducible protein 16
IFNA1 interferon, alpha 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IGHE immunoglobulin heavy constant epsilon
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10 interleukin 10
IL18 interleukin 18
IL1B interleukin 1, beta
IL2 interleukin 2
IL24 interleukin 24
IL27 interleukin 27
IL33 interleukin 33
IL37 interleukin 37
IL4 interleukin 4
INS insulin
IQGAP1 IQ motif containing GTPase activating protein 1
IRF3 interferon regulatory factor 3
IRF9 interferon regulatory factor 9
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAK1 Janus kinase 1
JAK2 Janus kinase 2
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNIP3 Kv channel interacting protein 3, calsenilin
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDR kinase insert domain receptor
KIF11 kinesin family member 11
KIN Kin17 DNA and RNA binding protein
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
KISS1 KiSS-1 metastasis-suppressor
KISS1R KISS1 receptor
KL klotho
KLK6 kallikrein-related peptidase 6
KLK7 kallikrein-related peptidase 7
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRT18 keratin 18, type I
LAG3 lymphocyte-activation gene 3
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAMA3 laminin, alpha 3
LEP leptin
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS8 lectin, galactoside-binding, soluble, 8
LGALS9 lectin, galactoside-binding, soluble, 9
LHCGR luteinizing hormone/choriogonadotropin receptor
LMNA lamin A/C
LMNB1 lamin B1
LRP1 low density lipoprotein receptor-related protein 1
MAD2L1BP MAD2L1 binding protein
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPT microtubule-associated protein tau
MARCO macrophage receptor with collagenous structure
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MBL2 mannose-binding lectin (protein C) 2, soluble
MBP myelin basic protein
MCHR1 melanin-concentrating hormone receptor 1
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MGP matrix Gla protein
MIR106B microRNA 106b
MIR192 microRNA 192
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMP9 matrix metallopeptidase 9
MPL MPL proto-oncogene, thrombopoietin receptor
MRC1 mannose receptor, C type 1
MSR1 macrophage scavenger receptor 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYL2 myosin, light chain 2, regulatory, cardiac, slow
NCAM1 neural cell adhesion molecule 1
NCK1 NCK adaptor protein 1
NCR2 natural cytotoxicity triggering receptor 2
NEB nebulin
NEBL nebulette
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1
NLRP3 NLR family, pyrin domain containing 3
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NOTCH3 notch 3
NOX1 NADPH oxidase 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR1I2 nuclear receptor subfamily 1, group I, member 2
NRP2 neuropilin 2
NT5E 5'-nucleotidase, ecto (CD73)
NUCLEOLIN nucleolin multifunctional protein
ORAI1 ORAI calcium release-activated calcium modulator 1
PABPC1 poly(A) binding protein, cytoplasmic 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PANK2 pantothenate kinase 2
PANX1 pannexin 1
PARK7 parkinson protein 7
PARP1 poly (ADP-ribose) polymerase 1
PDCD1 programmed cell death 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PERP PERP, TP53 apoptosis effector
PGR progesterone receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLD1 phospholipase D1, phosphatidylcholine-specific
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPARG peroxisome proliferator-activated receptor gamma
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRL prolactin
PRNP prion protein
PRTN3 proteinase 3
PSEN1 presenilin 1
PSEN2 presenilin 2
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PTGDR2 prostaglandin D2 receptor 2
PTGES prostaglandin E synthase
PTH parathyroid hormone
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
PTTG1 pituitary tumor-transforming 1
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBL2 retinoblastoma-like 2
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOA ras homolog family member A
RHOF ras homolog family member F (in filopodia)
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RSF1 remodeling and spacing factor 1
RTN3 reticulon 3
RYR2 ryanodine receptor 2 (cardiac)
S100A9 S100 calcium binding protein A9
SAMHD1 SAM domain and HD domain 1
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SDC1 syndecan 1
SDC4 syndecan 4
SELE selectin E
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SHH sonic hedgehog
SIAH1 siah E3 ubiquitin protein ligase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD2 SMAD family member 2
SMAD7 SMAD family member 7
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SON SON DNA binding protein
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SPAST spastin
SPP1 secreted phosphoprotein 1
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STAU1 staufen double-stranded RNA binding protein 1
SYK spleen tyrosine kinase
TAC1 tachykinin, precursor 1
TACR1 tachykinin receptor 1
TARDBP TAR DNA binding protein
TF transferrin
TFF2 trefoil factor 2
TFRC transferrin receptor
TG thyroglobulin
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TP73 tumor protein p73
TRB T cell receptor beta locus
TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TRPM5 transient receptor potential cation channel, subfamily M, member 5
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSLP thymic stromal lymphopoietin
TTR transthyretin
TWIST1 twist family bHLH transcription factor 1
UBE2E2 ubiquitin-conjugating enzyme E2E 2
UBE2K ubiquitin-conjugating enzyme E2K
UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VCP valosin containing protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WAPAL wings apart-like homolog (Drosophila)
WNK1 WNK lysine deficient protein kinase 1
WNT1 wingless-type MMTV integration site family, member 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZBP1 Z-DNA binding protein 1