triggering Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

305 genes co-occuring with the biological term triggering in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACHE acetylcholinesterase (Yt blood group)
ADAM17 ADAM metallopeptidase domain 17
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
AHR aryl hydrocarbon receptor
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA1 annexin A1
ANXA2 annexin A2
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APP amyloid beta (A4) precursor protein
ARHGAP24 Rho GTPase activating protein 24
ASF1A anti-silencing function 1A histone chaperone
ASF1B anti-silencing function 1B histone chaperone
ASXL1 additional sex combs like transcriptional regulator 1
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
AURKB aurora kinase B
AXIN1 axin 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BLNK B-cell linker
BSG basigin (Ok blood group)
BTN3A1 butyrophilin, subfamily 3, member A1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C3 complement component 3
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CALR calreticulin
CAMP cathelicidin antimicrobial peptide
CAPN2 calpain 2, (m/II) large subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCNB1 cyclin B1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD160 CD160 molecule
CD226 CD226 molecule
CD244 CD244 molecule, natural killer cell receptor 2B4
CD38 CD38 molecule
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CD63 CD63 molecule
CD80 CD80 molecule
CD81 CD81 molecule
CD86 CD86 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDX2 caudal type homeobox 2
CFLAR CASP8 and FADD-like apoptosis regulator
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGB chorionic gonadotropin, beta polypeptide
CLDN1 claudin 1
CLEC10A C-type lectin domain family 10, member A
CLEC4C C-type lectin domain family 4, member C
CLIC1 chloride intracellular channel 1
CLOCK clock circadian regulator
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRP C-reactive protein, pentraxin-related
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
DCN decorin
DCST2 DC-STAMP domain containing 2
DDIT3 DNA-damage-inducible transcript 3
DEPTOR DEP domain containing MTOR-interacting protein
DIABLO diablo, IAP-binding mitochondrial protein
DUOX2 dual oxidase 2
ECT2 epithelial cell transforming 2
EGFR epidermal growth factor receptor
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELN elastin
EPCAM epithelial cell adhesion molecule
EPO erythropoietin
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC6 excision repair cross-complementation group 6
ESR1 estrogen receptor 1
EXOC6 exocyst complex component 6
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FGF23 fibroblast growth factor 23
FKBP5 FK506 binding protein 5
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FOXP3 forkhead box P3
FPR1 formyl peptide receptor 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GATA2 GATA binding protein 2
GJA1 gap junction protein, alpha 1, 43kDa
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GPER1 G protein-coupled estrogen receptor 1
GPX1 glutathione peroxidase 1
GRM5 glutamate receptor, metabotropic 5
GSK3B glycogen synthase kinase 3 beta
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
HAVCR2 hepatitis A virus cellular receptor 2
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HMGB1 high mobility group box 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HOTAIR HOX transcript antisense RNA
HRAS Harvey rat sarcoma viral oncogene homolog
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTRA2 HtrA serine peptidase 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFIH1 interferon induced with helicase C domain 1
IFN1@ interferon, type 1, cluster
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP5 insulin-like growth factor binding protein 5
IHH indian hedgehog
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL10 interleukin 10
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL2 interleukin 2
IL25 interleukin 25
IL2RA interleukin 2 receptor, alpha
IL33 interleukin 33
IL5 interleukin 5
IL6 interleukin 6
INHBA inhibin, beta A
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JDP2 Jun dimerization protein 2
JUN jun proto-oncogene
KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KLRC2 killer cell lectin-like receptor subfamily C, member 2
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KNG1 kininogen 1
LDHB lactate dehydrogenase B
LEFTY2 left-right determination factor 2
LGMN legumain
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
MAF1 MAF1 homolog (S. cerevisiae)
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPT microtubule-associated protein tau
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MFN2 mitofusin 2
MGMT O-6-methylguanine-DNA methyltransferase
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MSN moesin
MTA1 metastasis associated 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
MYL9 myosin, light chain 9, regulatory
NAMPT nicotinamide phosphoribosyltransferase
NCR1 natural cytotoxicity triggering receptor 1
NCR2 natural cytotoxicity triggering receptor 2
NCR3 natural cytotoxicity triggering receptor 3
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NKX3-2 NK3 homeobox 2
NLRP1 NLR family, pyrin domain containing 1
NLRP3 NLR family, pyrin domain containing 3
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOD2 nucleotide-binding oligomerization domain containing 2
OPRM1 opioid receptor, mu 1
ORAI1 ORAI calcium release-activated calcium modulator 1
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
OTOF otoferlin
PAEP progestagen-associated endometrial protein
PARK7 parkinson protein 7
PDCD6IP programmed cell death 6 interacting protein
PECAM1 platelet/endothelial cell adhesion molecule 1
PGF placental growth factor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G5 phospholipase A2, group V
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLCZ1 phospholipase C, zeta 1
PLK1 polo-like kinase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARA peroxisome proliferator-activated receptor alpha
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PRKX protein kinase, X-linked
PRL prolactin
PRNP prion protein
PRTN3 proteinase 3
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2B protein tyrosine kinase 2 beta
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTTG1 pituitary tumor-transforming 1
PVR poliovirus receptor
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
PYCARD PYD and CARD domain containing
RAB8A RAB8A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RALBP1 ralA binding protein 1
RARG retinoic acid receptor, gamma
RDX radixin
RHBDL2 rhomboid, veinlet-like 2 (Drosophila)
RHOA ras homolog family member A
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RYR2 ryanodine receptor 2 (cardiac)
S100A6 S100 calcium binding protein A6
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S1PR3 sphingosine-1-phosphate receptor 3
SAMHD1 SAM domain and HD domain 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLAMF6 SLAM family member 6
SLAMF7 SLAM family member 7
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SNAI2 snail family zinc finger 2
SORBS3 sorbin and SH3 domain containing 3
SP1 Sp1 transcription factor
SPN sialophorin
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF2 sterol regulatory element binding transcription factor 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK38L serine/threonine kinase 38 like
STK4 serine/threonine kinase 4
SYK spleen tyrosine kinase
THBS1 thrombospondin 1
TICAM1 toll-like receptor adaptor molecule 1
TLK1 tousled-like kinase 1
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF18 tumor necrosis factor receptor superfamily, member 18
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TP53 tumor protein p53
TPI1 triosephosphate isomerase 1
TRA T cell receptor alpha locus
TREM1 triggering receptor expressed on myeloid cells 1
TRIM21 tripartite motif containing 21
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSHR thyroid stimulating hormone receptor
TTBK2 tau tubulin kinase 2
TXN thioredoxin
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
VWF von Willebrand factor
WNT3 wingless-type MMTV integration site family, member 3
WNT5A wingless-type MMTV integration site family, member 5A
XPO1 exportin 1
YY1 YY1 transcription factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZEB1 zinc finger E-box binding homeobox 1