trimethadione-2486 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the trimethadione-2486 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK4 aarF domain containing kinase 4
ADCY9 adenylate cyclase 9
ADRA2C adrenoceptor alpha 2C
ADRB3 adrenoceptor beta 3
AMH anti-Mullerian hormone
ANGPTL2 angiopoietin-like 2
ASMT acetylserotonin O-methyltransferase
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
BIN1 bridging integrator 1
BLZF1 basic leucine zipper nuclear factor 1
BMP2 bone morphogenetic protein 2
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C21ORF2 chromosome 21 open reading frame 2
C2ORF27A chromosome 2 open reading frame 27A
CACFD1 calcium channel flower domain containing 1
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAMK1D calcium/calmodulin-dependent protein kinase ID
CASC1 cancer susceptibility candidate 1
CDK14 cyclin-dependent kinase 14
CDRT1 CMT1A duplicated region transcript 1
CEP41 centrosomal protein 41kDa
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CLCN1 chloride channel, voltage-sensitive 1
CNOT2 CCR4-NOT transcription complex, subunit 2
CNPY4 canopy FGF signaling regulator 4
COL6A1 collagen, type VI, alpha 1
COL9A3 collagen, type IX, alpha 3
CRAT carnitine O-acetyltransferase
CSPG4 chondroitin sulfate proteoglycan 4
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DCTN2 dynactin 2 (p50)
DMC1 DNA meiotic recombinase 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FOLR2 folate receptor 2 (fetal)
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GLB1L galactosidase, beta 1-like
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GOLGA2P5 golgin A2 pseudogene 5
GP5 glycoprotein V (platelet)
GPM6A glycoprotein M6A
HAP1 huntingtin-associated protein 1
HOXA4 homeobox A4
IGLV1-44 immunoglobulin lambda variable 1-44
INTS3 integrator complex subunit 3
IRF4 interferon regulatory factor 4
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIFC3 kinesin family member C3
KRT9 keratin 9, type I
LAD1 ladinin 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LPAR3 lysophosphatidic acid receptor 3
LRRC31 leucine rich repeat containing 31
LRRC41 leucine rich repeat containing 41
MAGEA5 melanoma antigen family A5
MAP4 microtubule-associated protein 4
MBNL3 muscleblind-like splicing regulator 3
MPDZ multiple PDZ domain protein
MTAP methylthioadenosine phosphorylase
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NR2C1 nuclear receptor subfamily 2, group C, member 1
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
NUP88 nucleoporin 88kDa
PARP12 poly (ADP-ribose) polymerase family, member 12
PCDH17 protocadherin 17
PEG10 paternally expressed 10
PIGR polymeric immunoglobulin receptor
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PODNL1 podocan-like 1
PRSS8 protease, serine, 8
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RAB11B RAB11B, member RAS oncogene family
RASAL1 RAS protein activator like 1 (GAP1 like)
RELN reelin
RIMS1 regulating synaptic membrane exocytosis 1
RPL7 ribosomal protein L7
RYR1 ryanodine receptor 1 (skeletal)
SFN stratifin
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPATA6 spermatogenesis associated 6
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRRM2 serine/arginine repetitive matrix 2
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STMN4 stathmin-like 4
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
SYT12 synaptotagmin XII
TCP11L1 t-complex 11, testis-specific-like 1
TEAD3 TEA domain family member 3
TGFB1I1 transforming growth factor beta 1 induced transcript 1
THTPA thiamine triphosphatase
TMSB4Y thymosin beta 4, Y-linked
TTC12 tetratricopeptide repeat domain 12
WNT16 wingless-type MMTV integration site family, member 16
ZER1 zyg-11 related, cell cycle regulator
ZMIZ2 zinc finger, MIZ-type containing 2

decreased expression

Symbol Name
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ALPK1 alpha-kinase 1
ALS2CL ALS2 C-terminal like
AMDHD2 amidohydrolase domain containing 2
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ART1 ADP-ribosyltransferase 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTBD18 BTB (POZ) domain containing 18
C17ORF53 chromosome 17 open reading frame 53
C17ORF80 chromosome 17 open reading frame 80
CAPN5 calpain 5
CDCP1 CUB domain containing protein 1
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CORT cortistatin
DCAF17 DDB1 and CUL4 associated factor 17
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPEP2 dipeptidase 2
DZANK1 double zinc ribbon and ankyrin repeat domains 1
FBP1 fructose-1,6-bisphosphatase 1
FGGY FGGY carbohydrate kinase domain containing
FOXN2 forkhead box N2
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GAREM GRB2 associated, regulator of MAPK1
GATA6 GATA binding protein 6
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GSDMD gasdermin D
GSTCD glutathione S-transferase, C-terminal domain containing
HAMP hepcidin antimicrobial peptide
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HINFP histone H4 transcription factor
HIST1H1E histone cluster 1, H1e
HIST1H3B histone cluster 1, H3b
HIST1H4E histone cluster 1, H4e
HP haptoglobin
ICAM5 intercellular adhesion molecule 5, telencephalin
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IQSEC2 IQ motif and Sec7 domain 2
LIN7B lin-7 homolog B (C. elegans)
LMTK1 lemur tail kinase 1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRP2 low density lipoprotein receptor-related protein 2
MAK male germ cell-associated kinase
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MMP9 matrix metallopeptidase 9
MRAS muscle RAS oncogene homolog
MREG melanoregulin
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NCS1 neuronal calcium sensor 1
NECAB2 N-terminal EF-hand calcium binding protein 2
NLK nemo-like kinase
OVGP1 oviductal glycoprotein 1, 120kDa
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAQR4 progestin and adipoQ receptor family member IV
PDLIM2 PDZ and LIM domain 2 (mystique)
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PEX26 peroxisomal biogenesis factor 26
PHACTR1 phosphatase and actin regulator 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PITX2 paired-like homeodomain 2
PLCD1 phospholipase C, delta 1
PMFBP1 polyamine modulated factor 1 binding protein 1
PQLC2 PQ loop repeat containing 2
PSKH1 protein serine kinase H1
PYGB phosphorylase, glycogen; brain
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SETD1A SET domain containing 1A
SHPK sedoheptulokinase
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOX12 SRY (sex determining region Y)-box 12
TAOK1 TAO kinase 1
TDP1 tyrosyl-DNA phosphodiesterase 1
THBS4 thrombospondin 4
TICAM1 toll-like receptor adaptor molecule 1
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRABD TraB domain containing
TRIM45 tripartite motif containing 45
TRPS1 trichorhinophalangeal syndrome I
TSPYL2 TSPY-like 2
UCN urocortin
USP19 ubiquitin specific peptidase 19
USP6NL USP6 N-terminal like
VEGFB vascular endothelial growth factor B
VNN2 vanin 2
XAB2 XPA binding protein 2
ZBTB22 zinc finger and BTB domain containing 22
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF37BP zinc finger protein 37B, pseudogene
ZNF428 zinc finger protein 428