trimethadione-2846 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the trimethadione-2846 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP11 A kinase (PRKA) anchor protein 11
ANP32A-IT1 ANP32A intronic transcript 1
APOC1 apolipoprotein C-I
ATM ATM serine/threonine kinase
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
C4ORF29 chromosome 4 open reading frame 29
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC9 coiled-coil domain containing 9
CD82 CD82 molecule
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CFLAR CASP8 and FADD-like apoptosis regulator
CHM choroideremia (Rab escort protein 1)
CIDEB cell death-inducing DFFA-like effector b
CLEC11A C-type lectin domain family 11, member A
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CTBP2 C-terminal binding protein 2
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
DIO2 deiodinase, iodothyronine, type II
DMWD dystrophia myotonica, WD repeat containing
DSC2 desmocollin 2
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EIF1 eukaryotic translation initiation factor 1
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
EML2 echinoderm microtubule associated protein like 2
ERN2 endoplasmic reticulum to nucleus signaling 2
EXOG endo/exonuclease (5'-3'), endonuclease G-like
FAM186A family with sequence similarity 186, member A
FAM63B family with sequence similarity 63, member B
FST follistatin
FUT2 fucosyltransferase 2 (secretor status included)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GADD45G growth arrest and DNA-damage-inducible, gamma
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLB1L galactosidase, beta 1-like
GLRA3 glycine receptor, alpha 3
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GPC1 glypican 1
GPR143 G protein-coupled receptor 143
GUSBP3 glucuronidase, beta pseudogene 3
H2AFX H2A histone family, member X
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HFE hemochromatosis
HHLA1 HERV-H LTR-associating 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICA1 islet cell autoantigen 1, 69kDa
ICAM1 intercellular adhesion molecule 1
IL6ST interleukin 6 signal transducer
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
KHSRP KH-type splicing regulatory protein
KLF9 Kruppel-like factor 9
KLHL20 kelch-like family member 20
KLHL24 kelch-like family member 24
LAMP1 lysosomal-associated membrane protein 1
LIME1 Lck interacting transmembrane adaptor 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LZTR1 leucine-zipper-like transcription regulator 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MED16 mediator complex subunit 16
MED18 mediator complex subunit 18
MEX3D mex-3 RNA binding family member D
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MTCP1 mature T-cell proliferation 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLIN2 perilipin 2
POU2F2 POU class 2 homeobox 2
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPP1R10 protein phosphatase 1, regulatory subunit 10
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
REPS1 RALBP1 associated Eps domain containing 1
RNFT1 ring finger protein, transmembrane 1
SCAI suppressor of cancer cell invasion
SCAMP1 secretory carrier membrane protein 1
SFXN3 sideroflexin 3
SH3BP2 SH3-domain binding protein 2
SIDT2 SID1 transmembrane family, member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNTA1 syntrophin, alpha 1
STK16 serine/threonine kinase 16
STK4 serine/threonine kinase 4
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SZRD1 SUZ RNA binding domain containing 1
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRD T cell receptor delta locus
TRIO trio Rho guanine nucleotide exchange factor
TTC9 tetratricopeptide repeat domain 9
TUBA3C tubulin, alpha 3c
UBQLN4 ubiquilin 4
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
WDR76 WD repeat domain 76
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBTB17 zinc finger and BTB domain containing 17
ZBTB33 zinc finger and BTB domain containing 33
ZMYND8 zinc finger, MYND-type containing 8
ZNF324 zinc finger protein 324
ZNF652 zinc finger protein 652
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACYP2 acylphosphatase 2, muscle type
ANXA2P3 annexin A2 pseudogene 3
ARC activity-regulated cytoskeleton-associated protein
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BTBD2 BTB (POZ) domain containing 2
C5 complement component 5
C5ORF45 chromosome 5 open reading frame 45
CA11 carbonic anhydrase XI
CA5BP1 carbonic anhydrase VB pseudogene 1
CBX4 chromobox homolog 4
CCDC85C coiled-coil domain containing 85C
CENPT centromere protein T
CEP170B centrosomal protein 170B
CNGB3 cyclic nucleotide gated channel beta 3
CORT cortistatin
CPPED1 calcineurin-like phosphoesterase domain containing 1
DEAF1 DEAF1 transcription factor
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ETAA1 Ewing tumor-associated antigen 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM184A family with sequence similarity 184, member A
FAM198B family with sequence similarity 198, member B
FAM204A family with sequence similarity 204, member A
FBXL2 F-box and leucine-rich repeat protein 2
FBXO22 F-box protein 22
FILIP1L filamin A interacting protein 1-like
FOSL1 FOS-like antigen 1
FOXI1 forkhead box I1
GAMT guanidinoacetate N-methyltransferase
GAREM GRB2 associated, regulator of MAPK1
HIST1H2BO histone cluster 1, H2bo
HIST1H4D histone cluster 1, H4d
HOXA4 homeobox A4
HOXC11 homeobox C11
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IL4R interleukin 4 receptor
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITPKB inositol-trisphosphate 3-kinase B
KLC2 kinesin light chain 2
KLHL26 kelch-like family member 26
KLK5 kallikrein-related peptidase 5
LINC00115 long intergenic non-protein coding RNA 115
LRP5L low density lipoprotein receptor-related protein 5-like
LRRC61 leucine rich repeat containing 61
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP9 microtubule-associated protein 9
METTL16 methyltransferase like 16
MTCL1 microtubule crosslinking factor 1
MYO19 myosin XIX
NPTX1 neuronal pentraxin I
ORAI3 ORAI calcium release-activated calcium modulator 3
OTUD3 OTU deubiquitinase 3
PAIP2B poly(A) binding protein interacting protein 2B
PHEX phosphate regulating endopeptidase homolog, X-linked
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
POLH polymerase (DNA directed), eta
PRPH peripherin
PSKH1 protein serine kinase H1
PTK6 protein tyrosine kinase 6
RAD54L2 RAD54-like 2 (S. cerevisiae)
RFXAP regulatory factor X-associated protein
RIN2 Ras and Rab interactor 2
RNF126P1 ring finger protein 126 pseudogene 1
SALL2 spalt-like transcription factor 2
SCD5 stearoyl-CoA desaturase 5
SCML2 sex comb on midleg-like 2 (Drosophila)
SCN1B sodium channel, voltage gated, type I beta subunit
SIX1 SIX homeobox 1
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SPAG4 sperm associated antigen 4
SPON2 spondin 2, extracellular matrix protein
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TFF2 trefoil factor 2
THRAP3 thyroid hormone receptor associated protein 3
TMC7 transmembrane channel-like 7
TMEM209 transmembrane protein 209
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBXN6 UBX domain protein 6
XK X-linked Kx blood group
YBX2 Y box binding protein 2
ZDHHC14 zinc finger, DHHC-type containing 14
ZFP69B ZFP69 zinc finger protein B
ZNF141 zinc finger protein 141
ZNF227 zinc finger protein 227
ZNF254 zinc finger protein 254
ZNF34 zinc finger protein 34
ZNF365 zinc finger protein 365