trimethobenzamide-1502 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the trimethobenzamide-1502 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ARHGAP44 Rho GTPase activating protein 44
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BMPR1A bone morphogenetic protein receptor, type IA
BRAP BRCA1 associated protein
BTF3P11 basic transcription factor 3 pseudogene 11
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CA12 carbonic anhydrase XII
CCPG1 cell cycle progression 1
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDC14A cell division cycle 14A
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CES3 carboxylesterase 3
COL1A1 collagen, type I, alpha 1
CRISP2 cysteine-rich secretory protein 2
CRTC1 CREB regulated transcription coactivator 1
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CUL7 cullin 7
DCAKD dephospho-CoA kinase domain containing
DIEXF digestive organ expansion factor homolog (zebrafish)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DNAL4 dynein, axonemal, light chain 4
DTNA dystrobrevin, alpha
EFCAB2 EF-hand calcium binding domain 2
ELL elongation factor RNA polymerase II
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ESR1 estrogen receptor 1
FAM149B1 family with sequence similarity 149, member B1
FAM184A family with sequence similarity 184, member A
FBLN1 fibulin 1
FBXO2 F-box protein 2
FLT4 fms-related tyrosine kinase 4
FRMD8 FERM domain containing 8
FST follistatin
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GOSR2 golgi SNAP receptor complex member 2
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HFE hemochromatosis
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HSF2BP heat shock transcription factor 2 binding protein
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
ITFG2 integrin alpha FG-GAP repeat containing 2
LMAN1 lectin, mannose-binding, 1
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MARC2 mitochondrial amidoxime reducing component 2
MAST2 microtubule associated serine/threonine kinase 2
MBD1 methyl-CpG binding domain protein 1
MFSD7 major facilitator superfamily domain containing 7
MLN motilin
MRC2 mannose receptor, C type 2
MTA2 metastasis associated 1 family, member 2
MTMR2 myotubularin related protein 2
MUC3A mucin 3A, cell surface associated
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NDRG2 NDRG family member 2
NEB nebulin
NGLY1 N-glycanase 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
NUP62CL nucleoporin 62kDa C-terminal like
PAPOLG poly(A) polymerase gamma
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLK3 polo-like kinase 3
POFUT1 protein O-fucosyltransferase 1
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKCH protein kinase C, eta
PSKH1 protein serine kinase H1
RECQL5 RecQ protein-like 5
RHOH ras homolog family member H
RIN3 Ras and Rab interactor 3
RNF122 ring finger protein 122
RNF219 ring finger protein 219
RNFT2 ring finger protein, transmembrane 2
RPS14 ribosomal protein S14
RRAGD Ras-related GTP binding D
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
RRP1 ribosomal RNA processing 1
SLC17A2 solute carrier family 17, member 2
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1
SNCG synuclein, gamma (breast cancer-specific protein 1)
SPRY2 sprouty homolog 2 (Drosophila)
TM2D1 TM2 domain containing 1
TMEM242 transmembrane protein 242
TMEM259 transmembrane protein 259
TRAK1 trafficking protein, kinesin binding 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
ZFYVE26 zinc finger, FYVE domain containing 26
ZNF250 zinc finger protein 250
ZNF446 zinc finger protein 446
ZNF767P zinc finger family member 767, pseudogene
ZNF771 zinc finger protein 771
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
APOD apolipoprotein D
ARHGAP4 Rho GTPase activating protein 4
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
C19ORF73 chromosome 19 open reading frame 73
C1ORF105 chromosome 1 open reading frame 105
C21ORF91 chromosome 21 open reading frame 91
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CORT cortistatin
CRY2 cryptochrome circadian clock 2
CSF1R colony stimulating factor 1 receptor
CST6 cystatin E/M
CSTA cystatin A (stefin A)
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOC2A double C2-like domains, alpha
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EYA2 EYA transcriptional coactivator and phosphatase 2
FADS2 fatty acid desaturase 2
FBXO31 F-box protein 31
FGL1 fibrinogen-like 1
FOXN2 forkhead box N2
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FSTL3 follistatin-like 3 (secreted glycoprotein)
FZD4 frizzled class receptor 4
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GSTA4 glutathione S-transferase alpha 4
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2AJ histone cluster 1, H2aj
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFI35 interferon-induced protein 35
IL22 interleukin 22
ITPKB inositol-trisphosphate 3-kinase B
JMJD4 jumonji domain containing 4
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNK15 potassium channel, two pore domain subfamily K, member 15
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LRP3 low density lipoprotein receptor-related protein 3
LZTR1 leucine-zipper-like transcription regulator 1
MOGS mannosyl-oligosaccharide glucosidase
MTHFSD methenyltetrahydrofolate synthetase domain containing
MYL5 myosin, light chain 5, regulatory
MYO1D myosin ID
NKX3-2 NK3 homeobox 2
NLRX1 NLR family member X1
PACS1 phosphofurin acidic cluster sorting protein 1
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PHEX phosphate regulating endopeptidase homolog, X-linked
PITX2 paired-like homeodomain 2
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PMEL premelanosome protein
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRKCE protein kinase C, epsilon
PRMT7 protein arginine methyltransferase 7
PROCR protein C receptor, endothelial
PRSS16 protease, serine, 16 (thymus)
PTPRU protein tyrosine phosphatase, receptor type, U
RAD54L2 RAD54-like 2 (S. cerevisiae)
RHOF ras homolog family member F (in filopodia)
RNF25 ring finger protein 25
RNF39 ring finger protein 39
RNF43 ring finger protein 43
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIDT1 SID1 transmembrane family, member 1
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SNAI2 snail family zinc finger 2
SND1-IT1 SND1 intronic transcript 1
SPRYD7 SPRY domain containing 7
STIM1 stromal interaction molecule 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TCTN1 tectonic family member 1
TESC tescalcin
TLN1 talin 1
TMEM104 transmembrane protein 104
TMEM159 transmembrane protein 159
TTLL1 tubulin tyrosine ligase-like family member 1
UBQLN4 ubiquilin 4
VGF VGF nerve growth factor inducible
VPS9D1 VPS9 domain containing 1
VWA1 von Willebrand factor A domain containing 1
WDR62 WD repeat domain 62
ZFHX3 zinc finger homeobox 3
ZNF205 zinc finger protein 205
ZNF442 zinc finger protein 442