trimethobenzamide-1920 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the trimethobenzamide-1920 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOX2 acyl-CoA oxidase 2, branched chain
ACTC1 actin, alpha, cardiac muscle 1
APOM apolipoprotein M
ATG4B autophagy related 4B, cysteine peptidase
AXIN1 axin 1
BCL2L14 BCL2-like 14 (apoptosis facilitator)
C14ORF79 chromosome 14 open reading frame 79
C1ORF116 chromosome 1 open reading frame 116
CDC73 cell division cycle 73
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CENPI centromere protein I
CIZ1 CDKN1A interacting zinc finger protein 1
CLIC4 chloride intracellular channel 4
CPNE7 copine VII
CST8 cystatin 8 (cystatin-related epididymal specific)
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DTNA dystrobrevin, alpha
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EPRS glutamyl-prolyl-tRNA synthetase
ERN1 endoplasmic reticulum to nucleus signaling 1
FAM65A family with sequence similarity 65, member A
FGFR1 fibroblast growth factor receptor 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GLS glutaminase
GRB10 growth factor receptor-bound protein 10
GRK6 G protein-coupled receptor kinase 6
HFE hemochromatosis
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HIST1H3G histone cluster 1, H3g
IRS2 insulin receptor substrate 2
ITSN1 intersectin 1 (SH3 domain protein)
KIAA1109 KIAA1109
KIF2A kinesin heavy chain member 2A
KMT2A lysine (K)-specific methyltransferase 2A
KRT4 keratin 4, type II
LUZP1 leucine zipper protein 1
LY6G6C lymphocyte antigen 6 complex, locus G6C
MCF2L MCF.2 cell line derived transforming sequence-like
MECP2 methyl CpG binding protein 2
MED20 mediator complex subunit 20
MOCS3 molybdenum cofactor synthesis 3
MPDZ multiple PDZ domain protein
MRPL57 mitochondrial ribosomal protein L57
MXD4 MAX dimerization protein 4
MYL9 myosin, light chain 9, regulatory
NCOA2 nuclear receptor coactivator 2
NIPAL3 NIPA-like domain containing 3
NSUN5P1 NOP2/Sun domain family, member 5 pseudogene 1
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
OASL 2'-5'-oligoadenylate synthetase-like
OLFM1 olfactomedin 1
PABPN1 poly(A) binding protein, nuclear 1
PC pyruvate carboxylase
PCBP2 poly(rC) binding protein 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKCQ protein kinase C, theta
PRPF39 pre-mRNA processing factor 39
PRPH peripherin
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PTDSS2 phosphatidylserine synthase 2
PTGES prostaglandin E synthase
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RAD50 RAD50 homolog (S. cerevisiae)
RANBP10 RAN binding protein 10
RARB retinoic acid receptor, beta
REEP1 receptor accessory protein 1
RNF167 ring finger protein 167
RPS3A ribosomal protein S3A
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SAMHD1 SAM domain and HD domain 1
SEZ6L seizure related 6 homolog (mouse)-like
SH2D3A SH2 domain containing 3A
SIN3B SIN3 transcription regulator family member B
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TCN2 transcobalamin II
TMEM206 transmembrane protein 206
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TPCN1 two pore segment channel 1
TRAF4 TNF receptor-associated factor 4
TRIM29 tripartite motif containing 29
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TTC3 tetratricopeptide repeat domain 3
TTLL4 tubulin tyrosine ligase-like family member 4
UBE2G2 ubiquitin-conjugating enzyme E2G 2
ZMAT3 zinc finger, matrin-type 3
ZNF280A zinc finger protein 280A
ZNF688 zinc finger protein 688

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACTG2 actin, gamma 2, smooth muscle, enteric
ARGLU1 arginine and glutamate rich 1
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
AUNIP aurora kinase A and ninein interacting protein
C1ORF109 chromosome 1 open reading frame 109
C1ORF174 chromosome 1 open reading frame 174
CALCOCO1 calcium binding and coiled-coil domain 1
CCDC130 coiled-coil domain containing 130
CCDC47 coiled-coil domain containing 47
CCNO cyclin O
CHPT1 choline phosphotransferase 1
CLK1 CDC-like kinase 1
CNR2 cannabinoid receptor 2 (macrophage)
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CPOX coproporphyrinogen oxidase
CROT carnitine O-octanoyltransferase
CS citrate synthase
CTSD cathepsin D
CTSF cathepsin F
DHRS1 dehydrogenase/reductase (SDR family) member 1
DIXDC1 DIX domain containing 1
DPH2 DPH2 homolog (S. cerevisiae)
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDAR ectodysplasin A receptor
EMC9 ER membrane protein complex subunit 9
EXOC3 exocyst complex component 3
FAIM Fas apoptotic inhibitory molecule
FAM188A family with sequence similarity 188, member A
FAM57A family with sequence similarity 57, member A
FCGRT Fc fragment of IgG, receptor, transporter, alpha
GBAP1 glucosidase, beta, acid pseudogene 1
GOLGA8B golgin A8 family, member B
GPR27 G protein-coupled receptor 27
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GTPBP6 GTP binding protein 6 (putative)
H2AFY2 H2A histone family, member Y2
IP6K1 inositol hexakisphosphate kinase 1
IRF7 interferon regulatory factor 7
JMJD4 jumonji domain containing 4
KAT2B K(lysine) acetyltransferase 2B
KCTD15 potassium channel tetramerization domain containing 15
KCTD3 potassium channel tetramerization domain containing 3
KIFC1 kinesin family member C1
KRT34 keratin 34, type I
LRP5 low density lipoprotein receptor-related protein 5
LZTFL1 leucine zipper transcription factor-like 1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MEIS3P1 Meis homeobox 3 pseudogene 1
MEPCE methylphosphate capping enzyme
MFSD5 major facilitator superfamily domain containing 5
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
NOD1 nucleotide-binding oligomerization domain containing 1
NRBP1 nuclear receptor binding protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NSUN3 NOP2/Sun domain family, member 3
NVL nuclear VCP-like
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OSBPL11 oxysterol binding protein-like 11
OSTM1 osteopetrosis associated transmembrane protein 1
PADI1 peptidyl arginine deiminase, type I
PAK1IP1 PAK1 interacting protein 1
PARP16 poly (ADP-ribose) polymerase family, member 16
PCDHGB5 protocadherin gamma subfamily B, 5
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PLEKHO2 pleckstrin homology domain containing, family O member 2
PODXL podocalyxin-like
PPT2 palmitoyl-protein thioesterase 2
PRPF38B pre-mRNA processing factor 38B
PYGB phosphorylase, glycogen; brain
R3HDM2 R3H domain containing 2
RAD54L RAD54-like (S. cerevisiae)
RCOR3 REST corepressor 3
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RP2 retinitis pigmentosa 2 (X-linked recessive)
SALL2 spalt-like transcription factor 2
SDF2L1 stromal cell-derived factor 2-like 1
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC35E3 solute carrier family 35, member E3
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SNX15 sorting nexin 15
TAC3 tachykinin 3
TASP1 taspase, threonine aspartase, 1
TMA7 translation machinery associated 7 homolog (S. cerevisiae)
TMEM104 transmembrane protein 104
TRIM21 tripartite motif containing 21
UBXN2B UBX domain protein 2B
USP32 ubiquitin specific peptidase 32
WNT16 wingless-type MMTV integration site family, member 16
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
ZC4H2 zinc finger, C4H2 domain containing
ZHX2 zinc fingers and homeoboxes 2
ZIM2 zinc finger, imprinted 2
ZNF226 zinc finger protein 226
ZNF394 zinc finger protein 394
ZNF669 zinc finger protein 669