trimethobenzamide-2002 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the trimethobenzamide-2002 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ACAA2 acetyl-CoA acyltransferase 2
ACTN2 actinin, alpha 2
ADK adenosine kinase
AHNAK AHNAK nucleoprotein
ANKRD12 ankyrin repeat domain 12
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ATP11B ATPase, class VI, type 11B
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATP9B ATPase, class II, type 9B
AZI2 5-azacytidine induced 2
BBX bobby sox homolog (Drosophila)
BCLAF1 BCL2-associated transcription factor 1
BSDC1 BSD domain containing 1
CAPG capping protein (actin filament), gelsolin-like
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC25 coiled-coil domain containing 25
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CRCP CGRP receptor component
DGCR8 DGCR8 microprocessor complex subunit
DTWD1 DTW domain containing 1
EIF1 eukaryotic translation initiation factor 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EPHB6 EPH receptor B6
EPM2AIP1 EPM2A (laforin) interacting protein 1
FAM3C family with sequence similarity 3, member C
FBXO5 F-box protein 5
FNBP1 formin binding protein 1
FNTB farnesyltransferase, CAAX box, beta
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GNS glucosamine (N-acetyl)-6-sulfatase
GRIK5 glutamate receptor, ionotropic, kainate 5
GRK5 G protein-coupled receptor kinase 5
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IRF2 interferon regulatory factor 2
ITM2B integral membrane protein 2B
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
LENEP lens epithelial protein
LIN7C lin-7 homolog C (C. elegans)
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAST2 microtubule associated serine/threonine kinase 2
MGAM maltase-glucoamylase
MNS1 meiosis-specific nuclear structural 1
MR1 major histocompatibility complex, class I-related
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MTMR12 myotubularin related protein 12
MYL10 myosin, light chain 10, regulatory
NADK NAD kinase
NHLRC2 NHL repeat containing 2
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOP16 NOP16 nucleolar protein
NRP2 neuropilin 2
NXPH3 neurexophilin 3
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
PAPPA2 pappalysin 2
PARVA parvin, alpha
PAX1 paired box 1
PDCL phosducin-like
PGRMC2 progesterone receptor membrane component 2
PIGV phosphatidylinositol glycan anchor biosynthesis, class V
PLAGL1 pleiomorphic adenoma gene-like 1
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PTGDS prostaglandin D2 synthase 21kDa (brain)
RABGAP1L RAB GTPase activating protein 1-like
RARA retinoic acid receptor, alpha
RB1CC1 RB1-inducible coiled-coil 1
RBMS1 RNA binding motif, single stranded interacting protein 1
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RNF170 ring finger protein 170
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS11 ribosomal protein S11
SIGLEC15 sialic acid binding Ig-like lectin 15
SIRPA signal-regulatory protein alpha
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMC5 structural maintenance of chromosomes 5
SND1-IT1 SND1 intronic transcript 1
SOD2 superoxide dismutase 2, mitochondrial
SON SON DNA binding protein
SYNGR1 synaptogyrin 1
TFG TRK-fused gene
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TPRA1 transmembrane protein, adipocyte asscociated 1
TTC37 tetratricopeptide repeat domain 37
UBQLN4 ubiquilin 4
UBR5 ubiquitin protein ligase E3 component n-recognin 5
USF2 upstream transcription factor 2, c-fos interacting
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
YIPF4 Yip1 domain family, member 4
ZC3H13 zinc finger CCCH-type containing 13
ZC3H7B zinc finger CCCH-type containing 7B
ZFAND1 zinc finger, AN1-type domain 1
ZMYM2 zinc finger, MYM-type 2
ZNF43 zinc finger protein 43

decreased expression

Symbol Name
AATF apoptosis antagonizing transcription factor
ACOT9 acyl-CoA thioesterase 9
ADRB2 adrenoceptor beta 2, surface
ANAPC2 anaphase promoting complex subunit 2
APH1A APH1A gamma secretase subunit
APOC2 apolipoprotein C-II
ASB13 ankyrin repeat and SOCS box containing 13
ASCC2 activating signal cointegrator 1 complex subunit 2
ATXN2 ataxin 2
AURKAIP1 aurora kinase A interacting protein 1
BATF basic leucine zipper transcription factor, ATF-like
BPI bactericidal/permeability-increasing protein
C1ORF54 chromosome 1 open reading frame 54
C2CD2 C2 calcium-dependent domain containing 2
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CCDC86 coiled-coil domain containing 86
CD151 CD151 molecule (Raph blood group)
CEP85 centrosomal protein 85kDa
CHMP1A charged multivesicular body protein 1A
CLDN15 claudin 15
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CMTR1 cap methyltransferase 1
CNR2 cannabinoid receptor 2 (macrophage)
CPNE1 copine I
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DOK3 docking protein 3
DUSP5 dual specificity phosphatase 5
EGLN2 egl-9 family hypoxia-inducible factor 2
ERF Ets2 repressor factor
FBXO46 F-box protein 46
FIBP fibroblast growth factor (acidic) intracellular binding protein
FOSL1 FOS-like antigen 1
FPGS folylpolyglutamate synthase
GALNS galactosamine (N-acetyl)-6-sulfatase
GLB1L2 galactosidase, beta 1-like 2
GMCL1 germ cell-less, spermatogenesis associated 1
GMEB1 glucocorticoid modulatory element binding protein 1
GP1BA glycoprotein Ib (platelet), alpha polypeptide
HRAS Harvey rat sarcoma viral oncogene homolog
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
INTS12 integrator complex subunit 12
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRF9 interferon regulatory factor 9
JMJD4 jumonji domain containing 4
KCTD15 potassium channel tetramerization domain containing 15
KIZ kizuna centrosomal protein
LGALS9 lectin, galactoside-binding, soluble, 9
LIMA1 LIM domain and actin binding 1
LRRK1 leucine-rich repeat kinase 1
MACROD1 MACRO domain containing 1
MAN1C1 mannosidase, alpha, class 1C, member 1
MATK megakaryocyte-associated tyrosine kinase
MECR mitochondrial trans-2-enoyl-CoA reductase
MED24 mediator complex subunit 24
MFSD12 major facilitator superfamily domain containing 12
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MXRA8 matrix-remodelling associated 8
NABP2 nucleic acid binding protein 2
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NPPA natriuretic peptide A
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NUPL2 nucleoporin like 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PGAM1 phosphoglycerate mutase 1 (brain)
PIH1D1 PIH1 domain containing 1
PISD phosphatidylserine decarboxylase
PLEKHO1 pleckstrin homology domain containing, family O member 1
POLE polymerase (DNA directed), epsilon, catalytic subunit
PPP6R3 protein phosphatase 6, regulatory subunit 3
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RARS arginyl-tRNA synthetase
RIC8A RIC8 guanine nucleotide exchange factor A
RNF115 ring finger protein 115
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SMYD5 SMYD family member 5
SRP19 signal recognition particle 19kDa
SSNA1 Sjogren syndrome nuclear autoantigen 1
STAC SH3 and cysteine rich domain
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D31 TBC1 domain family, member 31
TERT telomerase reverse transcriptase
TMEM184B transmembrane protein 184B
TRAC T cell receptor alpha constant
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
UBA5 ubiquitin-like modifier activating enzyme 5
UBE2O ubiquitin-conjugating enzyme E2O
UNC13B unc-13 homolog B (C. elegans)
WDR45 WD repeat domain 45
XPA xeroderma pigmentosum, complementation group A
ZBED1 zinc finger, BED-type containing 1
ZC3H12A zinc finger CCCH-type containing 12A
ZDHHC7 zinc finger, DHHC-type containing 7
ZFP36 ZFP36 ring finger protein