trimethobenzamide-4180 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the trimethobenzamide-4180 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABI2 abl-interactor 2
ACAA2 acetyl-CoA acyltransferase 2
ADAM22 ADAM metallopeptidase domain 22
ADAM8 ADAM metallopeptidase domain 8
ADCY10 adenylate cyclase 10 (soluble)
ADGRE3 adhesion G protein-coupled receptor E3
AK1 adenylate kinase 1
AKAP7 A kinase (PRKA) anchor protein 7
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BAIAP3 BAI1-associated protein 3
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C10ORF12 chromosome 10 open reading frame 12
C14ORF1 chromosome 14 open reading frame 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCDC134 coiled-coil domain containing 134
CCKAR cholecystokinin A receptor
CD160 CD160 molecule
CD248 CD248 molecule, endosialin
CEP112 centrosomal protein 112kDa
CEP295 centrosomal protein 295kDa
CFDP1 craniofacial development protein 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNPY4 canopy FGF signaling regulator 4
COL6A3 collagen, type VI, alpha 3
CTRC chymotrypsin C (caldecrin)
CTSZ cathepsin Z
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
DGAT1 diacylglycerol O-acyltransferase 1
DLX2 distal-less homeobox 2
DMP1 dentin matrix acidic phosphoprotein 1
DMPK dystrophia myotonica-protein kinase
DOK4 docking protein 4
DPF1 D4, zinc and double PHD fingers family 1
FAAH fatty acid amide hydrolase
FHL1 four and a half LIM domains 1
FLOT1 flotillin 1
GALR3 galanin receptor 3
GM2A GM2 ganglioside activator
GPC3 glypican 3
GRK5 G protein-coupled receptor kinase 5
GRM7 glutamate receptor, metabotropic 7
GSK3A glycogen synthase kinase 3 alpha
GULP1 GULP, engulfment adaptor PTB domain containing 1
HEPH hephaestin
HIST1H4A histone cluster 1, H4a
HP1BP3 heterochromatin protein 1, binding protein 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IQCA1 IQ motif containing with AAA domain 1
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLF6 Kruppel-like factor 6
KLRC4 killer cell lectin-like receptor subfamily C, member 4
KMT2A lysine (K)-specific methyltransferase 2A
KRT17 keratin 17, type I
KRT23 keratin 23, type I
LAT2 linker for activation of T cells family, member 2
LMX1B LIM homeobox transcription factor 1, beta
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MED16 mediator complex subunit 16
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MR1 major histocompatibility complex, class I-related
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NCKIPSD NCK interacting protein with SH3 domain
NIPAL3 NIPA-like domain containing 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OMD osteomodulin
OR1G1 olfactory receptor, family 1, subfamily G, member 1
PID1 phosphotyrosine interaction domain containing 1
POFUT1 protein O-fucosyltransferase 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRB1 proline-rich protein BstNI subfamily 1
PRKG2 protein kinase, cGMP-dependent, type II
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB3A RAB3A, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RB1 retinoblastoma 1
RRBP1 ribosome binding protein 1
RUNDC3A RUN domain containing 3A
SAYSD1 SAYSVFN motif domain containing 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SOX21 SRY (sex determining region Y)-box 21
SP4 Sp4 transcription factor
STAT4 signal transducer and activator of transcription 4
STS steroid sulfatase (microsomal), isozyme S
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TNK2 tyrosine kinase, non-receptor, 2
TRIM38 tripartite motif containing 38
TRPM1 transient receptor potential cation channel, subfamily M, member 1
USP2 ubiquitin specific peptidase 2
VSX1 visual system homeobox 1
XYLB xylulokinase homolog (H. influenzae)
ZBTB33 zinc finger and BTB domain containing 33
ZNF155 zinc finger protein 155
ZNF711 zinc finger protein 711

decreased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADCK4 aarF domain containing kinase 4
ADCY6 adenylate cyclase 6
ADGRE1 adhesion G protein-coupled receptor E1
AHDC1 AT hook, DNA binding motif, containing 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARC activity-regulated cytoskeleton-associated protein
ARHGAP4 Rho GTPase activating protein 4
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATHL1 ATH1, acid trehalase-like 1 (yeast)
C22ORF46 chromosome 22 open reading frame 46
C3AR1 complement component 3a receptor 1
C7ORF43 chromosome 7 open reading frame 43
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CDH18 cadherin 18, type 2
CFHR4 complement factor H-related 4
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CIC capicua transcriptional repressor
CPB1 carboxypeptidase B1 (tissue)
CPB2 carboxypeptidase B2 (plasma)
CRY2 cryptochrome circadian clock 2
CST6 cystatin E/M
CTSO cathepsin O
DLK2 delta-like 2 homolog (Drosophila)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOK5 docking protein 5
ELSPBP1 epididymal sperm binding protein 1
ENO3 enolase 3 (beta, muscle)
ERCC2 excision repair cross-complementation group 2
ERN2 endoplasmic reticulum to nucleus signaling 2
ETNK2 ethanolamine kinase 2
FADS2 fatty acid desaturase 2
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGF16 fibroblast growth factor 16
FLJ22184
FOXI1 forkhead box I1
GLRA1 glycine receptor, alpha 1
GMPR guanosine monophosphate reductase
GPR143 G protein-coupled receptor 143
GPR63 G protein-coupled receptor 63
HCAR3 hydroxycarboxylic acid receptor 3
HOXC8 homeobox C8
IFNA17 interferon, alpha 17
IL2 interleukin 2
IL2RG interleukin 2 receptor, gamma
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KIAA0125 KIAA0125
KIAA1024 KIAA1024
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LOC100286895 cell division cycle 27 homolog pseudogene
LOXL3 lysyl oxidase-like 3
MAST3 microtubule associated serine/threonine kinase 3
MRPL41 mitochondrial ribosomal protein L41
MRPL52 mitochondrial ribosomal protein L52
MTCP1 mature T-cell proliferation 1
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NAT6 N-acetyltransferase 6 (GCN5-related)
NDOR1 NADPH dependent diflavin oxidoreductase 1
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NOD1 nucleotide-binding oligomerization domain containing 1
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NYNRIN NYN domain and retroviral integrase containing
OVGP1 oviductal glycoprotein 1, 120kDa
PHC1 polyhomeotic homolog 1 (Drosophila)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G3 phospholipase A2, group III
PLCD1 phospholipase C, delta 1
PQLC2 PQ loop repeat containing 2
PTPRM protein tyrosine phosphatase, receptor type, M
RASIP1 Ras interacting protein 1
RNF39 ring finger protein 39
S100A9 S100 calcium binding protein A9
SAMD9 sterile alpha motif domain containing 9
SCG2 secretogranin II
SCN1B sodium channel, voltage gated, type I beta subunit
SDC3 syndecan 3
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIX1 SIX homeobox 1
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC16A4 solute carrier family 16, member 4
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SSTR4 somatostatin receptor 4
STX1A syntaxin 1A (brain)
TAS2R4 taste receptor, type 2, member 4
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THAP9 THAP domain containing 9
TMCC2 transmembrane and coiled-coil domain family 2
TMLHE trimethyllysine hydroxylase, epsilon
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSPYL2 TSPY-like 2
UPK3B uroplakin 3B
VN1R1 vomeronasal 1 receptor 1
XDH xanthine dehydrogenase
ZNF484 zinc finger protein 484
ZSCAN2 zinc finger and SCAN domain containing 2