trimethoprim-2307 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the trimethoprim-2307 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
ADAM22 ADAM metallopeptidase domain 22
ADCY10 adenylate cyclase 10 (soluble)
AIRE autoimmune regulator
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AOC2 amine oxidase, copper containing 2 (retina-specific)
AP3B2 adaptor-related protein complex 3, beta 2 subunit
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARR3 arrestin 3, retinal (X-arrestin)
C2ORF27A chromosome 2 open reading frame 27A
C8ORF44 chromosome 8 open reading frame 44
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL25 chemokine (C-C motif) ligand 25
CDC14A cell division cycle 14A
CDK13 cyclin-dependent kinase 13
CDK6 cyclin-dependent kinase 6
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CLEC4M C-type lectin domain family 4, member M
CNTN5 contactin 5
CPNE7 copine VII
CPQ carboxypeptidase Q
CRHR2 corticotropin releasing hormone receptor 2
CST2 cystatin SA
CTSZ cathepsin Z
CYLD cylindromatosis (turban tumor syndrome)
DCAF4 DDB1 and CUL4 associated factor 4
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DGAT1 diacylglycerol O-acyltransferase 1
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ELOVL5 ELOVL fatty acid elongase 5
EXOSC2 exosome component 2
FAM182B family with sequence similarity 182, member B
FGF5 fibroblast growth factor 5
FLJ11292
GPNMB glycoprotein (transmembrane) nmb
GPR143 G protein-coupled receptor 143
GPR45 G protein-coupled receptor 45
GRB10 growth factor receptor-bound protein 10
HNF1B HNF1 homeobox B
HSDL2 hydroxysteroid dehydrogenase like 2
HSF2BP heat shock transcription factor 2 binding protein
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
IL1RAP interleukin 1 receptor accessory protein
KIDINS220 kinase D-interacting substrate, 220kDa
LOXL3 lysyl oxidase-like 3
LTBP2 latent transforming growth factor beta binding protein 2
MED25 mediator complex subunit 25
MFSD7 major facilitator superfamily domain containing 7
MID1 midline 1
MKRN3 makorin ring finger protein 3
MMP25 matrix metallopeptidase 25
MSX2 msh homeobox 2
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYF5 myogenic factor 5
NIPAL3 NIPA-like domain containing 3
NPAS2 neuronal PAS domain protein 2
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR4A1 nuclear receptor subfamily 4, group A, member 1
OCLM oculomedin
OR2H2 olfactory receptor, family 2, subfamily H, member 2
OSBP2 oxysterol binding protein 2
PARVA parvin, alpha
PECAM1 platelet/endothelial cell adhesion molecule 1
PHOX2A paired-like homeobox 2a
PLAU plasminogen activator, urokinase
PML promyelocytic leukemia
PRDM1 PR domain containing 1, with ZNF domain
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCE protein kinase C, epsilon
PSD3 pleckstrin and Sec7 domain containing 3
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PYHIN1 pyrin and HIN domain family, member 1
RASIP1 Ras interacting protein 1
RBMS2 RNA binding motif, single stranded interacting protein 2
RFPL1S RFPL1 antisense RNA 1
RGS14 regulator of G-protein signaling 14
RHBDD3 rhomboid domain containing 3
RNF126P1 ring finger protein 126 pseudogene 1
RORA RAR-related orphan receptor A
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN2 reticulon 2
SEC14L5 SEC14-like 5 (S. cerevisiae)
SERHL2 serine hydrolase-like 2
SIRT4 sirtuin 4
SIX2 SIX homeobox 2
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SPARCL1 SPARC-like 1 (hevin)
SRPK2 SRSF protein kinase 2
STAC SH3 and cysteine rich domain
STYK1 serine/threonine/tyrosine kinase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAAR3 trace amine associated receptor 3 (gene/pseudogene)
TGFB2 transforming growth factor, beta 2
THAP9 THAP domain containing 9
THPO thrombopoietin
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
ANXA2P3 annexin A2 pseudogene 3
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARRB1 arrestin, beta 1
ATP13A2 ATPase type 13A2
BTBD7 BTB (POZ) domain containing 7
C5 complement component 5
CAMK1 calcium/calmodulin-dependent protein kinase I
CAMTA2 calmodulin binding transcription activator 2
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK20 cyclin-dependent kinase 20
CGREF1 cell growth regulator with EF-hand domain 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CIC capicua transcriptional repressor
CLCF1 cardiotrophin-like cytokine factor 1
CLCN6 chloride channel, voltage-sensitive 6
CNN2 calponin 2
CRYBB2P1 crystallin, beta B2 pseudogene 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DMTN dematin actin binding protein
DSCAM Down syndrome cell adhesion molecule
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPHX2 epoxide hydrolase 2, cytoplasmic
EPPK1 epiplakin 1
ERCC4 excision repair cross-complementation group 4
F2R coagulation factor II (thrombin) receptor
FAM114A2 family with sequence similarity 114, member A2
GDAP2 ganglioside induced differentiation associated protein 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLTP glycolipid transfer protein
GNL1 guanine nucleotide binding protein-like 1
GPATCH2L G patch domain containing 2-like
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GSTA4 glutathione S-transferase alpha 4
GSTM5 glutathione S-transferase mu 5
HIST1H1E histone cluster 1, H1e
HPN hepsin
HSPA1L heat shock 70kDa protein 1-like
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFT22 intraflagellar transport 22
IFT81 intraflagellar transport 81
INCENP inner centromere protein antigens 135/155kDa
JADE3 jade family PHD finger 3
KLHL25 kelch-like family member 25
LY6D lymphocyte antigen 6 complex, locus D
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEB2 melanoma antigen family B2
MAP1S microtubule-associated protein 1S
MAPKBP1 mitogen-activated protein kinase binding protein 1
MEFV Mediterranean fever
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MNX1 motor neuron and pancreas homeobox 1
MYO19 myosin XIX
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NLRX1 NLR family member X1
NPIPB3 nuclear pore complex interacting protein family, member B3
NRGN neurogranin (protein kinase C substrate, RC3)
NRSN2 neurensin 2
PADI1 peptidyl arginine deiminase, type I
PARP12 poly (ADP-ribose) polymerase family, member 12
PCDHB13 protocadherin beta 13
PLA2G3 phospholipase A2, group III
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHO2 pleckstrin homology domain containing, family O member 2
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTPRS protein tyrosine phosphatase, receptor type, S
RFTN1 raftlin, lipid raft linker 1
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SIK1 salt-inducible kinase 1
SIX1 SIX homeobox 1
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNAI2 snail family zinc finger 2
SPON2 spondin 2, extracellular matrix protein
SRD5A3 steroid 5 alpha-reductase 3
SRPX sushi-repeat containing protein, X-linked
STAB2 stabilin 2
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TEX40 testis expressed 40
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM115 transmembrane protein 115
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TSSC4 tumor suppressing subtransferable candidate 4
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UNC119 unc-119 homolog (C. elegans)
USP18 ubiquitin specific peptidase 18
VASH2 vasohibin 2
ZBTB48 zinc finger and BTB domain containing 48
ZFHX2 zinc finger homeobox 2
ZFHX3 zinc finger homeobox 3
ZNF134 zinc finger protein 134
ZNF324 zinc finger protein 324
ZNF428 zinc finger protein 428
ZNF652 zinc finger protein 652
ZSCAN26 zinc finger and SCAN domain containing 26