trimethoprim-3678 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the trimethoprim-3678 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ADD2 adducin 2 (beta)
ADGRA2 adhesion G protein-coupled receptor A2
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALPL alkaline phosphatase, liver/bone/kidney
AMH anti-Mullerian hormone
ANXA10 annexin A10
APOL6 apolipoprotein L, 6
ASTN1 astrotactin 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BLZF1 basic leucine zipper nuclear factor 1
BMP5 bone morphogenetic protein 5
C10ORF10 chromosome 10 open reading frame 10
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CCDC57 coiled-coil domain containing 57
CD6 CD6 molecule
CDC25C cell division cycle 25C
CFAP70 cilia and flagella associated protein 70
CHI3L2 chitinase 3-like 2
CYTH3 cytohesin 3
DISC1 disrupted in schizophrenia 1
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
EDRF1 erythroid differentiation regulatory factor 1
EMC3 ER membrane protein complex subunit 3
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EXOSC2 exosome component 2
EXPH5 exophilin 5
FAM212B family with sequence similarity 212, member B
FGF16 fibroblast growth factor 16
FLT1 fms-related tyrosine kinase 1
FRMPD4 FERM and PDZ domain containing 4
FRZB frizzled-related protein
G6PC2 glucose-6-phosphatase, catalytic, 2
GCKR glucokinase (hexokinase 4) regulator
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GP2 glycoprotein 2 (zymogen granule membrane)
GTDC1 glycosyltransferase-like domain containing 1
HCFC1 host cell factor C1
HIF3A hypoxia inducible factor 3, alpha subunit
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HPGDS hematopoietic prostaglandin D synthase
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
IFT140 intraflagellar transport 140
IKZF4 IKAROS family zinc finger 4 (Eos)
IL12B interleukin 12B
IL32 interleukin 32
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIAA0319L KIAA0319-like
KLK13 kallikrein-related peptidase 13
LEPR leptin receptor
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMX1B LIM homeobox transcription factor 1, beta
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LY6G6C lymphocyte antigen 6 complex, locus G6C
LYRM9 LYR motif containing 9
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MUC3B mucin 3B, cell surface associated
MYO1F myosin IF
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NRG1 neuregulin 1
OTOR otoraplin
PCDHB13 protocadherin beta 13
PIP prolactin-induced protein
PLA2G1B phospholipase A2, group IB (pancreas)
PLEKHS1 pleckstrin homology domain containing, family S member 1
POU5F1B POU class 5 homeobox 1B
PTGDR2 prostaglandin D2 receptor 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB26 RAB26, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RAD50 RAD50 homolog (S. cerevisiae)
RBM5 RNA binding motif protein 5
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCN3B sodium channel, voltage gated, type III beta subunit
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SLCO5A1 solute carrier organic anion transporter family, member 5A1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPANXC SPANX family, member C
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
ST7L suppression of tumorigenicity 7 like
STRN3 striatin, calmodulin binding protein 3
SYT2 synaptotagmin II
T T, brachyury homolog (mouse)
TMEM259 transmembrane protein 259
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TOX thymocyte selection-associated high mobility group box
TRO trophinin
XYLT1 xylosyltransferase I
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF222 zinc finger protein 222
ZNF345 zinc finger protein 345

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADGRL2 adhesion G protein-coupled receptor L2
ADTRP androgen-dependent TFPI-regulating protein
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
BMP4 bone morphogenetic protein 4
C11ORF80 chromosome 11 open reading frame 80
C14ORF79 chromosome 14 open reading frame 79
C17ORF53 chromosome 17 open reading frame 53
C17ORF80 chromosome 17 open reading frame 80
C1ORF105 chromosome 1 open reading frame 105
C4ORF29 chromosome 4 open reading frame 29
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CARD8 caspase recruitment domain family, member 8
CCDC121 coiled-coil domain containing 121
CCDC71 coiled-coil domain containing 71
CD70 CD70 molecule
CDON cell adhesion associated, oncogene regulated
CES3 carboxylesterase 3
CLCN6 chloride channel, voltage-sensitive 6
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CNTFR ciliary neurotrophic factor receptor
COBL cordon-bleu WH2 repeat protein
COL16A1 collagen, type XVI, alpha 1
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CORO2A coronin, actin binding protein, 2A
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAL4 dynein, axonemal, light chain 4
DSCAM Down syndrome cell adhesion molecule
DUSP2 dual specificity phosphatase 2
EDC3 enhancer of mRNA decapping 3
ERCC5 excision repair cross-complementation group 5
ERO1LB ERO1-like beta (S. cerevisiae)
ETNK2 ethanolamine kinase 2
FAM120C family with sequence similarity 120C
GALK1 galactokinase 1
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR3 G protein-coupled receptor 3
GREB1L growth regulation by estrogen in breast cancer-like
HDAC11 histone deacetylase 11
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H1T histone cluster 1, H1t
IL17RB interleukin 17 receptor B
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIF13A kinesin family member 13A
LIMD2 LIM domain containing 2
LRRC61 leucine rich repeat containing 61
MBTPS2 membrane-bound transcription factor peptidase, site 2
MEFV Mediterranean fever
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NIPAL2 NIPA-like domain containing 2
NOL12 nucleolar protein 12
NPFFR1 neuropeptide FF receptor 1
NPHP1 nephronophthisis 1 (juvenile)
PC pyruvate carboxylase
PDZK1 PDZ domain containing 1
PGP phosphoglycolate phosphatase
PICK1 protein interacting with PRKCA 1
PODNL1 podocan-like 1
PTK6 protein tyrosine kinase 6
QTRT1 queuine tRNA-ribosyltransferase 1
RNF122 ring finger protein 122
RNF2 ring finger protein 2
RPA4 replication protein A4, 30kDa
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SETD8 SET domain containing (lysine methyltransferase) 8
SLC46A3 solute carrier family 46, member 3
SMO smoothened, frizzled class receptor
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
STAB2 stabilin 2
STK16 serine/threonine kinase 16
SYCP2 synaptonemal complex protein 2
SYT17 synaptotagmin XVII
TESPA1 thymocyte expressed, positive selection associated 1
TFCP2L1 transcription factor CP2-like 1
TMEM40 transmembrane protein 40
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
VASH1 vasohibin 1
WDR33 WD repeat domain 33
ZC2HC1C zinc finger, C2HC-type containing 1C
ZC3H12A zinc finger CCCH-type containing 12A
ZNF141 zinc finger protein 141
ZNF639 zinc finger protein 639
ZNF747 zinc finger protein 747
ZNF768 zinc finger protein 768