trimethylcolchicinic acid-2146 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the trimethylcolchicinic acid-2146 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACACB acetyl-CoA carboxylase beta
APAF1 apoptotic peptidase activating factor 1
APC adenomatous polyposis coli
APOH apolipoprotein H (beta-2-glycoprotein I)
ATAD2B ATPase family, AAA domain containing 2B
ATF3 activating transcription factor 3
ATRN attractin
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CCNK cyclin K
CD59 CD59 molecule, complement regulatory protein
CD79B CD79b molecule, immunoglobulin-associated beta
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CPNE7 copine VII
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CUL5 cullin 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDR1 discoidin domain receptor tyrosine kinase 1
E2F1 E2F transcription factor 1
EGR1 early growth response 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FAM131A family with sequence similarity 131, member A
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAL3ST4 galactose-3-O-sulfotransferase 4
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GSK3A glycogen synthase kinase 3 alpha
HCAR3 hydroxycarboxylic acid receptor 3
HIC2 hypermethylated in cancer 2
HIPK3 homeodomain interacting protein kinase 3
HIST1H2BI histone cluster 1, H2bi
HIST1H2BN histone cluster 1, H2bn
HLA-DOA major histocompatibility complex, class II, DO alpha
IFT140 intraflagellar transport 140
IL1B interleukin 1, beta
JUN jun proto-oncogene
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA0319L KIAA0319-like
KIAA1109 KIAA1109
KIDINS220 kinase D-interacting substrate, 220kDa
LOC100131510 uncharacterized LOC100131510
LOC257152 uncharacterized LOC257152
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP4 microtubule-associated protein 4
MARC1 mitochondrial amidoxime reducing component 1
MCL1 myeloid cell leukemia 1
MCTP2 multiple C2 domains, transmembrane 2
MED28 mediator complex subunit 28
MFAP3 microfibrillar-associated protein 3
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MTAP methylthioadenosine phosphorylase
NIPAL2 NIPA-like domain containing 2
NPY6R neuropeptide Y receptor Y6 (pseudogene)
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDIA2 protein disulfide isomerase family A, member 2
PDZK1IP1 PDZK1 interacting protein 1
PEX11A peroxisomal biogenesis factor 11 alpha
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLD1 phospholipase D1, phosphatidylcholine-specific
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POU5F1B POU class 5 homeobox 1B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSD3 pleckstrin and Sec7 domain containing 3
PTEN phosphatase and tensin homolog
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RBMS3 RNA binding motif, single stranded interacting protein 3
RND1 Rho family GTPase 1
RUNX1 runt-related transcription factor 1
SAA3P serum amyloid A3 pseudogene
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAMP5 secretory carrier membrane protein 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGPP1 sphingosine-1-phosphate phosphatase 1
SKIL SKI-like proto-oncogene
SLC16A4 solute carrier family 16, member 4
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPAG8 sperm associated antigen 8
SPTAN1 spectrin, alpha, non-erythrocytic 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAF1 TNF receptor-associated factor 1
TSC22D1 TSC22 domain family, member 1
UBR2 ubiquitin protein ligase E3 component n-recognin 2
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WBP4 WW domain binding protein 4
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WRAP53 WD repeat containing, antisense to TP53
ZBTB22 zinc finger and BTB domain containing 22
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACAD10 acyl-CoA dehydrogenase family, member 10
ALS2CL ALS2 C-terminal like
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ATAT1 alpha tubulin acetyltransferase 1
CA11 carbonic anhydrase XI
CARF calcium responsive transcription factor
CBX7 chromobox homolog 7
CCDC106 coiled-coil domain containing 106
CCDC176 coiled-coil domain containing 176
CCDC85C coiled-coil domain containing 85C
CCDC9 coiled-coil domain containing 9
CCRL2 chemokine (C-C motif) receptor-like 2
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD3D CD3d molecule, delta (CD3-TCR complex)
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDKL3 cyclin-dependent kinase-like 3
CENPT centromere protein T
CES3 carboxylesterase 3
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CIDEB cell death-inducing DFFA-like effector b
CSF1R colony stimulating factor 1 receptor
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCR2 chemokine (C-X-C motif) receptor 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DTX4 deltex 4, E3 ubiquitin ligase
DUS1L dihydrouridine synthase 1-like (S. cerevisiae)
EFNA3 ephrin-A3
EPHB6 EPH receptor B6
FCHO1 FCH domain only 1
FKBP9 FK506 binding protein 9, 63 kDa
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
HIST1H2AE histone cluster 1, H2ae
HIST1H4C histone cluster 1, H4c
HIST1H4J histone cluster 1, H4j
IFT81 intraflagellar transport 81
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KIF20A kinesin family member 20A
KLF1 Kruppel-like factor 1 (erythroid)
LYPLA2P1 lysophospholipase II pseudogene 1
MANSC1 MANSC domain containing 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
METTL21B methyltransferase like 21B
MGC12488
MST1 macrophage stimulating 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NBEAL2 neurobeachin-like 2
NECAB3 N-terminal EF-hand calcium binding protein 3
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OXCT2 3-oxoacid CoA transferase 2
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PADI1 peptidyl arginine deiminase, type I
PARG poly (ADP-ribose) glycohydrolase
PCDHGB5 protocadherin gamma subfamily B, 5
PLK1 polo-like kinase 1
PMFBP1 polyamine modulated factor 1 binding protein 1
POLL polymerase (DNA directed), lambda
PROS1 protein S (alpha)
PSKH1 protein serine kinase H1
PSRC1 proline/serine-rich coiled-coil 1
RAB13 RAB13, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RABL6 RAB, member RAS oncogene family-like 6
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RNF2 ring finger protein 2
ROGDI rogdi homolog (Drosophila)
RPP25 ribonuclease P/MRP 25kDa subunit
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SEPW1 selenoprotein W, 1
SLC22A14 solute carrier family 22, member 14
SLC44A1 solute carrier family 44 (choline transporter), member 1
SP4 Sp4 transcription factor
STAT5A signal transducer and activator of transcription 5A
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TEC tec protein tyrosine kinase
TMEM104 transmembrane protein 104
TMEM110 transmembrane protein 110
TMEM184B transmembrane protein 184B
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TPRA1 transmembrane protein, adipocyte asscociated 1
TSPAN32 tetraspanin 32
TTC23 tetratricopeptide repeat domain 23
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBE2C ubiquitin-conjugating enzyme E2C
UBIAD1 UbiA prenyltransferase domain containing 1
UBQLN4 ubiquilin 4
YY2 YY2 transcription factor
ZNF749 zinc finger protein 749
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