trioxysalen-2516 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the trioxysalen-2516 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ANGPT4 angiopoietin 4
ATN1 atrophin 1
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHMT betaine--homocysteine S-methyltransferase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALCA calcitonin-related polypeptide alpha
CALD1 caldesmon 1
CAMK1G calcium/calmodulin-dependent protein kinase IG
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCL16 chemokine (C-C motif) ligand 16
CDC14A cell division cycle 14A
CDC42 cell division cycle 42
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CLCN5 chloride channel, voltage-sensitive 5
CYHR1 cysteine/histidine-rich 1
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DSG3 desmoglein 3
EFNA5 ephrin-A5
ERAP1 endoplasmic reticulum aminopeptidase 1
ESR1 estrogen receptor 1
FGFR3 fibroblast growth factor receptor 3
FLJ11292
FXYD6 FXYD domain containing ion transport regulator 6
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GEM GTP binding protein overexpressed in skeletal muscle
GMPR guanosine monophosphate reductase
GPC1 glypican 1
GRIA1 glutamate receptor, ionotropic, AMPA 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HAS2 hyaluronan synthase 2
HIST1H2AJ histone cluster 1, H2aj
HIST1H3G histone cluster 1, H3g
HOXB1 homeobox B1
HOXB3 homeobox B3
ICA1 islet cell autoantigen 1, 69kDa
IGFBP5 insulin-like growth factor binding protein 5
IL17A interleukin 17A
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL6ST interleukin 6 signal transducer
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
KHSRP KH-type splicing regulatory protein
KIAA1109 KIAA1109
LAMC3 laminin, gamma 3
MARC1 mitochondrial amidoxime reducing component 1
MCAM melanoma cell adhesion molecule
MED16 mediator complex subunit 16
MIR622 microRNA 622
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NDOR1 NADPH dependent diflavin oxidoreductase 1
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NEFM neurofilament, medium polypeptide
NOTCH3 notch 3
NXPH4 neurexophilin 4
OR7A17 olfactory receptor, family 7, subfamily A, member 17
PADI1 peptidyl arginine deiminase, type I
PHC3 polyhomeotic homolog 3 (Drosophila)
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PKP1 plakophilin 1
PRDM1 PR domain containing 1, with ZNF domain
PRX periaxin
PTAFR platelet-activating factor receptor
PTGIS prostaglandin I2 (prostacyclin) synthase
PXDN peroxidasin
RHOD ras homolog family member D
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RPE65 retinal pigment epithelium-specific protein 65kDa
SAMD14 sterile alpha motif domain containing 14
SEC14L1 SEC14-like 1 (S. cerevisiae)
SIX2 SIX homeobox 2
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC35G2 solute carrier family 35, member G2
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SPO11 SPO11 meiotic protein covalently bound to DSB
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SRSF7 serine/arginine-rich splicing factor 7
SSTR4 somatostatin receptor 4
STARD13 StAR-related lipid transfer (START) domain containing 13
SVIL supervillin
TADA3 transcriptional adaptor 3
TEF thyrotrophic embryonic factor
TIMP2 TIMP metallopeptidase inhibitor 2
TMPRSS15 transmembrane protease, serine 15
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TP73 tumor protein p73
VPRBP Vpr (HIV-1) binding protein
VTN vitronectin
ZER1 zyg-11 related, cell cycle regulator
ZNF235 zinc finger protein 235
ZNF440 zinc finger protein 440
ZNF556 zinc finger protein 556

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADORA3 adenosine A3 receptor
ANXA3 annexin A3
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ARSB arylsulfatase B
ASB7 ankyrin repeat and SOCS box containing 7
BAG4 BCL2-associated athanogene 4
C1ORF56 chromosome 1 open reading frame 56
C21ORF91 chromosome 21 open reading frame 91
C7ORF43 chromosome 7 open reading frame 43
C9ORF91 chromosome 9 open reading frame 91
CA5BP1 carbonic anhydrase VB pseudogene 1
CCL20 chemokine (C-C motif) ligand 20
CD69 CD69 molecule
CD82 CD82 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CENPC centromere protein C
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1
DDIT3 DNA-damage-inducible transcript 3
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DOCK4 dedicator of cytokinesis 4
ECI1 enoyl-CoA delta isomerase 1
ERCC6L excision repair cross-complementation group 6-like
FAM127A family with sequence similarity 127, member A
FANCF Fanconi anemia, complementation group F
FBXL15 F-box and leucine-rich repeat protein 15
FEM1C fem-1 homolog c (C. elegans)
FMO4 flavin containing monooxygenase 4
GALE UDP-galactose-4-epimerase
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GIPC1 GIPC PDZ domain containing family, member 1
GLTP glycolipid transfer protein
GMEB1 glucocorticoid modulatory element binding protein 1
GRAMD1B GRAM domain containing 1B
GSTCD glutathione S-transferase, C-terminal domain containing
HHLA3 HERV-H LTR-associating 3
HIST1H2BI histone cluster 1, H2bi
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HPSE heparanase
HSPB6 heat shock protein, alpha-crystallin-related, B6
IL18 interleukin 18
INF2 inverted formin, FH2 and WH2 domain containing
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNK5 potassium channel, two pore domain subfamily K, member 5
KDM7A lysine (K)-specific demethylase 7A
KDM8 lysine (K)-specific demethylase 8
KPNA4 karyopherin alpha 4 (importin alpha 3)
MAPKBP1 mitogen-activated protein kinase binding protein 1
METTL8 methyltransferase like 8
MOCS3 molybdenum cofactor synthesis 3
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDZD7 PDZ domain containing 7
PFKM phosphofructokinase, muscle
PLA2G15 phospholipase A2, group XV
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTTG3P pituitary tumor-transforming 3, pseudogene
QTRT1 queuine tRNA-ribosyltransferase 1
RARS arginyl-tRNA synthetase
RHOBTB2 Rho-related BTB domain containing 2
RINT1 RAD50 interactor 1
RNF2 ring finger protein 2
RPA4 replication protein A4, 30kDa
RRAS related RAS viral (r-ras) oncogene homolog
SCUBE3 signal peptide, CUB domain, EGF-like 3
SGMS1 sphingomyelin synthase 1
SIRT1 sirtuin 1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SNRPN small nuclear ribonucleoprotein polypeptide N
SNX16 sorting nexin 16
SPATA2L spermatogenesis associated 2-like
SPINT1 serine peptidase inhibitor, Kunitz type 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TET3 tet methylcytosine dioxygenase 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMC5 transmembrane channel-like 5
TMEM177 transmembrane protein 177
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTC33 tetratricopeptide repeat domain 33
UNC119 unc-119 homolog (C. elegans)
WWC3 WWC family member 3
ZBTB10 zinc finger and BTB domain containing 10
ZNF329 zinc finger protein 329
ZNF428 zinc finger protein 428
ZNF747 zinc finger protein 747
ZNF8 zinc finger protein 8
ZNHIT2 zinc finger, HIT-type containing 2