triprolidine-7008 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the triprolidine-7008 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ACVR2B activin A receptor, type IIB
ADGRL1 adhesion G protein-coupled receptor L1
ADM2 adrenomedullin 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APP amyloid beta (A4) precursor protein
ARNT aryl hydrocarbon receptor nuclear translocator
BCL2L2 BCL2-like 2
C21ORF2 chromosome 21 open reading frame 2
CA5BP1 carbonic anhydrase VB pseudogene 1
CBX8 chromobox homolog 8
CCDC186 coiled-coil domain containing 186
CCP110 centriolar coiled coil protein 110kDa
CCPG1 cell cycle progression 1
COPZ2 coatomer protein complex, subunit zeta 2
CPM carboxypeptidase M
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DCTN1 dynactin 1
DTNA dystrobrevin, alpha
DUSP2 dual specificity phosphatase 2
EDNRA endothelin receptor type A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EVA1B eva-1 homolog B (C. elegans)
FAM169A family with sequence similarity 169, member A
FBXO11 F-box protein 11
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FKBP10 FK506 binding protein 10, 65 kDa
FOXO1 forkhead box O1
FZD7 frizzled class receptor 7
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GLCE glucuronic acid epimerase
GLS glutaminase
GMEB1 glucocorticoid modulatory element binding protein 1
GOLGA8B golgin A8 family, member B
HBP1 HMG-box transcription factor 1
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IL23A interleukin 23, alpha subunit p19
IL4R interleukin 4 receptor
IL6R interleukin 6 receptor
IRF5 interferon regulatory factor 5
KIF1C kinesin family member 1C
KIF3C kinesin family member 3C
KLF2 Kruppel-like factor 2
LIG3 ligase III, DNA, ATP-dependent
LZTR1 leucine-zipper-like transcription regulator 1
MBD1 methyl-CpG binding domain protein 1
MEFV Mediterranean fever
MOCS1 molybdenum cofactor synthesis 1
MUM1 melanoma associated antigen (mutated) 1
NEB nebulin
NF2 neurofibromin 2 (merlin)
NFE2L3 nuclear factor, erythroid 2-like 3
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM7 PDZ and LIM domain 7 (enigma)
PER3 period circadian clock 3
PEX5 peroxisomal biogenesis factor 5
PGAP1 post-GPI attachment to proteins 1
PGPEP1 pyroglutamyl-peptidase I
PHLDB1 pleckstrin homology-like domain, family B, member 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRPF18 pre-mRNA processing factor 18
PRSS22 protease, serine, 22
PTPRA protein tyrosine phosphatase, receptor type, A
RALGDS ral guanine nucleotide dissociation stimulator
RANGAP1 Ran GTPase activating protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
REST RE1-silencing transcription factor
RNF122 ring finger protein 122
RNF39 ring finger protein 39
RRBP1 ribosome binding protein 1
S100A13 S100 calcium binding protein A13
SASH1 SAM and SH3 domain containing 1
SCHIP1 schwannomin interacting protein 1
SETX senataxin
SIGLEC5 sialic acid binding Ig-like lectin 5
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SNX13 sorting nexin 13
SPHK1 sphingosine kinase 1
STAT5B signal transducer and activator of transcription 5B
STK17B serine/threonine kinase 17b
TLDC1 TBC/LysM-associated domain containing 1
TRAPPC10 trafficking protein particle complex 10
VDAC3 voltage-dependent anion channel 3
ZBTB14 zinc finger and BTB domain containing 14
ZBTB22 zinc finger and BTB domain containing 22
ZNF227 zinc finger protein 227
ZNF230 zinc finger protein 230
ZNF287 zinc finger protein 287
ZNF41 zinc finger protein 41
ZNF592 zinc finger protein 592

decreased expression

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APH1A APH1A gamma secretase subunit
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ATAD5 ATPase family, AAA domain containing 5
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAX BCL2-associated X protein
BBS10 Bardet-Biedl syndrome 10
BIK BCL2-interacting killer (apoptosis-inducing)
C17ORF62 chromosome 17 open reading frame 62
C19ORF40 chromosome 19 open reading frame 40
C2CD2 C2 calcium-dependent domain containing 2
CALCOCO1 calcium binding and coiled-coil domain 1
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASZ1 castor zinc finger 1
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
CEP170B centrosomal protein 170B
CLASP1 cytoplasmic linker associated protein 1
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DENND5A DENN/MADD domain containing 5A
E2F3 E2F transcription factor 3
EPN3 epsin 3
EPPK1 epiplakin 1
FAM86C1 family with sequence similarity 86, member C1
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
GINS4 GINS complex subunit 4 (Sld5 homolog)
GMIP GEM interacting protein
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GYS1 glycogen synthase 1 (muscle)
HIRA histone cell cycle regulator
HIST1H2AE histone cluster 1, H2ae
HIST1H2AJ histone cluster 1, H2aj
HMOX1 heme oxygenase 1
ICK intestinal cell (MAK-like) kinase
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
KIFC1 kinesin family member C1
KIZ kizuna centrosomal protein
KLHL12 kelch-like family member 12
KRI1 KRI1 homolog (S. cerevisiae)
LRRC61 leucine rich repeat containing 61
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAMLD1 mastermind-like domain containing 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPKBP1 mitogen-activated protein kinase binding protein 1
MB myoglobin
MLYCD malonyl-CoA decarboxylase
MTCL1 microtubule crosslinking factor 1
MTMR11 myotubularin related protein 11
MXD3 MAX dimerization protein 3
NOTCH1 notch 1
NUBPL nucleotide binding protein-like
PBLD phenazine biosynthesis-like protein domain containing
PELI1 pellino E3 ubiquitin protein ligase 1
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RAD54L RAD54-like (S. cerevisiae)
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RECQL4 RecQ protein-like 4
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RIBC2 RIB43A domain with coiled-coils 2
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SETD8 SET domain containing (lysine methyltransferase) 8
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC38A10 solute carrier family 38, member 10
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SP140L SP140 nuclear body protein-like
STAG3 stromal antigen 3
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TCTA T-cell leukemia translocation altered
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TESK1 testis-specific kinase 1
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TMEM57 transmembrane protein 57
TRAPPC11 trafficking protein particle complex 11
TRAPPC13 trafficking protein particle complex 13
TTLL1 tubulin tyrosine ligase-like family member 1
TWF2 twinfilin actin binding protein 2
UBE2L6 ubiquitin-conjugating enzyme E2L 6
URGCP upregulator of cell proliferation
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
YEATS2 YEATS domain containing 2
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZDHHC18 zinc finger, DHHC-type containing 18
ZFAND3 zinc finger, AN1-type domain 3
ZNF652 zinc finger protein 652
ZNF8 zinc finger protein 8