troglitazone-1070 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the troglitazone-1070 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKHD1 ankyrin repeat and KH domain containing 1
ARMCX1 armadillo repeat containing, X-linked 1
ARRB1 arrestin, beta 1
ATF2 activating transcription factor 2
ATF3 activating transcription factor 3
BPHL biphenyl hydrolase-like (serine hydrolase)
BRAF B-Raf proto-oncogene, serine/threonine kinase
C17ORF80 chromosome 17 open reading frame 80
CASP6 caspase 6, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLSPN claspin
CREM cAMP responsive element modulator
CSRP2 cysteine and glycine-rich protein 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DCAF7 DDB1 and CUL4 associated factor 7
DDIT3 DNA-damage-inducible transcript 3
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
FA2H fatty acid 2-hydroxylase
FAM174B family with sequence similarity 174, member B
FAM53B family with sequence similarity 53, member B
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial
FGFR2 fibroblast growth factor receptor 2
FKBP8 FK506 binding protein 8, 38kDa
FOXD1 forkhead box D1
FYN FYN proto-oncogene, Src family tyrosine kinase
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GUSBP3 glucuronidase, beta pseudogene 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H3B histone cluster 1, H3b
HLA-J major histocompatibility complex, class I, J (pseudogene)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA5 homeobox A5
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IER2 immediate early response 2
INO80B INO80 complex subunit B
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
LDLR low density lipoprotein receptor
LRRC14 leucine rich repeat containing 14
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MR1 major histocompatibility complex, class I-related
MRPS12 mitochondrial ribosomal protein S12
MT1F metallothionein 1F
MUM1 melanoma associated antigen (mutated) 1
MYL5 myosin, light chain 5, regulatory
MZF1 myeloid zinc finger 1
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PHF21A PHD finger protein 21A
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRR14L proline rich 14-like
PTPRA protein tyrosine phosphatase, receptor type, A
RAB27A RAB27A, member RAS oncogene family
RANBP3 RAN binding protein 3
RCAN1 regulator of calcineurin 1
RNF126 ring finger protein 126
SAT1 spermidine/spermine N1-acetyltransferase 1
SDF2L1 stromal cell-derived factor 2-like 1
SORBS3 sorbin and SH3 domain containing 3
SOX9 SRY (sex determining region Y)-box 9
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
SPN sialophorin
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STK19 serine/threonine kinase 19
TBC1D17 TBC1 domain family, member 17
TCAF1 TRPM8 channel-associated factor 1
TDRD3 tudor domain containing 3
TMEM161A transmembrane protein 161A
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPGS2 tubulin polyglutamylase complex subunit 2
TSPAN3 tetraspanin 3
TXNRD2 thioredoxin reductase 2
USF2 upstream transcription factor 2, c-fos interacting
USP12 ubiquitin specific peptidase 12
VAMP4 vesicle-associated membrane protein 4
VGF VGF nerve growth factor inducible
ZBED1 zinc finger, BED-type containing 1
ZNF134 zinc finger protein 134
ZNF250 zinc finger protein 250
ZNF580 zinc finger protein 580

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ADGRL2 adhesion G protein-coupled receptor L2
AFG3L2 AFG3-like AAA ATPase 2
AGO1 argonaute RISC catalytic component 1
ARHGAP5 Rho GTPase activating protein 5
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASPHD1 aspartate beta-hydroxylase domain containing 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BACE1 beta-site APP-cleaving enzyme 1
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C10ORF88 chromosome 10 open reading frame 88
C16ORF59 chromosome 16 open reading frame 59
C1ORF115 chromosome 1 open reading frame 115
C2CD2 C2 calcium-dependent domain containing 2
CCNJ cyclin J
CCNT1 cyclin T1
CD3EAP CD3e molecule, epsilon associated protein
CDK8 cyclin-dependent kinase 8
CEP85 centrosomal protein 85kDa
CHKB choline kinase beta
CLASRP CLK4-associating serine/arginine rich protein
COLGALT1 collagen beta(1-O)galactosyltransferase 1
CPTP ceramide-1-phosphate transfer protein
CRIPT cysteine-rich PDZ-binding protein
DAAM1 dishevelled associated activator of morphogenesis 1
DBR1 debranching RNA lariats 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNA2 DNA replication helicase/nuclease 2
E2F8 E2F transcription factor 8
EGLN1 egl-9 family hypoxia-inducible factor 1
EIF1B eukaryotic translation initiation factor 1B
ERBB2IP erbb2 interacting protein
FAM188A family with sequence similarity 188, member A
FBXL4 F-box and leucine-rich repeat protein 4
FOXJ2 forkhead box J2
GALT galactose-1-phosphate uridylyltransferase
INF2 inverted formin, FH2 and WH2 domain containing
INSIG2 insulin induced gene 2
ITGA6 integrin, alpha 6
JADE1 jade family PHD finger 1
JADE3 jade family PHD finger 3
KAT2A K(lysine) acetyltransferase 2A
KIAA0141 KIAA0141
KIAA1551 KIAA1551
KIF20B kinesin family member 20B
KLHL21 kelch-like family member 21
KLHL26 kelch-like family member 26
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
LRP3 low density lipoprotein receptor-related protein 3
LRP5 low density lipoprotein receptor-related protein 5
MAD2L1BP MAD2L1 binding protein
MB myoglobin
MBOAT2 membrane bound O-acyltransferase domain containing 2
MCM9 minichromosome maintenance complex component 9
MOCS3 molybdenum cofactor synthesis 3
MTERF1 mitochondrial transcription termination factor 1
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NAP1L2 nucleosome assembly protein 1-like 2
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEO1 neogenin 1
NHLRC2 NHL repeat containing 2
NIP7 NIP7, nucleolar pre-rRNA processing protein
NPY1R neuropeptide Y receptor Y1
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
OGFRL1 opioid growth factor receptor-like 1
PAXBP1 PAX3 and PAX7 binding protein 1
PHACTR4 phosphatase and actin regulator 4
PYGB phosphorylase, glycogen; brain
RABGGTA Rab geranylgeranyltransferase, alpha subunit
RAD51AP1 RAD51 associated protein 1
RANBP17 RAN binding protein 17
RHOC ras homolog family member C
RINT1 RAD50 interactor 1
RLF rearranged L-myc fusion
RNF38 ring finger protein 38
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A6 S100 calcium binding protein A6
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SNIP1 Smad nuclear interacting protein 1
TGS1 trimethylguanosine synthase 1
TMEM168 transmembrane protein 168
TMEM38B transmembrane protein 38B
TOR3A torsin family 3, member A
TRAF5 TNF receptor-associated factor 5
TTC26 tetratricopeptide repeat domain 26
TULP4 tubby like protein 4
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae)
WDR44 WD repeat domain 44
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZMAT3 zinc finger, matrin-type 3
ZNF273 zinc finger protein 273
ZNF85 zinc finger protein 85
ZNHIT2 zinc finger, HIT-type containing 2