troglitazone-462 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the troglitazone-462 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
ACRV1 acrosomal vesicle protein 1
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADAP2 ArfGAP with dual PH domains 2
AGRN agrin
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMIGO2 adhesion molecule with Ig-like domain 2
ANG angiogenin, ribonuclease, RNase A family, 5
ANGPTL4 angiopoietin-like 4
AQP3 aquaporin 3 (Gill blood group)
ARSF arylsulfatase F
ASB13 ankyrin repeat and SOCS box containing 13
ATP13A3 ATPase type 13A3
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
AXIN1 axin 1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BAMBI BMP and activin membrane-bound inhibitor
BMP10 bone morphogenetic protein 10
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CD5 CD5 molecule
CDH18 cadherin 18, type 2
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC11A C-type lectin domain family 11, member A
CNTD2 cyclin N-terminal domain containing 2
COQ3 coenzyme Q3 methyltransferase
CSN2 casein beta
DLL3 delta-like 3 (Drosophila)
DRP2 dystrophin related protein 2
DTX4 deltex 4, E3 ubiquitin ligase
ESR2 estrogen receptor 2 (ER beta)
EXTL2 exostosin-like glycosyltransferase 2
FABP4 fatty acid binding protein 4, adipocyte
FAM214B family with sequence similarity 214, member B
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FGF4 fibroblast growth factor 4
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GK glycerol kinase
GREB1L growth regulation by estrogen in breast cancer-like
HFE hemochromatosis
HHIPL2 HHIP-like 2
ICAM1 intercellular adhesion molecule 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INA internexin neuronal intermediate filament protein, alpha
JUN jun proto-oncogene
KLHL25 kelch-like family member 25
KLHL28 kelch-like family member 28
KRT17 keratin 17, type I
LHX3 LIM homeobox 3
LOC729164 hCG1732469
LPAR2 lysophosphatidic acid receptor 2
LPIN1 lipin 1
LUZP4 leucine zipper protein 4
MAN1C1 mannosidase, alpha, class 1C, member 1
MRPL41 mitochondrial ribosomal protein L41
NDRG2 NDRG family member 2
NKIRAS2 NFKB inhibitor interacting Ras-like 2
NUP214 nucleoporin 214kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
ORAI2 ORAI calcium release-activated calcium modulator 2
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PARVA parvin, alpha
PAX1 paired box 1
PEX11A peroxisomal biogenesis factor 11 alpha
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PIGR polymeric immunoglobulin receptor
PKNOX2 PBX/knotted 1 homeobox 2
PLAC1 placenta-specific 1
PLIN2 perilipin 2
PLSCR4 phospholipid scramblase 4
PRKCD protein kinase C, delta
PSG6 pregnancy specific beta-1-glycoprotein 6
PSIP1 PC4 and SFRS1 interacting protein 1
RAB15 RAB15, member RAS oncogene family
RARB retinoic acid receptor, beta
RARG retinoic acid receptor, gamma
RBM47 RNA binding motif protein 47
RGS4 regulator of G-protein signaling 4
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae)
RNF39 ring finger protein 39
RSL1D1 ribosomal L1 domain containing 1
RUNX1 runt-related transcription factor 1
SBNO1 strawberry notch homolog 1 (Drosophila)
SCAMP1 secretory carrier membrane protein 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SETMAR SET domain and mariner transposase fusion gene
SFTPB surfactant protein B
SIM2 single-minded family bHLH transcription factor 2
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC35F6 solute carrier family 35, member F6
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
TMCC1 transmembrane and coiled-coil domain family 1
VAV1 vav 1 guanine nucleotide exchange factor
WIZ widely interspaced zinc finger motifs

decreased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ATP11B ATPase, class VI, type 11B
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide
ATXN2 ataxin 2
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BMPR1B bone morphogenetic protein receptor, type IB
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BTBD2 BTB (POZ) domain containing 2
CCDC53 coiled-coil domain containing 53
CCDC87 coiled-coil domain containing 87
CCP110 centriolar coiled coil protein 110kDa
CDC45 cell division cycle 45
CDKN2AIP CDKN2A interacting protein
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHKB choline kinase beta
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLDN17 claudin 17
COL19A1 collagen, type XIX, alpha 1
COL5A2 collagen, type V, alpha 2
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYR61 cysteine-rich, angiogenic inducer, 61
DCLRE1A DNA cross-link repair 1A
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
EMC9 ER membrane protein complex subunit 9
ESM1 endothelial cell-specific molecule 1
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGF6 fibroblast growth factor 6
FKBPL FK506 binding protein like
FZD8 frizzled class receptor 8
GAGE3 G antigen 3
GSTT1 glutathione S-transferase theta 1
H2AFY2 H2A histone family, member Y2
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIRIP3 HIRA interacting protein 3
HOXB1 homeobox B1
HP1BP3 heterochromatin protein 1, binding protein 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL18 interleukin 18
IL4R interleukin 4 receptor
INHBB inhibin, beta B
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KIF18A kinesin family member 18A
KIFC1 kinesin family member C1
KRT15 keratin 15, type I
LAMP3 lysosomal-associated membrane protein 3
LOC79999 uncharacterized LOC79999
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPK3 mitogen-activated protein kinase 3
MEGF6 multiple EGF-like-domains 6
MICALL2 MICAL-like 2
MON1B MON1 secretory trafficking family member B
MTERF4 mitochondrial transcription termination factor 4
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
MYO1D myosin ID
NTSR1 neurotensin receptor 1 (high affinity)
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAQR4 progestin and adipoQ receptor family member IV
PLAU plasminogen activator, urokinase
PLCD1 phospholipase C, delta 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLK2 polo-like kinase 2
POLM polymerase (DNA directed), mu
POTEKP POTE ankyrin domain family, member K, pseudogene
POU5F1B POU class 5 homeobox 1B
PPARG peroxisome proliferator-activated receptor gamma
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRSS23 protease, serine, 23
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PTX3 pentraxin 3, long
RASAL1 RAS protein activator like 1 (GAP1 like)
RGS2 regulator of G-protein signaling 2
RNF141 ring finger protein 141
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
S100A1 S100 calcium binding protein A1
SCN1B sodium channel, voltage gated, type I beta subunit
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SPAG16 sperm associated antigen 16
TET3 tet methylcytosine dioxygenase 3
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia)
THOC1 THO complex 1
TMED1 transmembrane emp24 protein transport domain containing 1
TMEM127 transmembrane protein 127
TOE1 target of EGR1, member 1 (nuclear)
TRAPPC11 trafficking protein particle complex 11
TSLIG2 tRNA splicing ligase complex subunit 2
VIPR1 vasoactive intestinal peptide receptor 1
VNN3 vanin 3
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae)
XPA xeroderma pigmentosum, complementation group A
ZNF324 zinc finger protein 324
ZNF696 zinc finger protein 696