troglitazone-5229 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the troglitazone-5229 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT11 acyl-CoA thioesterase 11
ACPP acid phosphatase, prostate
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ALCAM activated leukocyte cell adhesion molecule
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGAP33 Rho GTPase activating protein 33
ARTN artemin
ASB1 ankyrin repeat and SOCS box containing 1
ASPH aspartate beta-hydroxylase
ATP10B ATPase, class V, type 10B
AUTS2 autism susceptibility candidate 2
BCAM basal cell adhesion molecule (Lutheran blood group)
BMP1 bone morphogenetic protein 1
C3ORF18 chromosome 3 open reading frame 18
CALCR calcitonin receptor
CCL27 chemokine (C-C motif) ligand 27
CCP110 centriolar coiled coil protein 110kDa
CD47 CD47 molecule
CD8A CD8a molecule
CLGN calmegin
CNPPD1 cyclin Pas1/PHO80 domain containing 1
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
CORO7 coronin 7
CPQ carboxypeptidase Q
CRYGC crystallin, gamma C
CST4 cystatin S
CUL7 cullin 7
CYLD cylindromatosis (turban tumor syndrome)
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DSTYK dual serine/threonine and tyrosine protein kinase
FBLN1 fibulin 1
FGFR1 fibroblast growth factor receptor 1
FOXI1 forkhead box I1
FSCN1 fascin actin-bundling protein 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAP43 growth associated protein 43
GRIK5 glutamate receptor, ionotropic, kainate 5
HIPK3 homeodomain interacting protein kinase 3
HLA-C major histocompatibility complex, class I, C
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
JRK Jrk homolog (mouse)
KDM8 lysine (K)-specific demethylase 8
KIAA1109 KIAA1109
LOC257152 uncharacterized LOC257152
LZTS3 leucine zipper, putative tumor suppressor family member 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MST1L macrophage stimulating 1-like
MXD4 MAX dimerization protein 4
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NCKIPSD NCK interacting protein with SH3 domain
NCOR2 nuclear receptor corepressor 2
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPM3 nucleophosmin/nucleoplasmin 3
PARPBP PARP1 binding protein
PBX2 pre-B-cell leukemia homeobox 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCD1 phospholipase C, delta 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POFUT1 protein O-fucosyltransferase 1
POLL polymerase (DNA directed), lambda
POU2F2 POU class 2 homeobox 2
PRF1 perforin 1 (pore forming protein)
PTPRS protein tyrosine phosphatase, receptor type, S
RAB11B RAB11B, member RAS oncogene family
RNF122 ring finger protein 122
RNF19B ring finger protein 19B
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SH3BP2 SH3-domain binding protein 2
SH3GL3 SH3-domain GRB2-like 3
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SNX13 sorting nexin 13
SOD2 superoxide dismutase 2, mitochondrial
SORT1 sortilin 1
SOS2 son of sevenless homolog 2 (Drosophila)
STK17A serine/threonine kinase 17a
SUGP1 SURP and G patch domain containing 1
TBC1D19 TBC1 domain family, member 19
TCP11L1 t-complex 11, testis-specific-like 1
TMPRSS2 transmembrane protease, serine 2
TPK1 thiamin pyrophosphokinase 1
TRAK1 trafficking protein, kinesin binding 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TTC38 tetratricopeptide repeat domain 38
TUBA4B tubulin, alpha 4b
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WNT6 wingless-type MMTV integration site family, member 6
ZNF204P zinc finger protein 204, pseudogene
ZNF492 zinc finger protein 492
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ACTL8 actin-like 8
APOD apolipoprotein D
ARPIN actin-related protein 2/3 complex inhibitor
ARRB1 arrestin, beta 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BLNK B-cell linker
BMP4 bone morphogenetic protein 4
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C11ORF63 chromosome 11 open reading frame 63
C7ORF43 chromosome 7 open reading frame 43
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCNT1 cyclin T1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPO centromere protein O
CEP85 centrosomal protein 85kDa
CLDN15 claudin 15
CTAGE9 CTAGE family, member 9
DDIT3 DNA-damage-inducible transcript 3
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
EFNA3 ephrin-A3
ENO2 enolase 2 (gamma, neuronal)
ERCC5 excision repair cross-complementation group 5
EXO5 exonuclease 5
FAM184A family with sequence similarity 184, member A
FBXL6 F-box and leucine-rich repeat protein 6
FLCN folliculin
FSD1 fibronectin type III and SPRY domain containing 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GALK1 galactokinase 1
GLRA1 glycine receptor, alpha 1
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRPR gastrin-releasing peptide receptor
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H2AI histone cluster 1, H2ai
HIST1H2AJ histone cluster 1, H2aj
HIST1H3G histone cluster 1, H3g
HYI hydroxypyruvate isomerase (putative)
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGSF1 immunoglobulin superfamily, member 1
IL4R interleukin 4 receptor
INCENP inner centromere protein antigens 135/155kDa
KCTD7 potassium channel tetramerization domain containing 7
KPTN kaptin (actin binding protein)
LAMP3 lysosomal-associated membrane protein 3
LY6D lymphocyte antigen 6 complex, locus D
LY6G6C lymphocyte antigen 6 complex, locus G6C
LYPLA2P1 lysophospholipase II pseudogene 1
MAGEH1 melanoma antigen family H1
MITF microphthalmia-associated transcription factor
NPIPB15 nuclear pore complex interacting protein family, member B15
NRSN2 neurensin 2
PCBP4 poly(rC) binding protein 4
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLA2G10 phospholipase A2, group X
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POMT1 protein-O-mannosyltransferase 1
POMT2 protein-O-mannosyltransferase 2
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
REEP1 receptor accessory protein 1
RGS19 regulator of G-protein signaling 19
RIBC2 RIB43A domain with coiled-coils 2
RIN1 Ras and Rab interactor 1
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEPP1 selenoprotein P, plasma, 1
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SLC22A14 solute carrier family 22, member 14
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC41A3 solute carrier family 41, member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLIT2 slit homolog 2 (Drosophila)
SLMO1 slowmo homolog 1 (Drosophila)
SUN2 Sad1 and UNC84 domain containing 2
SYBU syntabulin (syntaxin-interacting)
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TDRKH tudor and KH domain containing
TMEM104 transmembrane protein 104
TMEM121 transmembrane protein 121
TMEM180 transmembrane protein 180
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TTLL1 tubulin tyrosine ligase-like family member 1
USP19 ubiquitin specific peptidase 19
VAX2 ventral anterior homeobox 2
VGF VGF nerve growth factor inducible
VWA1 von Willebrand factor A domain containing 1
WDR25 WD repeat domain 25
ZNF668 zinc finger protein 668
ZNF747 zinc finger protein 747