troglitazone-6991 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the troglitazone-6991 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AMACR alpha-methylacyl-CoA racemase
ANGEL2 angel homolog 2 (Drosophila)
ANKMY1 ankyrin repeat and MYND domain containing 1
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGAP33 Rho GTPase activating protein 33
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARL3 ADP-ribosylation factor-like 3
BTF3P11 basic transcription factor 3 pseudogene 11
C14ORF79 chromosome 14 open reading frame 79
C1ORF61 chromosome 1 open reading frame 61
C2ORF54 chromosome 2 open reading frame 54
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CCL27 chemokine (C-C motif) ligand 27
CDC25A cell division cycle 25A
CDKN2A cyclin-dependent kinase inhibitor 2A
CIDEB cell death-inducing DFFA-like effector b
COL4A5 collagen, type IV, alpha 5
CYLD cylindromatosis (turban tumor syndrome)
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DUSP9 dual specificity phosphatase 9
EDDM3A epididymal protein 3A
EGR1 early growth response 1
ELOVL4 ELOVL fatty acid elongase 4
EML3 echinoderm microtubule associated protein like 3
ESR1 estrogen receptor 1
ESRRA estrogen-related receptor alpha
FAM204A family with sequence similarity 204, member A
FBXL2 F-box and leucine-rich repeat protein 2
FGFR4 fibroblast growth factor receptor 4
FLJ11292
FLT4 fms-related tyrosine kinase 4
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GSTA3 glutathione S-transferase alpha 3
GSTA4 glutathione S-transferase alpha 4
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HEXA hexosaminidase A (alpha polypeptide)
HIST1H3B histone cluster 1, H3b
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDI2-AS1 IDI2 antisense RNA 1
IFT22 intraflagellar transport 22
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IPO8 importin 8
ITGB4 integrin, beta 4
JADE2 jade family PHD finger 2
JUN jun proto-oncogene
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KIAA0368 KIAA0368
KIAA1109 KIAA1109
LMNA lamin A/C
LSP1 lymphocyte-specific protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK8 mitogen-activated protein kinase 8
MAPT microtubule-associated protein tau
MED12 mediator complex subunit 12
MED25 mediator complex subunit 25
MSN moesin
NDOR1 NADPH dependent diflavin oxidoreductase 1
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
OCA2 oculocutaneous albinism II
PAQR6 progestin and adipoQ receptor family member VI
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDE12 phosphodiesterase 12
PHTF2 putative homeodomain transcription factor 2
PROL1 proline rich, lacrimal 1
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RAB11B RAB11B, member RAS oncogene family
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RGS12 regulator of G-protein signaling 12
RPL23AP32 ribosomal protein L23a pseudogene 32
SAP30 Sin3A-associated protein, 30kDa
SCAND2P SCAN domain containing 2 pseudogene
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SGSM2 small G protein signaling modulator 2
SH3BP2 SH3-domain binding protein 2
SIX1 SIX homeobox 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SNRK SNF related kinase
SOCS1 suppressor of cytokine signaling 1
SORT1 sortilin 1
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SRPX sushi-repeat containing protein, X-linked
STAG3L1 stromal antigen 3-like 1 (pseudogene)
TMEM212 transmembrane protein 212
TPM1 tropomyosin 1 (alpha)
TRAFD1 TRAF-type zinc finger domain containing 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
WDR1 WD repeat domain 1
WDR59 WD repeat domain 59
WNT1 wingless-type MMTV integration site family, member 1

decreased expression

Symbol Name
ADAP2 ArfGAP with dual PH domains 2
ANKRD36 ankyrin repeat domain 36
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ATAD2B ATPase family, AAA domain containing 2B
ATAD3A ATPase family, AAA domain containing 3A
ATAD5 ATPase family, AAA domain containing 5
ATXN2 ataxin 2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BCOR BCL6 corepressor
C5ORF28 chromosome 5 open reading frame 28
C5ORF45 chromosome 5 open reading frame 45
CA11 carbonic anhydrase XI
CAPN15 calpain 15
CBX7 chromobox homolog 7
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD3EAP CD3e molecule, epsilon associated protein
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CEP85 centrosomal protein 85kDa
CEP97 centrosomal protein 97kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDND1 claudin domain containing 1
CRABP1 cellular retinoic acid binding protein 1
CSRNP2 cysteine-serine-rich nuclear protein 2
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DCAF17 DDB1 and CUL4 associated factor 17
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FAM57A family with sequence similarity 57, member A
FBXO22 F-box protein 22
FKBP10 FK506 binding protein 10, 65 kDa
FZD4 frizzled class receptor 4
GALK1 galactokinase 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GBAS glioblastoma amplified sequence
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
HAUS6 HAUS augmin-like complex, subunit 6
HIST1H2AJ histone cluster 1, H2aj
IFT140 intraflagellar transport 140
IFT88 intraflagellar transport 88
JMJD4 jumonji domain containing 4
KLF3 Kruppel-like factor 3 (basic)
KLHL21 kelch-like family member 21
LINS lines homolog (Drosophila)
LOC257152 uncharacterized LOC257152
LRRC61 leucine rich repeat containing 61
LY6D lymphocyte antigen 6 complex, locus D
MED22 mediator complex subunit 22
NBEAL2 neurobeachin-like 2
NCAM2 neural cell adhesion molecule 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OTUD3 OTU deubiquitinase 3
PBLD phenazine biosynthesis-like protein domain containing
PCSK7 proprotein convertase subtilisin/kexin type 7
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G15 phospholipase A2, group XV
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLD3 phospholipase D family, member 3
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PPT2 palmitoyl-protein thioesterase 2
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PTGES2 prostaglandin E synthase 2
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RAB3D RAB3D, member RAS oncogene family
RAB5B RAB5B, member RAS oncogene family
RBL1 retinoblastoma-like 1
RECQL4 RecQ protein-like 4
RNF31 ring finger protein 31
SETD1B SET domain containing 1B
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A40 solute carrier family 25, member 40
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOX12 SRY (sex determining region Y)-box 12
SP1 Sp1 transcription factor
SUSD6 sushi domain containing 6
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TCTN2 tectonic family member 2
TRAF2 TNF receptor-associated factor 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
UNC119 unc-119 homolog (C. elegans)
UNKL unkempt family zinc finger-like
USP20 ubiquitin specific peptidase 20
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WDR62 WD repeat domain 62
WDR91 WD repeat domain 91
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZFAND3 zinc finger, AN1-type domain 3
ZMYM3 zinc finger, MYM-type 3
ZNF211 zinc finger protein 211
ZNF324 zinc finger protein 324
ZNF668 zinc finger protein 668
ZNF675 zinc finger protein 675
ZNF778 zinc finger protein 778