troleandomycin-1885 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the troleandomycin-1885 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ACAN aggrecan
AK1 adenylate kinase 1
ANKRD12 ankyrin repeat domain 12
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASCL1 achaete-scute family bHLH transcription factor 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
AXIN1 axin 1
BCORL1 BCL6 corepressor-like 1
BICD1 bicaudal D homolog 1 (Drosophila)
CCPG1 cell cycle progression 1
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DTNA dystrobrevin, alpha
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGLN2 egl-9 family hypoxia-inducible factor 2
ESRRA estrogen-related receptor alpha
EVI5 ecotropic viral integration site 5
FMOD fibromodulin
GAR1 GAR1 ribonucleoprotein
GIMAP5 GTPase, IMAP family member 5
GOSR2 golgi SNAP receptor complex member 2
GPR1 G protein-coupled receptor 1
GRM4 glutamate receptor, metabotropic 4
HAMP hepcidin antimicrobial peptide
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICA1 islet cell autoantigen 1, 69kDa
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2RG interleukin 2 receptor, gamma
KLHL3 kelch-like family member 3
KPNB1 karyopherin (importin) beta 1
KPTN kaptin (actin binding protein)
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast)
MAP2K3 mitogen-activated protein kinase kinase 3
MARK3 MAP/microtubule affinity-regulating kinase 3
MMP7 matrix metallopeptidase 7
MTF1 metal-regulatory transcription factor 1
MUC2 mucin 2, oligomeric mucus/gel-forming
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NBL1 neuroblastoma 1, DAN family BMP antagonist
NELL2 NEL-like 2 (chicken)
NKIRAS2 NFKB inhibitor interacting Ras-like 2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NXPE3 neurexophilin and PC-esterase domain family, member 3
PADI2 peptidyl arginine deiminase, type II
PEX14 peroxisomal biogenesis factor 14
PLD2 phospholipase D2
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PROL1 proline rich, lacrimal 1
PTPRF protein tyrosine phosphatase, receptor type, F
RBM48 RNA binding motif protein 48
RBMS1 RNA binding motif, single stranded interacting protein 1
RECQL5 RecQ protein-like 5
REPIN1 replication initiator 1
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPL23AP32 ribosomal protein L23a pseudogene 32
RPL23AP7 ribosomal protein L23a pseudogene 7
SAA4 serum amyloid A4, constitutive
SFTPB surfactant protein B
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC22A14 solute carrier family 22, member 14
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
ST20 suppressor of tumorigenicity 20
ST5 suppression of tumorigenicity 5
TCP11L1 t-complex 11, testis-specific-like 1
TGFB3 transforming growth factor, beta 3
THTPA thiamine triphosphatase
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TPT1 tumor protein, translationally-controlled 1
TRIM45 tripartite motif containing 45
TSPAN12 tetraspanin 12
TSPAN15 tetraspanin 15
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBOX5 U-box domain containing 5
URI1 URI1, prefoldin-like chaperone
USP34 ubiquitin specific peptidase 34
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WNT5A wingless-type MMTV integration site family, member 5A
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
YIPF4 Yip1 domain family, member 4
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ADAT1 adenosine deaminase, tRNA-specific 1
ADGRG6 adhesion G protein-coupled receptor G6
ADM2 adrenomedullin 2
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APLP1 amyloid beta (A4) precursor-like protein 1
ARMC6 armadillo repeat containing 6
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BACE2 beta-site APP-cleaving enzyme 2
BCAP31 B-cell receptor-associated protein 31
BYSL bystin-like
C1ORF115 chromosome 1 open reading frame 115
C21ORF91 chromosome 21 open reading frame 91
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CD151 CD151 molecule (Raph blood group)
CDC123 cell division cycle 123
CEP85 centrosomal protein 85kDa
CEPT1 choline/ethanolamine phosphotransferase 1
CHML choroideremia-like (Rab escort protein 2)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLDND1 claudin domain containing 1
CLK2 CDC-like kinase 2
COMMD10 COMM domain containing 10
COMMD8 COMM domain containing 8
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYB5R4 cytochrome b5 reductase 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
DESI1 desumoylating isopeptidase 1
DGKD diacylglycerol kinase, delta 130kDa
EHD3 EH-domain containing 3
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ERCC3 excision repair cross-complementation group 3
FAM46A family with sequence similarity 46, member A
FEM1C fem-1 homolog c (C. elegans)
FOXA1 forkhead box A1
FXN frataxin
GAMT guanidinoacetate N-methyltransferase
GLOD4 glyoxalase domain containing 4
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
HELZ helicase with zinc finger
HMGB3P1 high mobility group box 3 pseudogene 1
HRSP12 heat-responsive protein 12
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGFBP6 insulin-like growth factor binding protein 6
ISYNA1 inositol-3-phosphate synthase 1
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
KDM1A lysine (K)-specific demethylase 1A
KIF18A kinesin family member 18A
KNTC1 kinetochore associated 1
KRT86 keratin 86, type II
MAD2L1BP MAD2L1 binding protein
MAL mal, T-cell differentiation protein
MAPK3 mitogen-activated protein kinase 3
MDN1 MDN1, midasin homolog (yeast)
MECR mitochondrial trans-2-enoyl-CoA reductase
MNS1 meiosis-specific nuclear structural 1
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MRPL16 mitochondrial ribosomal protein L16
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NFS1 NFS1 cysteine desulfurase
NINJ1 ninjurin 1
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NUP93 nucleoporin 93kDa
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
P3H1 prolyl 3-hydroxylase 1
PFDN1 prefoldin subunit 1
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PSKH1 protein serine kinase H1
RBM4B RNA binding motif protein 4B
RRP1 ribosomal RNA processing 1
RSAD1 radical S-adenosyl methionine domain containing 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC35E3 solute carrier family 35, member E3
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC39A7 solute carrier family 39 (zinc transporter), member 7
STARD13 StAR-related lipid transfer (START) domain containing 13
STAU2 staufen double-stranded RNA binding protein 2
STRA13 stimulated by retinoic acid 13
SURF2 surfeit 2
TACC3 transforming, acidic coiled-coil containing protein 3
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TBPL1 TBP-like 1
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TMEM184C transmembrane protein 184C
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TTLL12 tubulin tyrosine ligase-like family member 12
TWSG1 twisted gastrulation BMP signaling modulator 1
UCKL1 uridine-cytidine kinase 1-like 1
USP36 ubiquitin specific peptidase 36
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR13 WD repeat domain 13
ZDHHC6 zinc finger, DHHC-type containing 6
ZNF189 zinc finger protein 189