troleandomycin-3985 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the troleandomycin-3985 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADAM28 ADAM metallopeptidase domain 28
AKAP5 A kinase (PRKA) anchor protein 5
AKR1C4 aldo-keto reductase family 1, member C4
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATF5 activating transcription factor 5
ATF6B activating transcription factor 6 beta
ATXN7L1 ataxin 7-like 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
C2ORF72 chromosome 2 open reading frame 72
C9ORF9 chromosome 9 open reading frame 9
CA5B carbonic anhydrase VB, mitochondrial
CADM3 cell adhesion molecule 3
CALB2 calbindin 2
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CD33 CD33 molecule
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEP41 centrosomal protein 41kDa
CIC capicua transcriptional repressor
CLSTN3 calsyntenin 3
CNTFR ciliary neurotrophic factor receptor
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CST1 cystatin SN
CTSS cathepsin S
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DHRS12 dehydrogenase/reductase (SDR family) member 12
DIAPH2-AS1 DIAPH2 antisense RNA 1
DOK5 docking protein 5
DPP4 dipeptidyl-peptidase 4
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
EGR1 early growth response 1
ETNK2 ethanolamine kinase 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FN1 fibronectin 1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GHRHR growth hormone releasing hormone receptor
GP6 glycoprotein VI (platelet)
GPR68 G protein-coupled receptor 68
GSK3A glycogen synthase kinase 3 alpha
HABP4 hyaluronan binding protein 4
HIPK3 homeodomain interacting protein kinase 3
HIRA histone cell cycle regulator
HOXD10 homeobox D10
HRASLS2 HRAS-like suppressor 2
HSF1 heat shock transcription factor 1
ICOSLG inducible T-cell co-stimulator ligand
IHH indian hedgehog
IL12A interleukin 12A
IL32 interleukin 32
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCTD14 potassium channel tetramerization domain containing 14
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF13 Kruppel-like factor 13
LGALS8 lectin, galactoside-binding, soluble, 8
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LUM lumican
MAGEA12 melanoma antigen family A12
MAGEA5 melanoma antigen family A5
MEFV Mediterranean fever
MNDA myeloid cell nuclear differentiation antigen
MOBP myelin-associated oligodendrocyte basic protein
MYBPC3 myosin binding protein C, cardiac
MYO1A myosin IA
NLRP3 NLR family, pyrin domain containing 3
NPR1 natriuretic peptide receptor 1
NRF1 nuclear respiratory factor 1
NRXN3 neurexin 3
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OAZ3 ornithine decarboxylase antizyme 3
PDE10A phosphodiesterase 10A
PECAM1 platelet/endothelial cell adhesion molecule 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLCD1 phospholipase C, delta 1
PLD1 phospholipase D1, phosphatidylcholine-specific
PLXNA2 plexin A2
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RFPL2 ret finger protein-like 2
RHCE Rh blood group, CcEe antigens
SGSM3 small G protein signaling modulator 3
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLFN12 schlafen family member 12
SMAD4 SMAD family member 4
SRPX2 sushi-repeat containing protein, X-linked 2
SRSF7 serine/arginine-rich splicing factor 7
SULF1 sulfatase 1
TBRG4 transforming growth factor beta regulator 4
TLX2 T-cell leukemia homeobox 2
TLX3 T-cell leukemia homeobox 3
USP20 ubiquitin specific peptidase 20
ZNF287 zinc finger protein 287
ZNF334 zinc finger protein 334
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
AXIN1 axin 1
BDKRB1 bradykinin receptor B1
BFSP1 beaded filament structural protein 1, filensin
C5ORF42 chromosome 5 open reading frame 42
C5ORF45 chromosome 5 open reading frame 45
CBX8 chromobox homolog 8
CD68 CD68 molecule
CDIP1 cell death-inducing p53 target 1
CHRM3 cholinergic receptor, muscarinic 3
CIDEB cell death-inducing DFFA-like effector b
CLIP4 CAP-GLY domain containing linker protein family, member 4
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNGB3 cyclic nucleotide gated channel beta 3
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CRYBA2 crystallin, beta A2
DDN dendrin
DNAH7 dynein, axonemal, heavy chain 7
DNM3 dynamin 3
EFNB1 ephrin-B1
EHD3 EH-domain containing 3
FAM53B family with sequence similarity 53, member B
FBXL15 F-box and leucine-rich repeat protein 15
FKBP1B FK506 binding protein 1B, 12.6 kDa
GJA9 gap junction protein, alpha 9, 59kDa
GMEB1 glucocorticoid modulatory element binding protein 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPATCH2L G patch domain containing 2-like
GRM4 glutamate receptor, metabotropic 4
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HDAC7 histone deacetylase 7
HIST2H2AA3 histone cluster 2, H2aa3
IRAK4 interleukin-1 receptor-associated kinase 4
KCTD20 potassium channel tetramerization domain containing 20
KIAA0754 KIAA0754
KIAA1456 KIAA1456
KRT86 keratin 86, type II
LIN7B lin-7 homolog B (C. elegans)
LMO2 LIM domain only 2 (rhombotin-like 1)
LNPEP leucyl/cystinyl aminopeptidase
MAPK12 mitogen-activated protein kinase 12
MAST3 microtubule associated serine/threonine kinase 3
MCTP2 multiple C2 domains, transmembrane 2
MFGE8 milk fat globule-EGF factor 8 protein
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MN1 meningioma (disrupted in balanced translocation) 1
MNMIP1 manchette microtubule inner protein 1
MUM1 melanoma associated antigen (mutated) 1
MYL5 myosin, light chain 5, regulatory
MYO1F myosin IF
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NBEAL2 neurobeachin-like 2
NKX3-2 NK3 homeobox 2
NLGN1 neuroligin 1
NTSR1 neurotensin receptor 1 (high affinity)
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
ONECUT2 one cut homeobox 2
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PARD6A par-6 family cell polarity regulator alpha
PHC1 polyhomeotic homolog 1 (Drosophila)
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLAG1 pleiomorphic adenoma gene 1
PLD3 phospholipase D family, member 3
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POMT2 protein-O-mannosyltransferase 2
PPL periplakin
PRR4 proline rich 4 (lacrimal)
PRSS53 protease, serine, 53
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RUNX1-IT1 RUNX1 intronic transcript 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SAYSD1 SAYSVFN motif domain containing 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SH3GLB2 SH3-domain GRB2-like endophilin B2
SLAMF7 SLAM family member 7
SLC16A6 solute carrier family 16, member 6
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SSTR4 somatostatin receptor 4
STAG3 stromal antigen 3
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TESPA1 thymocyte expressed, positive selection associated 1
TH tyrosine hydroxylase
TINAGL1 tubulointerstitial nephritis antigen-like 1
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TSKU tsukushi, small leucine rich proteoglycan
TTLL1 tubulin tyrosine ligase-like family member 1
TUBA3C tubulin, alpha 3c
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
WDR33 WD repeat domain 33
ZNF268 zinc finger protein 268
ZNF358 zinc finger protein 358
ZNF528 zinc finger protein 528
ZSCAN31 zinc finger and SCAN domain containing 31