tropine-6147 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the tropine-6147 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
AAK1 AP2 associated kinase 1
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ACVR1B activin A receptor, type IB
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKT2 v-akt murine thymoma viral oncogene homolog 2
AMPH amphiphysin
AREG amphiregulin
ARHGAP44 Rho GTPase activating protein 44
ARR3 arrestin 3, retinal (X-arrestin)
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BIN1 bridging integrator 1
C1ORF61 chromosome 1 open reading frame 61
CA11 carbonic anhydrase XI
CA5B carbonic anhydrase VB, mitochondrial
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCDC132 coiled-coil domain containing 132
CCNK cyclin K
CD47 CD47 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CLIP4 CAP-GLY domain containing linker protein family, member 4
CLTA clathrin, light chain A
COL14A1 collagen, type XIV, alpha 1
CRTAC1 cartilage acidic protein 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTTN cortactin
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DPYSL3 dihydropyrimidinase-like 3
EDN3 endothelin 3
EMP1 epithelial membrane protein 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
ESR1 estrogen receptor 1
F2RL3 coagulation factor II (thrombin) receptor-like 3
FBXO2 F-box protein 2
FOXP3 forkhead box P3
FRMD1 FERM domain containing 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GJA4 gap junction protein, alpha 4, 37kDa
GPR1 G protein-coupled receptor 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIPK3 homeodomain interacting protein kinase 3
HMHB1 histocompatibility (minor) HB-1
KCNIP1 Kv channel interacting protein 1
KIF5C kinesin family member 5C
KLK3 kallikrein-related peptidase 3
KLRAP1 killer cell lectin-like receptor subfamily A pseudogene 1
KRT31 keratin 31, type I
LIMS2 LIM and senescent cell antigen-like domains 2
LUZP4 leucine zipper protein 4
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MECOM MDS1 and EVI1 complex locus
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MINK1 misshapen-like kinase 1
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MOB3B MOB kinase activator 3B
NR6A1 nuclear receptor subfamily 6, group A, member 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP88 nucleoporin 88kDa
OLFML2A olfactomedin-like 2A
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PDE4DIP phosphodiesterase 4D interacting protein
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM5 PDZ and LIM domain 5
PIGR polymeric immunoglobulin receptor
PSG11 pregnancy specific beta-1-glycoprotein 11
PVR poliovirus receptor
PXDC1 PX domain containing 1
PYY peptide YY
RBFA ribosome binding factor A (putative)
RERE arginine-glutamic acid dipeptide (RE) repeats
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RIMS2 regulating synaptic membrane exocytosis 2
RTCA RNA 3'-terminal phosphate cyclase
RUNDC3A RUN domain containing 3A
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SFRP4 secreted frizzled-related protein 4
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SMYD2 SET and MYND domain containing 2
SP1 Sp1 transcription factor
ST7L suppression of tumorigenicity 7 like
STARD5 StAR-related lipid transfer (START) domain containing 5
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCF4 transcription factor 4
TIMELESS timeless circadian clock
TTC38 tetratricopeptide repeat domain 38
TYRO3 TYRO3 protein tyrosine kinase
VEGFA vascular endothelial growth factor A
VPS9D1 VPS9 domain containing 1
WSCD1 WSC domain containing 1
ZER1 zyg-11 related, cell cycle regulator
ZMYND11 zinc finger, MYND-type containing 11
ZNF484 zinc finger protein 484
ZNF507 zinc finger protein 507

decreased expression

Symbol Name
AKTIP AKT interacting protein
ALS2CL ALS2 C-terminal like
AMT aminomethyltransferase
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
AQP9 aquaporin 9
ARMC4 armadillo repeat containing 4
BSPRY B-box and SPRY domain containing
C3ORF18 chromosome 3 open reading frame 18
C7ORF69 chromosome 7 open reading frame 69
C9ORF9 chromosome 9 open reading frame 9
CBX4 chromobox homolog 4
CCDC134 coiled-coil domain containing 134
CEP72 centrosomal protein 72kDa
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CORT cortistatin
CPVL carboxypeptidase, vitellogenic-like
CRABP2 cellular retinoic acid binding protein 2
CRMP1 collapsin response mediator protein 1
CTRL chymotrypsin-like
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNMBP dynamin binding protein
DUSP8 dual specificity phosphatase 8
EXD3 exonuclease 3'-5' domain containing 3
FBXL6 F-box and leucine-rich repeat protein 6
FRS3 fibroblast growth factor receptor substrate 3
GAA glucosidase, alpha; acid
GADD45G growth arrest and DNA-damage-inducible, gamma
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GJA8 gap junction protein, alpha 8, 50kDa
GPC3 glypican 3
GSPT2 G1 to S phase transition 2
HCAR3 hydroxycarboxylic acid receptor 3
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
IDI2-AS1 IDI2 antisense RNA 1
IFNA14 interferon, alpha 14
IFNA17 interferon, alpha 17
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL24 interleukin 24
INA internexin neuronal intermediate filament protein, alpha
INHBE inhibin, beta E
INO80D INO80 complex subunit D
IQCC IQ motif containing C
ITPKC inositol-trisphosphate 3-kinase C
KCNK5 potassium channel, two pore domain subfamily K, member 5
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LIME1 Lck interacting transmembrane adaptor 1
LOC157562 uncharacterized LOC157562
LOC729164 hCG1732469
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MVD mevalonate (diphospho) decarboxylase
MXD3 MAX dimerization protein 3
NELL2 NEL-like 2 (chicken)
NOD2 nucleotide-binding oligomerization domain containing 2
OMG oligodendrocyte myelin glycoprotein
OR1G1 olfactory receptor, family 1, subfamily G, member 1
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PCOLCE2 procollagen C-endopeptidase enhancer 2
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PODNL1 podocan-like 1
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PRKCZ protein kinase C, zeta
PYGB phosphorylase, glycogen; brain
RAB33A RAB33A, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF126P1 ring finger protein 126 pseudogene 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPL23AP32 ribosomal protein L23a pseudogene 32
S100A12 S100 calcium binding protein A12
SCUBE3 signal peptide, CUB domain, EGF-like 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLITRK5 SLIT and NTRK-like family, member 5
SMR3A submaxillary gland androgen regulated protein 3A
SSBP3 single stranded DNA binding protein 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TAS2R10 taste receptor, type 2, member 10
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TP53I3 tumor protein p53 inducible protein 3
TRIM36 tripartite motif containing 36
TSPAN13 tetraspanin 13
TTC33 tetratricopeptide repeat domain 33
TUBB2A tubulin, beta 2A class IIa
VANGL1 VANGL planar cell polarity protein 1
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
WDR62 WD repeat domain 62
WDR91 WD repeat domain 91
WFDC2 WAP four-disulfide core domain 2
XKR8 XK, Kell blood group complex subunit-related family, member 8
XPA xeroderma pigmentosum, complementation group A
XYLT2 xylosyltransferase II
ZBTB22 zinc finger and BTB domain containing 22
ZIC3 Zic family member 3
ZNF862 zinc finger protein 862