tslp Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description thymic stromal lymphopoietin|This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012] (NCBI Entrez Gene Database, 85480)
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Genes

44 genes co-occuring with the biological term tslp in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CD34 CD34 molecule
CD40LG CD40 ligand
CRLF2 cytokine receptor-like factor 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
F2RL1 coagulation factor II (thrombin) receptor-like 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FLG filaggrin
FOXP3 forkhead box P3
IL12A interleukin 12A
IL12RB1 interleukin 12 receptor, beta 1
IL13 interleukin 13
IL1A interleukin 1, alpha
IL23A interleukin 23, alpha subunit p19
IL33 interleukin 33
IL33R interleukin 33 receptor
IL4 interleukin 4
IL4R interleukin 4 receptor
IL7 interleukin 7
IL9 interleukin 9
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JUN jun proto-oncogene
KLK11 kallikrein-related peptidase 11
MUC5B mucin 5B, oligomeric mucus/gel-forming
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
PPARG peroxisome proliferator-activated receptor gamma
SPINK5 serine peptidase inhibitor, Kazal type 5
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TGFB1 transforming growth factor, beta 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLR3 toll-like receptor 3
TLR5 toll-like receptor 5
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSLP thymic stromal lymphopoietin
XBP1 X-box binding protein 1