tubocurarine chloride-5449 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the tubocurarine chloride-5449 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN2 actinin, alpha 2
ADAM22 ADAM metallopeptidase domain 22
AKT3 v-akt murine thymoma viral oncogene homolog 3
ATN1 atrophin 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BMP1 bone morphogenetic protein 1
C1ORF95 chromosome 1 open reading frame 95
C21ORF2 chromosome 21 open reading frame 2
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle)
CD47 CD47 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLSTN3 calsyntenin 3
CNN3 calponin 3, acidic
CNTNAP2 contactin associated protein-like 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL6A1 collagen, type VI, alpha 1
COMT catechol-O-methyltransferase
CPED1 cadherin-like and PC-esterase domain containing 1
DOPEY2 dopey family member 2
DPF3 D4, zinc and double PHD fingers, family 3
EPHA1 EPH receptor A1
EWSR1 EWS RNA-binding protein 1
FAM46C family with sequence similarity 46, member C
FHL3 four and a half LIM domains 3
FSCN3 fascin actin-bundling protein 3, testicular
GHRHR growth hormone releasing hormone receptor
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPR161 G protein-coupled receptor 161
HSF1 heat shock transcription factor 1
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IFITM1 interferon induced transmembrane protein 1
IRF9 interferon regulatory factor 9
JMJD6 jumonji domain containing 6
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KIF13B kinesin family member 13B
KIF25 kinesin family member 25
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LAMA4 laminin, alpha 4
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LY75 lymphocyte antigen 75
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MARS methionyl-tRNA synthetase
MFSD7 major facilitator superfamily domain containing 7
MVB12B multivesicular body subunit 12B
MYO1B myosin IB
NDNF neuron-derived neurotrophic factor
NF1 neurofibromin 1
NRG1 neuregulin 1
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
PAIP2B poly(A) binding protein interacting protein 2B
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PBX2 pre-B-cell leukemia homeobox 2
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
POLM polymerase (DNA directed), mu
POPDC3 popeye domain containing 3
PPARD peroxisome proliferator-activated receptor delta
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRAMEF10 PRAME family member 10
PRB1 proline-rich protein BstNI subfamily 1
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PTCH2 patched 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAB2A RAB2A, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RELN reelin
RGS10 regulator of G-protein signaling 10
RPL35A ribosomal protein L35a
S100A2 S100 calcium binding protein A2
SHOX2 short stature homeobox 2
SOX2 SRY (sex determining region Y)-box 2
SPON1 spondin 1, extracellular matrix protein
SPRY4 sprouty homolog 4 (Drosophila)
SSTR4 somatostatin receptor 4
STAT2 signal transducer and activator of transcription 2, 113kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TIGD6 tigger transposable element derived 6
TLR1 toll-like receptor 1
TMEM144 transmembrane protein 144
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TSPAN9 tetraspanin 9
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCN urocortin
USP18 ubiquitin specific peptidase 18
WNK1 WNK lysine deficient protein kinase 1
WNT1 wingless-type MMTV integration site family, member 1
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF236 zinc finger protein 236

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACTL8 actin-like 8
APOD apolipoprotein D
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BTBD2 BTB (POZ) domain containing 2
C10ORF95 chromosome 10 open reading frame 95
C1QTNF3 C1q and tumor necrosis factor related protein 3
C8ORF60 chromosome 8 open reading frame 60
CAPN15 calpain 15
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CENPQ centromere protein Q
CGA glycoprotein hormones, alpha polypeptide
CHST10 carbohydrate sulfotransferase 10
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLSPN claspin
CTSF cathepsin F
DBF4B DBF4 zinc finger B
DMTN dematin actin binding protein
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSCAM Down syndrome cell adhesion molecule
ETNK2 ethanolamine kinase 2
FER fer (fps/fes related) tyrosine kinase
FGD1 FYVE, RhoGEF and PH domain containing 1
FLJ11710 uncharacterized protein FLJ11710
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GMPR guanosine monophosphate reductase
GPR27 G protein-coupled receptor 27
GPX2 glutathione peroxidase 2
GSTA4 glutathione S-transferase alpha 4
HIST1H1D histone cluster 1, H1d
HIST1H3E histone cluster 1, H3e
HIST1H4D histone cluster 1, H4d
HOXC10 homeobox C10
IGFBP6 insulin-like growth factor binding protein 6
INPP5J inositol polyphosphate-5-phosphatase J
KIAA0754 KIAA0754
KLF3 Kruppel-like factor 3 (basic)
KLK5 kallikrein-related peptidase 5
KPNA5 karyopherin alpha 5 (importin alpha 6)
LAMA3 laminin, alpha 3
LOC730101 uncharacterized LOC730101
LRRC37A3 leucine rich repeat containing 37, member A3
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MOSPD3 motile sperm domain containing 3
MRPL41 mitochondrial ribosomal protein L41
MRPS18C mitochondrial ribosomal protein S18C
N4BP3 NEDD4 binding protein 3
NOL12 nucleolar protein 12
PCSK7 proprotein convertase subtilisin/kexin type 7
PDE12 phosphodiesterase 12
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G3 phospholipase A2, group III
PLEKHO1 pleckstrin homology domain containing, family O member 1
POMT2 protein-O-mannosyltransferase 2
PRKCE protein kinase C, epsilon
PRSS22 protease, serine, 22
PTPRU protein tyrosine phosphatase, receptor type, U
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RFXAP regulatory factor X-associated protein
RIN1 Ras and Rab interactor 1
RPGR retinitis pigmentosa GTPase regulator
RPL10L ribosomal protein L10-like
RUSC2 RUN and SH3 domain containing 2
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMA4 glucuronidase, beta pseudogene
SPIDR scaffolding protein involved in DNA repair
SRD5A3 steroid 5 alpha-reductase 3
TEP1 telomerase-associated protein 1
TGFBR3 transforming growth factor, beta receptor III
THRAP3 thyroid hormone receptor associated protein 3
TMEM120B transmembrane protein 120B
TRIM36 tripartite motif containing 36
TSPYL2 TSPY-like 2
TUBA3C tubulin, alpha 3c
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBQLN4 ubiquilin 4
UNC119 unc-119 homolog (C. elegans)
VIPR1 vasoactive intestinal peptide receptor 1
WDR76 WD repeat domain 76
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZFP37 ZFP37 zinc finger protein
ZNF136 zinc finger protein 136
ZNF324 zinc finger protein 324
ZNF408 zinc finger protein 408
ZNF862 zinc finger protein 862