tyk2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description tyrosine kinase 2|This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7297)
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Genes

29 genes co-occuring with the biological term tyk2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
BCL2 B-cell CLL/lymphoma 2
IFIH1 interferon induced with helicase C domain 1
IFNA1 interferon, alpha 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL13 interleukin 13
IL17C interleukin 17C
IL2RG interleukin 2 receptor, gamma
IL7 interleukin 7
IRF5 interferon regulatory factor 5
IRF8 interferon regulatory factor 8
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
MPL MPL proto-oncogene, thrombopoietin receptor
NCF2 neutrophil cytosolic factor 2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PLAU plasminogen activator, urokinase
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RHOA ras homolog family member A
SIVA1 SIVA1, apoptosis-inducing factor
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TYK2 tyrosine kinase 2