tyr Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description tyrosinase|The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 7299)
Similar Terms
Downloads & Tools

Genes

79 genes co-occuring with the biological term tyr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACAT1 acetyl-CoA acetyltransferase 1
AGO2 argonaute RISC catalytic component 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ASIP agouti signaling protein
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BST2 bone marrow stromal cell antigen 2
CASP8 caspase 8, apoptosis-related cysteine peptidase
CBX5 chromobox homolog 5
CSF3R colony stimulating factor 3 receptor (granulocyte)
CXCR4 chemokine (C-X-C motif) receptor 4
CYBB cytochrome b-245, beta polypeptide
DCT dopachrome tautomerase
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EGFR epidermal growth factor receptor
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EXOC2 exocyst complex component 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FUS FUS RNA binding protein
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
G6PD glucose-6-phosphate dehydrogenase
GPR143 G protein-coupled receptor 143
H2AFX H2A histone family, member X
HCLS1 hematopoietic cell-specific Lyn substrate 1
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HFE hemochromatosis
HTN1 histatin 1
IAPP islet amyloid polypeptide
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INPPL1 inositol polyphosphate phosphatase-like 1
IRF4 interferon regulatory factor 4
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPT microtubule-associated protein tau
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MEN1 multiple endocrine neoplasia I
MIR330 microRNA 330
MITF microphthalmia-associated transcription factor
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
OAZ1 ornithine decarboxylase antizyme 1
OCA2 oculocutaneous albinism II
OCLN occludin
OTX2 orthodenticle homeobox 2
PDCD6IP programmed cell death 6 interacting protein
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2B protein tyrosine kinase 2 beta
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PYCARD PYD and CARD domain containing
RIPK2 receptor-interacting serine-threonine kinase 2
SIRT3 sirtuin 3
SLC45A2 solute carrier family 45, member 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SYK spleen tyrosine kinase
TJP1 tight junction protein 1
TLN1 talin 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TYR tyrosinase
TYRP1 tyrosinase-related protein 1
VCP valosin containing protein
VEGFA vascular endothelial growth factor A
WAS Wiskott-Aldrich syndrome