| Dataset | GO Molecular Function Annotations 2015 |
| Category | structural or functional annotations |
| Type | molecular function |
| Description | Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate. (Gene Ontology, GO_0004839) |
| External Link | http://amigo.geneontology.org/amigo/term/GO:0004839 |
| Similar Terms | |
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4 genes performing the ubiquitin activating enzyme activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.
