ubiquitin protein ligase activity Gene Set

Dataset GO Molecular Function Annotations 2025
Category structural or functional annotations
Type molecular function
Description Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S --> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate. Note that this may include the extension of ubiquitin chains. (Gene Ontology, GO_0061630)
External Link http://amigo.geneontology.org/amigo/term/GO:0061630
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Genes

314 genes performing the ubiquitin protein ligase activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

Symbol Name
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANAPC11 anaphase promoting complex subunit 11
ANKIB1 ankyrin repeat and IBR domain containing 1
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ARK2C arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C
ASB1 ankyrin repeat and SOCS box containing 1
ASB12 ankyrin repeat and SOCS box containing 12
ASB2 ankyrin repeat and SOCS box containing 2
BFAR bifunctional apoptosis regulator
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BIRC7 baculoviral IAP repeat containing 7
BSPRY B-box and SPRY domain containing
C10ORF90 chromosome 10 open reading frame 90
C18ORF25 chromosome 18 open reading frame 25
C6ORF89 chromosome 6 open reading frame 89
CARD16 caspase recruitment domain family, member 16
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
CBLL2 Cbl proto-oncogene like 2
CCAR1 cell division cycle and apoptosis regulator 1
CDC42 cell division cycle 42
CUL3 cullin 3
CUL4A cullin 4A
CUL9 cullin 9
DCST1 DC-STAMP domain containing 1
DTX1 deltex 1, E3 ubiquitin ligase
DTX2 deltex 2, E3 ubiquitin ligase
DTX3 deltex 3, E3 ubiquitin ligase
DTX3L deltex 3 like, E3 ubiquitin ligase
DTX4 deltex 4, E3 ubiquitin ligase
FANCL Fanconi anemia, complementation group L
FBXL22 F-box and leucine-rich repeat protein 22
FBXO17 F-box protein 17
FBXO2 F-box protein 2
FBXO27 F-box protein 27
FBXO44 F-box protein 44
FBXO6 F-box protein 6
GID4 GID complex subunit 4
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HLTF helicase-like transcription factor
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRF2BPL interferon regulatory factor 2 binding protein-like
ITCH itchy E3 ubiquitin protein ligase
KCMF1 potassium channel modulatory factor 1
LOC122513141 ring finger protein-like
LRSAM1 leucine rich repeat and sterile alpha motif containing 1
LTN1 listerin E3 ubiquitin protein ligase 1
MARCHF1 membrane associated ring-CH-type finger 1
MARCHF2 membrane associated ring-CH-type finger 2
MARCHF5 membrane associated ring-CH-type finger 5
MARCHF6 membrane associated ring-CH-type finger 6
MARCHF7 membrane associated ring-CH-type finger 7
MARCHF8 membrane associated ring-CH-type finger 8
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEFV Mediterranean fever
MEX3C mex-3 RNA binding family member C
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase
MIB1 mindbomb E3 ubiquitin protein ligase 1
MIB2 mindbomb E3 ubiquitin protein ligase 2
MKRN1 makorin ring finger protein 1
MKRN2 makorin ring finger protein 2
MKRN3 makorin ring finger protein 3
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MSL2 male-specific lethal 2 homolog (Drosophila)
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYLIP myosin regulatory light chain interacting protein
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEURL1 neuralized E3 ubiquitin protein ligase 1
NEURL1B neuralized E3 ubiquitin protein ligase 1B
NEURL2 neuralized E3 ubiquitin protein ligase 2
NEURL3 neuralized E3 ubiquitin protein ligase 3
NEURL4 neuralized E3 ubiquitin protein ligase 4
NFX1 nuclear transcription factor, X-box binding 1
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1
NHLRC3 NHL repeat containing 3
NSMCE1 non-SMC element 1 homolog (S. cerevisiae)
NT5C2 5'-nucleotidase, cytosolic II
PDZRN3 PDZ domain containing ring finger 3
PELI1 pellino E3 ubiquitin protein ligase 1
PELI2 pellino E3 ubiquitin protein ligase family member 2
PELI3 pellino E3 ubiquitin protein ligase family member 3
PEX10 peroxisomal biogenesis factor 10
PEX12 peroxisomal biogenesis factor 12
PEX2 peroxisomal biogenesis factor 2
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11
PRKN parkin RBR E3 ubiquitin protein ligase
PRPF19 pre-mRNA processing factor 19
RAG1 recombination activating gene 1
RBBP6 retinoblastoma binding protein 6
RBX1 ring-box 1, E3 ubiquitin protein ligase
RC3H1 ring finger and CCCH-type domains 1
RC3H2 ring finger and CCCH-type domains 2
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RFPL1 ret finger protein-like 1
RFPL2 ret finger protein-like 2
RFPL3 ret finger protein-like 3
RFPL4A ret finger protein-like 4A
RFPL4AL1 ret finger protein-like 4A-like 1
RFPL4B ret finger protein-like 4B
RFWD3 ring finger and WD repeat domain 3
RING1 ring finger protein 1
RLIM ring finger protein, LIM domain interacting
RNF10 ring finger protein 10
RNF103 ring finger protein 103
RNF11 ring finger protein 11
RNF111 ring finger protein 111
RNF112 ring finger protein 112
RNF113A ring finger protein 113A
RNF114 ring finger protein 114
RNF115 ring finger protein 115
RNF121 ring finger protein 121
RNF122 ring finger protein 122
RNF123 ring finger protein 123
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF126 ring finger protein 126
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF13 ring finger protein 13
RNF130 ring finger protein 130
RNF133 ring finger protein 133
RNF135 ring finger protein 135
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RNF139 ring finger protein 139
RNF14 ring finger protein 14
RNF144A ring finger protein 144A
RNF144B ring finger protein 144B
RNF145 ring finger protein 145
RNF146 ring finger protein 146
RNF148 ring finger protein 148
RNF149 ring finger protein 149
RNF150 ring finger protein 150
RNF152 ring finger protein 152
RNF157 ring finger protein 157
RNF166 ring finger protein 166
RNF167 ring finger protein 167
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF175 ring finger protein 175
RNF180 ring finger protein 180
RNF181 ring finger protein 181
RNF183 ring finger protein 183
RNF185 ring finger protein 185
RNF186 ring finger protein 186
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF19B ring finger protein 19B
RNF2 ring finger protein 2
RNF20 ring finger protein 20, E3 ubiquitin protein ligase
RNF208 ring finger protein 208
RNF212B ring finger protein 212B
RNF213 ring finger protein 213
RNF215 ring finger protein 215
RNF216 ring finger protein 216
RNF217 ring finger protein 217
RNF220 ring finger protein 220
RNF223 ring finger protein 223
RNF225 ring finger protein 225
RNF227 ring finger protein 227
RNF228 ring finger protein 228
RNF25 ring finger protein 25
RNF26 ring finger protein 26
RNF31 ring finger protein 31
RNF34 ring finger protein 34, E3 ubiquitin protein ligase
RNF38 ring finger protein 38
RNF39 ring finger protein 39
RNF4 ring finger protein 4
RNF40 ring finger protein 40, E3 ubiquitin protein ligase
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RNF43 ring finger protein 43
RNF44 ring finger protein 44
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RNF6 ring finger protein (C3H2C3 type) 6
RNF7 ring finger protein 7
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RNFT1 ring finger protein, transmembrane 1
RNFT2 ring finger protein, transmembrane 2
RPGR retinitis pigmentosa GTPase regulator
SH3RF1 SH3 domain containing ring finger 1
SH3RF2 SH3 domain containing ring finger 2
SH3RF3 SH3 domain containing ring finger 3
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase
SIAH1 siah E3 ubiquitin protein ligase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SIAH3 siah E3 ubiquitin protein ligase family member 3
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TANK TRAF family member-associated NFKB activator
TMEM129 transmembrane protein 129, E3 ubiquitin protein ligase
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRAF3 TNF receptor-associated factor 3
TRAF3IP2 TRAF3 interacting protein 2
TRAF5 TNF receptor-associated factor 5
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase
TRAIP TRAF interacting protein
TRIM10 tripartite motif containing 10
TRIM11 tripartite motif containing 11
TRIM13 tripartite motif containing 13
TRIM14 tripartite motif containing 14
TRIM15 tripartite motif containing 15
TRIM17 tripartite motif containing 17
TRIM2 tripartite motif containing 2
TRIM21 tripartite motif containing 21
TRIM22 tripartite motif containing 22
TRIM23 tripartite motif containing 23
TRIM24 tripartite motif containing 24
TRIM25 tripartite motif containing 25
TRIM26 tripartite motif containing 26
TRIM27 tripartite motif containing 27
TRIM28 tripartite motif containing 28
TRIM3 tripartite motif containing 3
TRIM31 tripartite motif containing 31
TRIM32 tripartite motif containing 32
TRIM35 tripartite motif containing 35
TRIM37 tripartite motif containing 37
TRIM38 tripartite motif containing 38
TRIM39 tripartite motif containing 39
TRIM4 tripartite motif containing 4
TRIM40 tripartite motif containing 40
TRIM41 tripartite motif containing 41
TRIM43 tripartite motif containing 43
TRIM43B tripartite motif containing 43B
TRIM44 tripartite motif containing 44
TRIM45 tripartite motif containing 45
TRIM47 tripartite motif containing 47
TRIM48 tripartite motif containing 48
TRIM49 tripartite motif containing 49
TRIM49B tripartite motif containing 49B
TRIM49C tripartite motif containing 49C
TRIM49D2 tripartite motif containing 49D2
TRIM5 tripartite motif containing 5
TRIM50 tripartite motif containing 50
TRIM51 tripartite motif-containing 51
TRIM51G tripartite motif-containing 51G
TRIM52 tripartite motif containing 52
TRIM54 tripartite motif containing 54
TRIM55 tripartite motif containing 55
TRIM56 tripartite motif containing 56
TRIM58 tripartite motif containing 58
TRIM59 tripartite motif containing 59
TRIM6-TRIM34 TRIM6-TRIM34 readthrough
TRIM60 tripartite motif containing 60
TRIM61 tripartite motif containing 61
TRIM62 tripartite motif containing 62
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase
TRIM64 tripartite motif containing 64
TRIM64B tripartite motif containing 64B
TRIM64C tripartite motif containing 64C
TRIM65 tripartite motif containing 65
TRIM68 tripartite motif containing 68
TRIM69 tripartite motif containing 69
TRIM7 tripartite motif containing 7
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase
TRIM73 tripartite motif containing 73
TRIM74 tripartite motif containing 74
TRIM75 tripartite motif containing 75
TRIM77 tripartite motif containing 77
TRIM8 tripartite motif containing 8
TRIM9 tripartite motif containing 9
TRIML1 tripartite motif family-like 1
TRIML2 tripartite motif family-like 2
TRIP12 thyroid hormone receptor interactor 12
UBE2C ubiquitin-conjugating enzyme E2C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2K ubiquitin-conjugating enzyme E2K
UBE2O ubiquitin-conjugating enzyme E2O
UBE3A ubiquitin protein ligase E3A
UBE3B ubiquitin protein ligase E3B
UBE3C ubiquitin protein ligase E3C
UBE3D ubiquitin protein ligase E3D
UBE4A ubiquitination factor E4A
UBE4B ubiquitination factor E4B
UBOX5 U-box domain containing 5
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UBR2 ubiquitin protein ligase E3 component n-recognin 2
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative)
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UHRF1 ubiquitin-like with PHD and ring finger domains 1
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae)
WDR24 WD repeat domain 24
WWP1 WW domain containing E3 ubiquitin protein ligase 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZNF598 zinc finger protein 598
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase
ZNRF3 zinc and ring finger 3
ZNRF4 zinc and ring finger 4