ubiquitin-dependent ERAD pathway Gene Set

Dataset GO Biological Process Annotations 2023
Category structural or functional annotations
Type biological process
Description The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. (Gene Ontology, GO_0030433)
External Link http://amigo.geneontology.org/amigo/term/GO_0030433
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Genes

74 genes participating in the ubiquitin-dependent ERAD pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

Symbol Name
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKZF1 ankyrin repeat and zinc finger domain containing 1
AUP1 ancient ubiquitous protein 1
BAG6 BCL2-associated athanogene 6
CALR calreticulin
CALR3 calreticulin 3
CANX calnexin
CLGN calmegin
DERL1 derlin 1
DERL2 derlin 2
DERL3 derlin 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
ECPAS Ecm29 proteasome adaptor and scaffold
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
ERLEC1 endoplasmic reticulum lectin 1
ERLIN1 ER lipid raft associated 1
ERLIN2 ER lipid raft associated 2
FAF1 Fas (TNFRSF6) associated factor 1
FAF2 Fas associated factor family member 2
FAM8A1 family with sequence similarity 8, member A1
FBXO17 F-box protein 17
FBXO2 F-box protein 2
FBXO27 F-box protein 27
FBXO44 F-box protein 44
FBXO6 F-box protein 6
FOXRED2 FAD-dependent oxidoreductase domain containing 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
JKAMP JNK1/MAPK8-associated membrane protein
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN1B1 mannosidase, alpha, class 1B, member 1
MARCHF6 membrane associated ring-CH-type finger 6
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
RHBDD2 rhomboid domain containing 2
RNF103 ring finger protein 103
RNF121 ring finger protein 121
RNF175 ring finger protein 175
RNF185 ring finger protein 185
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
SEC61B Sec61 beta subunit
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SELENOS selenoprotein S
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TMEM129 transmembrane protein 129, E3 ubiquitin protein ligase
TMEM67 transmembrane protein 67
TMUB1 transmembrane and ubiquitin-like domain containing 1
TMUB2 transmembrane and ubiquitin-like domain containing 2
TRIM13 tripartite motif containing 13
TRIM25 tripartite motif containing 25
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBE2J2 ubiquitin-conjugating enzyme E2, J2
UBE4A ubiquitination factor E4A
UBE4B ubiquitination factor E4B
UBQLN1 ubiquilin 1
UBQLN2 ubiquilin 2
UBXN10 UBX domain protein 10
UBXN4 UBX domain protein 4
UBXN8 UBX domain protein 8
UFD1 ubiquitin recognition factor in ER associated degradation 1
USP19 ubiquitin specific peptidase 19
VCP valosin containing protein
WFS1 Wolfram syndrome 1 (wolframin)
YOD1 YOD1 deubiquitinase