ubiquitin-ubiquitin ligase activity Gene Set
Dataset
GO Molecular Function Annotations 2025
Category
structural or functional annotations
Type
molecular function
Description
Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. (Gene Ontology , GO_0034450 )
External Link
http://amigo.geneontology.org/amigo/term/GO:0034450
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Genes
16 genes performing the ubiquitin-ubiquitin ligase activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.
Symbol
Name
AMFR
autocrine motility factor receptor, E3 ubiquitin protein ligase
ANAPC11
anaphase promoting complex subunit 11
HUWE1
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ITCH
itchy E3 ubiquitin protein ligase
PELI1
pellino E3 ubiquitin protein ligase 1
PELI2
pellino E3 ubiquitin protein ligase family member 2
PPIL2
peptidylprolyl isomerase (cyclophilin)-like 2
PRPF19
pre-mRNA processing factor 19
RBX1
ring-box 1, E3 ubiquitin protein ligase
STUB1
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TRAF6
TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UBE2K
ubiquitin-conjugating enzyme E2K
UBE4A
ubiquitination factor E4A
UBE4B
ubiquitination factor E4B
UBOX5
U-box domain containing 5
UBR5
ubiquitin protein ligase E3 component n-recognin 5
