ugt1a1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description UDP glucuronosyltransferase 1 family, polypeptide A1|This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 54658)
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Genes

39 genes co-occuring with the biological term ugt1a1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AHR aryl hydrocarbon receptor
CDK2 cyclin-dependent kinase 2
COMT catechol-O-methyltransferase
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
DPYD dihydropyrimidine dehydrogenase
ESR1 estrogen receptor 1
G6PD glucose-6-phosphate dehydrogenase
GSTA1 glutathione S-transferase alpha 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
IL10 interleukin 10
KEAP1 kelch-like ECH-associated protein 1
NCOA2 nuclear receptor coactivator 2
NFE2L2 nuclear factor, erythroid 2-like 2
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
TPMT thiopurine S-methyltransferase
UGT1A UDP glucuronosyltransferase 1 family, polypeptide A complex locus
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7