uhrf1 Gene Set

Dataset	GeneRIF Biological Term Annotations
Category	structural or functional annotations
Type	biological term
Description	ubiquitin-like with PHD and ring finger domains 1\|This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014] (NCBI Entrez Gene Database, 29128)
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Genes

17 genes co-occuring with the biological term uhrf1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol	Name
ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1
BRCA1	breast cancer 1, early onset
CD47	CD47 molecule
CDKN2A	cyclin-dependent kinase inhibitor 2A
DNMT1	DNA (cytosine-5-)-methyltransferase 1
HIST2H3C	histone cluster 2, H3c
KAT5	K(lysine) acetyltransferase 5
MPG	N-methylpurine-DNA glycosylase
NRIP1	nuclear receptor interacting protein 1
PDE1A	phosphodiesterase 1A, calmodulin-dependent
PML	promyelocytic leukemia
PPARG	peroxisome proliferator-activated receptor gamma
TP53	tumor protein p53
UHRF1	ubiquitin-like with PHD and ring finger domains 1
UHRF2	ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
UQCC1	ubiquinol-cytochrome c reductase complex assembly factor 1
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)