urapidil-3078 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the urapidil-3078 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACTA2 actin, alpha 2, smooth muscle, aorta
ACVR1B activin A receptor, type IB
ADAM22 ADAM metallopeptidase domain 22
AHSP alpha hemoglobin stabilizing protein
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ASTN2 astrotactin 2
C20ORF27 chromosome 20 open reading frame 27
CCR9 chemokine (C-C motif) receptor 9
CD1E CD1e molecule
CD247 CD247 molecule
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDHR1 cadherin-related family member 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CNGB3 cyclic nucleotide gated channel beta 3
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COL1A1 collagen, type I, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COLEC10 collectin sub-family member 10 (C-type lectin)
COPE coatomer protein complex, subunit epsilon
CTSZ cathepsin Z
DCT dopachrome tautomerase
DICER1 dicer 1, ribonuclease type III
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DOK3 docking protein 3
DSCAM Down syndrome cell adhesion molecule
EEA1 early endosome antigen 1
EHD1 EH-domain containing 1
ELAVL3 ELAV like neuron-specific RNA binding protein 3
EPS8L3 EPS8-like 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBXO40 F-box protein 40
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FGD1 FYVE, RhoGEF and PH domain containing 1
FGF4 fibroblast growth factor 4
FOSL2 FOS-like antigen 2
FST follistatin
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GPATCH4 G patch domain containing 4
GPM6B glycoprotein M6B
GPR15 G protein-coupled receptor 15
GSTA3 glutathione S-transferase alpha 3
HKDC1 hexokinase domain containing 1
ICOSLG inducible T-cell co-stimulator ligand
IDS iduronate 2-sulfatase
ITGB1BP2 integrin beta 1 binding protein (melusin) 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLHL3 kelch-like family member 3
LAMB4 laminin, beta 4
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTBP1 latent transforming growth factor beta binding protein 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MLXIPL MLX interacting protein-like
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MOBP myelin-associated oligodendrocyte basic protein
MTCL1 microtubule crosslinking factor 1
NEBL nebulette
OSBPL10 oxysterol binding protein-like 10
PCLO piccolo presynaptic cytomatrix protein
PEX10 peroxisomal biogenesis factor 10
PLSCR3 phospholipid scramblase 3
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
RASAL2 RAS protein activator like 2
RTEL1 regulator of telomere elongation helicase 1
S100A1 S100 calcium binding protein A1
SEC14L4 SEC14-like 4 (S. cerevisiae)
SERHL2 serine hydrolase-like 2
SIGLEC7 sialic acid binding Ig-like lectin 7
SIX3 SIX homeobox 3
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLN sarcolipin
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SNX24 sorting nexin 24
SPINK5 serine peptidase inhibitor, Kazal type 5
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
SRP72 signal recognition particle 72kDa
STARD5 StAR-related lipid transfer (START) domain containing 5
THBS1 thrombospondin 1
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRBC1 T cell receptor beta constant 1
TRIM31 tripartite motif containing 31
USH1C Usher syndrome 1C (autosomal recessive, severe)
USP29 ubiquitin specific peptidase 29
VGF VGF nerve growth factor inducible
ZER1 zyg-11 related, cell cycle regulator
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF185 zinc finger protein 185 (LIM domain)
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALPK1 alpha-kinase 1
ANO10 anoctamin 10
AOAH acyloxyacyl hydrolase (neutrophil)
APOL6 apolipoprotein L, 6
ASPN asporin
ATF1 activating transcription factor 1
BAHCC1 BAH domain and coiled-coil containing 1
BCCIP BRCA2 and CDKN1A interacting protein
BTF3P12 basic transcription factor 3 pseudogene 12
C11ORF21 chromosome 11 open reading frame 21
C11ORF68 chromosome 11 open reading frame 68
C1QTNF3 C1q and tumor necrosis factor related protein 3
CBR1 carbonyl reductase 1
CD151 CD151 molecule (Raph blood group)
CD1D CD1d molecule
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLEC2D C-type lectin domain family 2, member D
CORO7 coronin 7
CRYBG3 beta-gamma crystallin domain containing 3
DIXDC1 DIX domain containing 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DOLPP1 dolichyldiphosphatase 1
DPY19L2P2 DPY19L2 pseudogene 2
DTX4 deltex 4, E3 ubiquitin ligase
ELP6 elongator acetyltransferase complex subunit 6
EVL Enah/Vasp-like
FAM193B family with sequence similarity 193, member B
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FHOD1 formin homology 2 domain containing 1
FPGS folylpolyglutamate synthase
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPATCH3 G patch domain containing 3
GPR132 G protein-coupled receptor 132
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1B histone cluster 1, H1b
HIST1H2BI histone cluster 1, H2bi
HIST1H2BN histone cluster 1, H2bn
HIST1H3G histone cluster 1, H3g
HYAL3 hyaluronoglucosaminidase 3
IDI2-AS1 IDI2 antisense RNA 1
IRX5 iroquois homeobox 5
ITPKC inositol-trisphosphate 3-kinase C
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIF18A kinesin family member 18A
KIF20A kinesin family member 20A
KPTN kaptin (actin binding protein)
MAGEH1 melanoma antigen family H1
MED15 mediator complex subunit 15
METTL8 methyltransferase like 8
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MKRN3 makorin ring finger protein 3
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MOGS mannosyl-oligosaccharide glucosidase
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL28 mitochondrial ribosomal protein L28
MTMR6 myotubularin related protein 6
MXD3 MAX dimerization protein 3
MYL5 myosin, light chain 5, regulatory
NAG18 NAG18 mRNA
NDE1 nudE neurodevelopment protein 1
NPDC1 neural proliferation, differentiation and control, 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PMCH pro-melanin-concentrating hormone
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PRAF2 PRA1 domain family, member 2
RFTN1 raftlin, lipid raft linker 1
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF25 ring finger protein 25
RPAP1 RNA polymerase II associated protein 1
RPL13P5 ribosomal protein L13 pseudogene 5
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SCGB2A2 secretoglobin, family 2A, member 2
SEC24B SEC24 family member B
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SHPK sedoheptulokinase
SIDT1 SID1 transmembrane family, member 1
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC16A4 solute carrier family 16, member 4
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SPINT1 serine peptidase inhibitor, Kunitz type 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STBD1 starch binding domain 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM8A transmembrane protein 8A
TPM3 tropomyosin 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
USP18 ubiquitin specific peptidase 18
WDR45B WD repeat domain 45B
ZNF85 zinc finger protein 85