urapidil-6696 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the urapidil-6696 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ADARB1 adenosine deaminase, RNA-specific, B1
AKT3 v-akt murine thymoma viral oncogene homolog 3
APAF1 apoptotic peptidase activating factor 1
APC adenomatous polyposis coli
ARSA arylsulfatase A
BATF basic leucine zipper transcription factor, ATF-like
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BMP7 bone morphogenetic protein 7
BTNL3 butyrophilin-like 3
C10ORF12 chromosome 10 open reading frame 12
C1S complement component 1, s subcomponent
CALCA calcitonin-related polypeptide alpha
CASP4 caspase 4, apoptosis-related cysteine peptidase
CC2D1A coiled-coil and C2 domain containing 1A
CISH cytokine inducible SH2-containing protein
CLCN1 chloride channel, voltage-sensitive 1
CLCN4 chloride channel, voltage-sensitive 4
COPE coatomer protein complex, subunit epsilon
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CREBZF CREB/ATF bZIP transcription factor
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTNND2 catenin (cadherin-associated protein), delta 2
CXXC4 CXXC finger protein 4
DGKE diacylglycerol kinase, epsilon 64kDa
DLX4 distal-less homeobox 4
EDIL3 EGF-like repeats and discoidin I-like domains 3
EGR1 early growth response 1
EPHA1 EPH receptor A1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FBXO2 F-box protein 2
FBXO22 F-box protein 22
FGFR1 fibroblast growth factor receptor 1
FLJ22184
FOXG1 forkhead box G1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GATA3 GATA binding protein 3
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPER1 G protein-coupled estrogen receptor 1
GRM8 glutamate receptor, metabotropic 8
GZMM granzyme M (lymphocyte met-ase 1)
HAPLN1 hyaluronan and proteoglycan link protein 1
HAUS5 HAUS augmin-like complex, subunit 5
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HEMK1 HemK methyltransferase family member 1
HFE hemochromatosis
HHAT hedgehog acyltransferase
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HIPK3 homeodomain interacting protein kinase 3
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXC4 homeobox C4
IL6R interleukin 6 receptor
ING4 inhibitor of growth family, member 4
KITLG KIT ligand
KLF12 Kruppel-like factor 12
LAPTM5 lysosomal protein transmembrane 5
LIPG lipase, endothelial
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MC3R melanocortin 3 receptor
MDM4 MDM4, p53 regulator
MEF2D myocyte enhancer factor 2D
MTAP methylthioadenosine phosphorylase
MUSK muscle, skeletal, receptor tyrosine kinase
NDN necdin, melanoma antigen (MAGE) family member
NLE1 notchless homolog 1 (Drosophila)
NTF3 neurotrophin 3
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PAWR PRKC, apoptosis, WT1, regulator
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PTCRA pre T-cell antigen receptor alpha
QPCT glutaminyl-peptide cyclotransferase
RAB3D RAB3D, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
RTEL1 regulator of telomere elongation helicase 1
RUNX1 runt-related transcription factor 1
S100A5 S100 calcium binding protein A5
SIRPA signal-regulatory protein alpha
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SYMPK symplekin
TAOK2 TAO kinase 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TROVE2 TROVE domain family, member 2
UPK1B uroplakin 1B
UTRN utrophin
WDR78 WD repeat domain 78
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZBED4 zinc finger, BED-type containing 4
ZNF219 zinc finger protein 219
ZNF24 zinc finger protein 24
ZNF589 zinc finger protein 589
ZNF639 zinc finger protein 639
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARMCX2 armadillo repeat containing, X-linked 2
BEX1 brain expressed, X-linked 1
BTC betacellulin
C14ORF93 chromosome 14 open reading frame 93
C17ORF70 chromosome 17 open reading frame 70
C5ORF45 chromosome 5 open reading frame 45
C9ORF91 chromosome 9 open reading frame 91
CA11 carbonic anhydrase XI
CCDC88C coiled-coil domain containing 88C
CD68 CD68 molecule
CEL carboxyl ester lipase
CEMIP cell migration inducing protein, hyaluronan binding
CEP131 centrosomal protein 131kDa
CIDEC cell death-inducing DFFA-like effector c
CLIC3 chloride intracellular channel 3
CNTNAP1 contactin associated protein 1
DAGLA diacylglycerol lipase, alpha
DPF3 D4, zinc and double PHD fingers, family 3
EDC4 enhancer of mRNA decapping 4
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
FAM102A family with sequence similarity 102, member A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBRS fibrosin
FBXL7 F-box and leucine-rich repeat protein 7
FKBP1B FK506 binding protein 1B, 12.6 kDa
GMPR guanosine monophosphate reductase
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GSTA3 glutathione S-transferase alpha 3
HIRA histone cell cycle regulator
HIST2H2AA3 histone cluster 2, H2aa3
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IER3IP1 immediate early response 3 interacting protein 1
IFT140 intraflagellar transport 140
IL7 interleukin 7
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KDM8 lysine (K)-specific demethylase 8
KIAA0894 KIAA0894 protein
LINC00472 long intergenic non-protein coding RNA 472
LRRC61 leucine rich repeat containing 61
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAGEF1 melanoma antigen family F1
MCC mutated in colorectal cancers
MED22 mediator complex subunit 22
MFSD11 major facilitator superfamily domain containing 11
MFSD6 major facilitator superfamily domain containing 6
MLYCD malonyl-CoA decarboxylase
MMP9 matrix metallopeptidase 9
MRPS18C mitochondrial ribosomal protein S18C
MYL5 myosin, light chain 5, regulatory
NARFL nuclear prelamin A recognition factor-like
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NRTN neurturin
OSBP2 oxysterol binding protein 2
OSR2 odd-skipped related transciption factor 2
PAIP2B poly(A) binding protein interacting protein 2B
PICK1 protein interacting with PRKCA 1
PID1 phosphotyrosine interaction domain containing 1
PLAG1 pleiomorphic adenoma gene 1
PLCD1 phospholipase C, delta 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POLH polymerase (DNA directed), eta
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PRF1 perforin 1 (pore forming protein)
PRR15L proline rich 15-like
PRSS22 protease, serine, 22
PRSS53 protease, serine, 53
RNF126P1 ring finger protein 126 pseudogene 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STARD5 StAR-related lipid transfer (START) domain containing 5
SYNGR3 synaptogyrin 3
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCEAL2 transcription elongation factor A (SII)-like 2
TESPA1 thymocyte expressed, positive selection associated 1
TEX40 testis expressed 40
TIAM2 T-cell lymphoma invasion and metastasis 2
TIGD6 tigger transposable element derived 6
TMEM121 transmembrane protein 121
TMEM212 transmembrane protein 212
TMSB15A thymosin beta 15a
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRAPPC13 trafficking protein particle complex 13
TSC22D4 TSC22 domain family, member 4
TUBA3D tubulin, alpha 3d
USP27X ubiquitin specific peptidase 27, X-linked
VWA1 von Willebrand factor A domain containing 1
WDR62 WD repeat domain 62
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF215 zinc finger protein 215
ZNF358 zinc finger protein 358
ZNF492 zinc finger protein 492
ZNF552 zinc finger protein 552
ZNF816 zinc finger protein 816
ZSCAN2 zinc finger and SCAN domain containing 2