ursodeoxycholic acid-3105 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the ursodeoxycholic acid-3105 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ANO1 anoctamin 1, calcium activated chloride channel
AQP9 aquaporin 9
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BCR breakpoint cluster region
BTN2A3P butyrophilin, subfamily 2, member A3, pseudogene
C5AR2 complement component 5a receptor 2
C7ORF69 chromosome 7 open reading frame 69
CADM3 cell adhesion molecule 3
CALML3 calmodulin-like 3
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CHMP6 charged multivesicular body protein 6
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CIC capicua transcriptional repressor
CLCA1 chloride channel accessory 1
CLCF1 cardiotrophin-like cytokine factor 1
CNTNAP1 contactin associated protein 1
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL7A1 collagen, type VII, alpha 1
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CXCR3 chemokine (C-X-C motif) receptor 3
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DOHH deoxyhypusine hydroxylase/monooxygenase
E2F5 E2F transcription factor 5, p130-binding
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EPS8L3 EPS8-like 3
ERC2-IT1 ERC2 intronic transcript 1
FN1 fibronectin 1
FSCN3 fascin actin-bundling protein 3, testicular
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GALNT8 polypeptide N-acetylgalactosaminyltransferase 8
GLG1 golgi glycoprotein 1
GP6 glycoprotein VI (platelet)
GRAMD3 GRAM domain containing 3
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HDAC11 histone deacetylase 11
HOXA1 homeobox A1
HOXD11 homeobox D11
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IFNA16 interferon, alpha 16
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6
KCNMB2 potassium channel subfamily M regulatory beta subunit 2
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KLF3 Kruppel-like factor 3 (basic)
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRRC49 leucine rich repeat containing 49
MAP4 microtubule-associated protein 4
MXD1 MAX dimerization protein 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYOZ2 myozenin 2
NBL1 neuroblastoma 1, DAN family BMP antagonist
NELL2 NEL-like 2 (chicken)
NPAS3 neuronal PAS domain protein 3
NPEPL1 aminopeptidase-like 1
NTF3 neurotrophin 3
OGFR opioid growth factor receptor
OR10H1 olfactory receptor, family 10, subfamily H, member 1
PAIP2B poly(A) binding protein interacting protein 2B
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAQR5 progestin and adipoQ receptor family member V
PAX3 paired box 3
PCDH11Y protocadherin 11 Y-linked
PER3 period circadian clock 3
PLA2G1B phospholipase A2, group IB (pancreas)
POU3F4 POU class 3 homeobox 4
PROL1 proline rich, lacrimal 1
PTPRM protein tyrosine phosphatase, receptor type, M
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC39A9 solute carrier family 39, member 9
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SRR serine racemase
ST14 suppression of tumorigenicity 14 (colon carcinoma)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TAAR5 trace amine associated receptor 5
TEAD4 TEA domain family member 4
TICAM1 toll-like receptor adaptor molecule 1
TNK1 tyrosine kinase, non-receptor, 1
TSC22D4 TSC22 domain family, member 4
XCL1 chemokine (C motif) ligand 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZNF280A zinc finger protein 280A
ZNF407 zinc finger protein 407
ZNF446 zinc finger protein 446

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ADAM15 ADAM metallopeptidase domain 15
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
BAHD1 bromo adjacent homology domain containing 1
BIN3 bridging integrator 3
C11ORF68 chromosome 11 open reading frame 68
C7ORF43 chromosome 7 open reading frame 43
CBX7 chromobox homolog 7
CEP97 centrosomal protein 97kDa
CLCN5 chloride channel, voltage-sensitive 5
CLUH clustered mitochondria (cluA/CLU1) homolog
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CXCL2 chemokine (C-X-C motif) ligand 2
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DYSF dysferlin
FAM188A family with sequence similarity 188, member A
FAM222B family with sequence similarity 222, member B
FAM53C family with sequence similarity 53, member C
FAM57A family with sequence similarity 57, member A
FGF22 fibroblast growth factor 22
FHL3 four and a half LIM domains 3
FOXO4 forkhead box O4
FPGS folylpolyglutamate synthase
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
HIST1H1E histone cluster 1, H1e
HIST1H2AJ histone cluster 1, H2aj
HIST1H3G histone cluster 1, H3g
HIST1H4D histone cluster 1, H4d
HRAS Harvey rat sarcoma viral oncogene homolog
HYAL2 hyaluronoglucosaminidase 2
IFI6 interferon, alpha-inducible protein 6
INPPL1 inositol polyphosphate phosphatase-like 1
JAM2 junctional adhesion molecule 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIF13B kinesin family member 13B
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LMBR1L limb development membrane protein 1-like
LRRK1 leucine-rich repeat kinase 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LY6E lymphocyte antigen 6 complex, locus E
LYPLA2P1 lysophospholipase II pseudogene 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
METTL16 methyltransferase like 16
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MPZ myelin protein zero
MRPL2 mitochondrial ribosomal protein L2
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NAT6 N-acetyltransferase 6 (GCN5-related)
NBEAL2 neurobeachin-like 2
NDE1 nudE neurodevelopment protein 1
NECAB3 N-terminal EF-hand calcium binding protein 3
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NIPAL2 NIPA-like domain containing 2
NOD2 nucleotide-binding oligomerization domain containing 2
NOL10 nucleolar protein 10
NT5M 5',3'-nucleotidase, mitochondrial
NXPE3 neurexophilin and PC-esterase domain family, member 3
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PARP11 poly (ADP-ribose) polymerase family, member 11
PCSK7 proprotein convertase subtilisin/kexin type 7
PELP1 proline, glutamate and leucine rich protein 1
PMM1 phosphomannomutase 1
POM121L2 POM121 transmembrane nucleoporin-like 2
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PRDM1 PR domain containing 1, with ZNF domain
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
RAB3D RAB3D, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RNF122 ring finger protein 122
RPP25 ribonuclease P/MRP 25kDa subunit
SEC31B SEC31 homolog B (S. cerevisiae)
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SGPP1 sphingosine-1-phosphate phosphatase 1
SIL1 SIL1 nucleotide exchange factor
SIRT6 sirtuin 6
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBCCD1 TBCC domain containing 1
TESK1 testis-specific kinase 1
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM180 transmembrane protein 180
TMEM184C transmembrane protein 184C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRIM16 tripartite motif containing 16
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UNC13B unc-13 homolog B (C. elegans)
URGCP upregulator of cell proliferation
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
ZBTB3 zinc finger and BTB domain containing 3
ZFAND3 zinc finger, AN1-type domain 3
ZHX2 zinc fingers and homeoboxes 2
ZNF606 zinc finger protein 606
ZNF747 zinc finger protein 747
ZSCAN5A zinc finger and SCAN domain containing 5A