ursodeoxycholic acid-6484 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the ursodeoxycholic acid-6484 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG1 acyl-CoA synthetase bubblegum family member 1
AK2 adenylate kinase 2
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
APOM apolipoprotein M
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
BET1L Bet1 golgi vesicular membrane trafficking protein-like
C19ORF40 chromosome 19 open reading frame 40
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CCDC181 coiled-coil domain containing 181
CD79B CD79b molecule, immunoglobulin-associated beta
CDADC1 cytidine and dCMP deaminase domain containing 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DCAF4 DDB1 and CUL4 associated factor 4
DCTN2 dynactin 2 (p50)
DKKL1 dickkopf-like 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DPYS dihydropyrimidinase
EDA ectodysplasin A
EFS embryonal Fyn-associated substrate
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FBLN1 fibulin 1
FLJ11710 uncharacterized protein FLJ11710
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GUCA2A guanylate cyclase activator 2A (guanylin)
HCAR3 hydroxycarboxylic acid receptor 3
HFE hemochromatosis
HLF hepatic leukemia factor
HOXA10 homeobox A10
HP1BP3 heterochromatin protein 1, binding protein 3
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
HYAL4 hyaluronoglucosaminidase 4
IGFBP5 insulin-like growth factor binding protein 5
JRK Jrk homolog (mouse)
KANK1 KN motif and ankyrin repeat domains 1
KCTD17 potassium channel tetramerization domain containing 17
KRIT1 KRIT1, ankyrin repeat containing
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LPA lipoprotein, Lp(a)
LRRC37A3 leucine rich repeat containing 37, member A3
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MATK megakaryocyte-associated tyrosine kinase
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MPL MPL proto-oncogene, thrombopoietin receptor
MST1 macrophage stimulating 1
MTRF1L mitochondrial translational release factor 1-like
MX2 MX dynamin-like GTPase 2
MYLK myosin light chain kinase
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NHLH1 nescient helix loop helix 1
OCA2 oculocutaneous albinism II
OSBPL10 oxysterol binding protein-like 10
PAWR PRKC, apoptosis, WT1, regulator
PCDHB17P protocadherin beta 17 pseudogene
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PLEK pleckstrin
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
POLL polymerase (DNA directed), lambda
POU4F2 POU class 4 homeobox 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PPP5C protein phosphatase 5, catalytic subunit
PRKCB protein kinase C, beta
PROSC proline synthetase co-transcribed homolog (bacterial)
PYY peptide YY
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RBM12B RNA binding motif protein 12B
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPL18 ribosomal protein L18
RUSC2 RUN and SH3 domain containing 2
SAFB scaffold attachment factor B
SBNO1 strawberry notch homolog 1 (Drosophila)
SCN11A sodium channel, voltage gated, type XI alpha subunit
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SIX1 SIX homeobox 1
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SNAP25 synaptosomal-associated protein, 25kDa
SPRY4 sprouty homolog 4 (Drosophila)
SYNJ1 synaptojanin 1
TEF thyrotrophic embryonic factor
TIMP3 TIMP metallopeptidase inhibitor 3
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPMT thiopurine S-methyltransferase
TRIM2 tripartite motif containing 2
UTS2 urotensin 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WNT6 wingless-type MMTV integration site family, member 6
ZNF222 zinc finger protein 222
ZNF280A zinc finger protein 280A
ZNF551 zinc finger protein 551
ZNF75D zinc finger protein 75D

decreased expression

Symbol Name
ACTL8 actin-like 8
ADGRE5 adhesion G protein-coupled receptor E5
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ANP32A-IT1 ANP32A intronic transcript 1
ANXA1 annexin A1
APLP1 amyloid beta (A4) precursor-like protein 1
ASCC2 activating signal cointegrator 1 complex subunit 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAHD1 bromo adjacent homology domain containing 1
BBC3 BCL2 binding component 3
BIRC7 baculoviral IAP repeat containing 7
C5 complement component 5
C5ORF45 chromosome 5 open reading frame 45
C8ORF60 chromosome 8 open reading frame 60
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCDC186 coiled-coil domain containing 186
CCNO cyclin O
CDH10 cadherin 10, type 2 (T2-cadherin)
CENPO centromere protein O
CFAP44 cilia and flagella associated protein 44
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COQ6 coenzyme Q6 monooxygenase
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEAF1 DEAF1 transcription factor
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNAL4 dynein, axonemal, light chain 4
EAF2 ELL associated factor 2
EMID1 EMI domain containing 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EXD3 exonuclease 3'-5' domain containing 3
FANCE Fanconi anemia, complementation group E
FCHO1 FCH domain only 1
FUZ fuzzy planar cell polarity protein
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GPR87 G protein-coupled receptor 87
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HAMP hepcidin antimicrobial peptide
HIST1H4A histone cluster 1, H4a
HOXA4 homeobox A4
IGFBP6 insulin-like growth factor binding protein 6
IL15RA interleukin 15 receptor, alpha
KAT2A K(lysine) acetyltransferase 2A
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM5C lysine (K)-specific demethylase 5C
KIAA0355 KIAA0355
LAMA3 laminin, alpha 3
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LRP3 low density lipoprotein receptor-related protein 3
MANBA mannosidase, beta A, lysosomal
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAST3 microtubule associated serine/threonine kinase 3
MBIP MAP3K12 binding inhibitory protein 1
MBNL3 muscleblind-like splicing regulator 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NKAIN1 Na+/K+ transporting ATPase interacting 1
NKX3-2 NK3 homeobox 2
NRGN neurogranin (protein kinase C substrate, RC3)
PAQR6 progestin and adipoQ receptor family member VI
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDGFD platelet derived growth factor D
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLD2 phospholipase D2
PTDSS2 phosphatidylserine synthase 2
RAB36 RAB36, member RAS oncogene family
RHBG Rh family, B glycoprotein (gene/pseudogene)
RNF122 ring finger protein 122
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SALL2 spalt-like transcription factor 2
SAYSD1 SAYSVFN motif domain containing 1
SETD1A SET domain containing 1A
SHARPIN SHANK-associated RH domain interactor
SKA1 spindle and kinetochore associated complex subunit 1
SLC12A8 solute carrier family 12, member 8
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNORA21 small nucleolar RNA, H/ACA box 21
SYNC syncoilin, intermediate filament protein
TRDMT1 tRNA aspartic acid methyltransferase 1
TTLL1 tubulin tyrosine ligase-like family member 1
TWF2 twinfilin actin binding protein 2
UNC119 unc-119 homolog (C. elegans)
VAV1 vav 1 guanine nucleotide exchange factor
VIM vimentin
XYLT2 xylosyltransferase II
YIPF5 Yip1 domain family, member 5
ZFAND3 zinc finger, AN1-type domain 3
ZNF623 zinc finger protein 623
ZNF787 zinc finger protein 787
ZNF816 zinc finger protein 816