ursodeoxycholic acid-7243 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the ursodeoxycholic acid-7243 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AK1 adenylate kinase 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ASIC1 acid sensing (proton gated) ion channel 1
ATAD2B ATPase family, AAA domain containing 2B
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BBS7 Bardet-Biedl syndrome 7
BMP2K BMP2 inducible kinase
BTD biotinidase
C7ORF69 chromosome 7 open reading frame 69
C9ORF156 chromosome 9 open reading frame 156
CA11 carbonic anhydrase XI
CASP1 caspase 1, apoptosis-related cysteine peptidase
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP162 centrosomal protein 162kDa
CEP250 centrosomal protein 250kDa
COL6A1 collagen, type VI, alpha 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DAPK3 death-associated protein kinase 3
DMTN dematin actin binding protein
E2F4 E2F transcription factor 4, p107/p130-binding
EGFR epidermal growth factor receptor
FANCF Fanconi anemia, complementation group F
FGFR2 fibroblast growth factor receptor 2
FOXG1 forkhead box G1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GCFC2 GC-rich sequence DNA-binding factor 2
GRSF1 G-rich RNA sequence binding factor 1
IL17RA interleukin 17 receptor A
IL1R2 interleukin 1 receptor, type II
ING1 inhibitor of growth family, member 1
INTS6 integrator complex subunit 6
ITK IL2-inducible T-cell kinase
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LRRC41 leucine rich repeat containing 41
MARS methionyl-tRNA synthetase
MBD3 methyl-CpG binding domain protein 3
MDM1 Mdm1 nuclear protein homolog (mouse)
MED16 mediator complex subunit 16
MID2 midline 2
MPHOSPH9 M-phase phosphoprotein 9
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
NF1 neurofibromin 1
NME5 NME/NM23 family member 5
NPEPL1 aminopeptidase-like 1
NRP1 neuropilin 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PCM1 pericentriolar material 1
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PER3 period circadian clock 3
POLL polymerase (DNA directed), lambda
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PTPRF protein tyrosine phosphatase, receptor type, F
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RARG retinoic acid receptor, gamma
RBBP9 retinoblastoma binding protein 9
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RNFT1 ring finger protein, transmembrane 1
RRBP1 ribosome binding protein 1
RRP1B ribosomal RNA processing 1B
RUFY3 RUN and FYVE domain containing 3
RUNX1 runt-related transcription factor 1
SAP30 Sin3A-associated protein, 30kDa
SCAMP5 secretory carrier membrane protein 5
SCN1B sodium channel, voltage gated, type I beta subunit
SERTAD3 SERTA domain containing 3
SH3GL2 SH3-domain GRB2-like 2
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A44 solute carrier family 25, member 44
SLC38A7 solute carrier family 38, member 7
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLITRK5 SLIT and NTRK-like family, member 5
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMIM8 small integral membrane protein 8
SSBP2 single-stranded DNA binding protein 2
STK16 serine/threonine kinase 16
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TESK2 testis-specific kinase 2
TMEM70 transmembrane protein 70
TOR1AIP1 torsin A interacting protein 1
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TUBA4B tubulin, alpha 4b
UNC45A unc-45 homolog A (C. elegans)
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WIPF1 WAS/WASL interacting protein family, member 1
ZFPL1 zinc finger protein-like 1
ZNF165 zinc finger protein 165
ZNF667 zinc finger protein 667
ZNF675 zinc finger protein 675

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABHD8 abhydrolase domain containing 8
ABI3BP ABI family, member 3 (NESH) binding protein
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAT1 adenosine deaminase, tRNA-specific 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
APLP1 amyloid beta (A4) precursor-like protein 1
ASB7 ankyrin repeat and SOCS box containing 7
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
AXIN1 axin 1
BEX4 brain expressed, X-linked 4
BNC2 basonuclin 2
BRD1 bromodomain containing 1
C11ORF68 chromosome 11 open reading frame 68
C1ORF115 chromosome 1 open reading frame 115
C7ORF43 chromosome 7 open reading frame 43
C8ORF60 chromosome 8 open reading frame 60
CARD8 caspase recruitment domain family, member 8
CCNA1 cyclin A1
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHST10 carbohydrate sulfotransferase 10
CLSPN claspin
CSRNP3 cysteine-serine-rich nuclear protein 3
CXORF56 chromosome X open reading frame 56
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNMBP dynamin binding protein
EML4 echinoderm microtubule associated protein like 4
EN1 engrailed homeobox 1
ERF Ets2 repressor factor
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXL2 F-box and leucine-rich repeat protein 2
FBXO46 F-box protein 46
FIP1L1 factor interacting with PAPOLA and CPSF1
FKBPL FK506 binding protein like
GMIP GEM interacting protein
HIST1H2BI histone cluster 1, H2bi
HMHA1 histocompatibility (minor) HA-1
IL4R interleukin 4 receptor
IL7R interleukin 7 receptor
INF2 inverted formin, FH2 and WH2 domain containing
JUNB jun B proto-oncogene
KIAA0513 KIAA0513
KIAA0753 KIAA0753
KIF15 kinesin family member 15
KLHL26 kelch-like family member 26
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
MAMLD1 mastermind-like domain containing 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAST3 microtubule associated serine/threonine kinase 3
MEIS3P1 Meis homeobox 3 pseudogene 1
MIR22HG MIR22 host gene
MITF microphthalmia-associated transcription factor
MOSPD3 motile sperm domain containing 3
MTG1 mitochondrial ribosome-associated GTPase 1
MTRF1 mitochondrial translational release factor 1
NDE1 nudE neurodevelopment protein 1
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NPR3 natriuretic peptide receptor 3
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OLFML2A olfactomedin-like 2A
OSMR oncostatin M receptor
PARD6A par-6 family cell polarity regulator alpha
PDZD2 PDZ domain containing 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PRICKLE3 prickle homolog 3 (Drosophila)
PTDSS2 phosphatidylserine synthase 2
PTK7 protein tyrosine kinase 7 (inactive)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RANBP17 RAN binding protein 17
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RFX7 regulatory factor X, 7
RNF25 ring finger protein 25
RPL23AP32 ribosomal protein L23a pseudogene 32
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC12A8 solute carrier family 12, member 8
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein
SNTA1 syntrophin, alpha 1
SOBP sine oculis binding protein homolog (Drosophila)
SPEG SPEG complex locus
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STX17 syntaxin 17
SYTL2 synaptotagmin-like 2
TICAM1 toll-like receptor adaptor molecule 1
TIGD6 tigger transposable element derived 6
TMEM121 transmembrane protein 121
TMEM132A transmembrane protein 132A
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSPAN12 tetraspanin 12
TTC26 tetratricopeptide repeat domain 26
TTC4 tetratricopeptide repeat domain 4
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF230 zinc finger protein 230