urticaria Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description Urticaria is a kind of skin rash notable for pale red, raised, itchy bumps that might also cause a burning or stinging sensation. It is often but not necessarily caused by an allergic reaction. (Experimental Factor Ontology, EFO_0005531)
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Genes

260 genes co-occuring with the disease urticaria in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 3.14913
KNG1 kininogen 1 2.51627
ACE angiotensin I converting enzyme 2.30137
C1S complement component 1, s subcomponent 2.22019
F12 coagulation factor XII (Hageman factor) 2.0554
KLKB1 kallikrein B, plasma (Fletcher factor) 1 2.03651
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 1.96848
HRH1 histamine receptor H1 1.80472
C1R complement component 1, r subcomponent 1.6256
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 1.58537
C5AR1 complement component 5a receptor 1 1.57289
CD63 CD63 molecule 1.44123
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 1.41884
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 1.35463
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 1.28304
TPT1 tumor protein, translationally-controlled 1 1.27563
TAC1 tachykinin, precursor 1 1.27563
ALB albumin 1.23082
NLRP3 NLR family, pyrin domain containing 3 1.18324
RNASE3 ribonuclease, RNase A family, 3 1.17292
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.16606
IL1RN interleukin 1 receptor antagonist 1.16136
FOXH1 forkhead box H1 1.11015
MME membrane metallo-endopeptidase 1.08747
PFDN4 prefoldin subunit 4 1.0753
BDKRB2 bradykinin receptor B2 1.03998
CD79A CD79a molecule, immunoglobulin-associated alpha 1.03872
CPN1 carboxypeptidase N, polypeptide 1 1.02988
HNMT histamine N-methyltransferase 0.979689
PFN4 profilin family, member 4 0.978848
PLAT plasminogen activator, tissue 0.931656
PRCP prolylcarboxypeptidase (angiotensinase C) 0.918024
PFN1 profilin 1 0.914727
C4A complement component 4A (Rodgers blood group) 0.913903
PFN2 profilin 2 0.905675
MEFV Mediterranean fever 0.904442
LTC4S leukotriene C4 synthase 0.872872
F11 coagulation factor XI 0.866321
CD4 CD4 molecule 0.856905
NPS neuropeptide S 0.851992
CRP C-reactive protein, pentraxin-related 0.845031
IL5 interleukin 5 0.833558
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.820847
COL24A1 collagen, type XXIV, alpha 1 0.820847
CYSLTR2 cysteinyl leukotriene receptor 2 0.818385
CYSLTR1 cysteinyl leukotriene receptor 1 0.80977
VIT vitrin 0.808129
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.800744
C1QBP complement component 1, q subcomponent binding protein 0.790492
MRGPRX2 MAS-related GPR, member X2 0.781888
ICAM1 intercellular adhesion molecule 1 0.78066
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.770844
SELE selectin E 0.748017
DPP4 dipeptidyl-peptidase 4 0.739488
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.727333
IL31 interleukin 31 0.722886
MASP2 mannan-binding lectin serine peptidase 2 0.716425
HRH2 histamine receptor H2 0.702732
TNF tumor necrosis factor 0.699517
F2 coagulation factor II (thrombin) 0.69751
F3 coagulation factor III (thromboplastin, tissue factor) 0.696707
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.695504
CSN1S1 casein alpha s1 0.687491
KRT1 keratin 1, type II 0.686691
KIAA0101 KIAA0101 0.685091
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.680697
CEP68 centrosomal protein 68kDa 0.673518
SYK spleen tyrosine kinase 0.66199
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.661197
MED28 mediator complex subunit 28 0.648928
MOSPD3 motile sperm domain containing 3 0.64577
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 0.615529
C3 complement component 3 0.606152
KRTAP10-9 keratin associated protein 10-9 0.598351
CCL17 chemokine (C-C motif) ligand 17 0.595233
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 0.585887
ALOX5 arachidonate 5-lipoxygenase 0.581996
BDKRB1 bradykinin receptor B1 0.575383
EPN3 epsin 3 0.569552
NCF4 neutrophil cytosolic factor 4, 40kDa 0.561004
LYZ lysozyme 0.559839
TG thyroglobulin 0.558285
RAX2 retina and anterior neural fold homeobox 2 0.55518
PDCL phosducin-like 0.552463
IGHM immunoglobulin heavy constant mu 0.541992
NRG1 neuregulin 1 0.540055
PLG plasminogen 0.53928
IL4 interleukin 4 0.535409
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 0.533088
HSF4 heat shock transcription factor 4 0.531541
FBXL7 F-box and leucine-rich repeat protein 7 0.51919
C2 complement component 2 0.504207
VCAM1 vascular cell adhesion molecule 1 0.502292
CMA1 chymase 1, mast cell 0.501527
SELPLG selectin P ligand 0.500761
IL6 interleukin 6 0.498467
INPPL1 inositol polyphosphate phosphatase-like 1 0.497703
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.495793
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.495411
ABI3BP ABI family, member 3 (NESH) binding protein 0.485125
IL1B interleukin 1, beta 0.483604
TBXA2R thromboxane A2 receptor 0.483604
ELANE elastase, neutrophil expressed 0.483224
ACRV1 acrosomal vesicle protein 1 0.480566
PDC phosducin 0.479807
POMC proopiomelanocortin 0.465038
CPOX coproporphyrinogen oxidase 0.461639
IL3 interleukin 3 0.460129
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 0.457109
RFXANK regulatory factor X-associated ankyrin-containing protein 0.457109
IGHE immunoglobulin heavy constant epsilon 0.454847
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.45447
CD46 CD46 molecule, complement regulatory protein 0.453716
TPM1 tropomyosin 1 (alpha) 0.451078
HDC histidine decarboxylase 0.447311
FLNA filamin A, alpha 0.447311
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.438282
INA internexin neuronal intermediate filament protein, alpha 0.437154
CFP complement factor properdin 0.432646
SART1 squamous cell carcinoma antigen recognized by T cells 0.431894
HSPG2 heparan sulfate proteoglycan 2 0.425514
EPX eosinophil peroxidase 0.425139
INS insulin 0.424765
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.424389
CFI complement factor I 0.424389
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.42214
CCR3 chemokine (C-C motif) receptor 3 0.420266
KCNK6 potassium channel, two pore domain subfamily K, member 6 0.41727
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.400826
TRPM8 transient receptor potential cation channel, subfamily M, member 8 0.400826
PF4 platelet factor 4 0.394863
SCP2 sterol carrier protein 2 0.393374
MPO myeloperoxidase 0.388538
BICC1 BicC family RNA binding protein 1 0.382966
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.37555
ADAT3 adenosine deaminase, tRNA-specific 3 0.375179
EDC3 enhancer of mRNA decapping 3 0.371847
DSG3 desmoglein 3 0.371847
TPO thyroid peroxidase 0.370737
AADACL3 arylacetamide deacetylase-like 3 0.364824
LAT linker for activation of T cells 0.364454
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.362978
SELL selectin L 0.357814
F9 coagulation factor IX 0.357077
IL2 interleukin 2 0.357077
APP amyloid beta (A4) precursor protein 0.354499
SOD2 superoxide dismutase 2, mitochondrial 0.349717
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.344207
NLRP12 NLR family, pyrin domain containing 12 0.340906
HLA-C major histocompatibility complex, class I, C 0.337242
PGD phosphogluconate dehydrogenase 0.335046
PVALB parvalbumin 0.332121
CD40LG CD40 ligand 0.328469
AHSG alpha-2-HS-glycoprotein 0.321909
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.312827
SUOX sulfite oxidase 0.312464
PGM1 phosphoglucomutase 1 0.311377
PGAP3 post-GPI attachment to proteins 3 0.311014
LALBA lactalbumin, alpha- 0.308118
IGHV3-9 immunoglobulin heavy variable 3-9 0.305948
SSRP1 structure specific recognition protein 1 0.30342
RLN3 relaxin 3 0.302337
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.294413
CECR1 cat eye syndrome chromosome region, candidate 1 0.287952
GLYATL1 glycine-N-acyltransferase-like 1 0.284371
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 0.282225
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 0.280439
MBL2 mannose-binding lectin (protein C) 2, soluble 0.277584
ADORA3 adenosine A3 receptor 0.272241
NGF nerve growth factor (beta polypeptide) 0.271174
VIP vasoactive intestinal peptide 0.264785
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 0.261952
EHF ets homologous factor 0.255241
IL1A interleukin 1, alpha 0.253479
ASRGL1 asparaginase like 1 0.251366
POLK polymerase (DNA directed) kappa 0.250522
CPB2 carboxypeptidase B2 (plasma) 0.249608
REN renin 0.249608
FLAD1 flavin adenine dinucleotide synthetase 1 0.247571
CCL5 chemokine (C-C motif) ligand 5 0.245747
C12ORF57 chromosome 12 open reading frame 57 0.243995
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 0.242245
PRKCQ protein kinase C, theta 0.240148
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 0.23945
PLA2G1B phospholipase A2, group IB (pancreas) 0.238403
SCARF1 scavenger receptor class F, member 1 0.237009
IL18 interleukin 18 0.23492
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 0.234573
PRF1 perforin 1 (pore forming protein) 0.232489
CD5 CD5 molecule 0.227642
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.226607
DEGS1 delta(4)-desaturase, sphingolipid 1 0.223165
SIGLEC8 sialic acid binding Ig-like lectin 8 0.221793
CFB complement factor B 0.22145
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.211934
FIP1L1 factor interacting with PAPOLA and CPSF1 0.211261
SH2D1A SH2 domain containing 1A 0.206913
TPSG1 tryptase gamma 1 0.204263
CD69 CD69 molecule 0.203604
LATS2 large tumor suppressor kinase 2 0.201178
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.200006
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.198064
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.198064
CALCA calcitonin-related polypeptide alpha 0.1936
DCLK3 doublecortin-like kinase 3 0.1936
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 0.192657
DPT dermatopontin 0.192344
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.191408
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.179239
CARD17 caspase recruitment domain family, member 17 0.178682
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.175411
CAT catalase 0.172799
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 0.168854
MVK mevalonate kinase 0.166095
CDH5 cadherin 5, type 2 (vascular endothelium) 0.165874
UROS uroporphyrinogen III synthase 0.165435
RIMS1 regulating synaptic membrane exocytosis 1 0.164359
AMBP alpha-1-microglobulin/bikunin precursor 0.161292
CTSG cathepsin G 0.161139
CRH corticotropin releasing hormone 0.160574
CYGB cytoglobin 0.145506
TRPV3 transient receptor potential cation channel, subfamily V, member 3 0.143336
TRPV2 transient receptor potential cation channel, subfamily V, member 2 0.142815
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.140936
LAP3 leucine aminopeptidase 3 0.140917
RBSN rabenosyn, RAB effector 0.140568
VAV1 vav 1 guanine nucleotide exchange factor 0.140079
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.13998
TCN2 transcobalamin II 0.139257
AANAT aralkylamine N-acetyltransferase 0.139156
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.13908
BLNK B-cell linker 0.138607
CTSE cathepsin E 0.13783
CP ceruloplasmin (ferroxidase) 0.136875
CCR6 chemokine (C-C motif) receptor 6 0.136759
LYN LYN proto-oncogene, Src family tyrosine kinase 0.13668
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.136295
CTSD cathepsin D 0.135999
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.135691
GPR176 G protein-coupled receptor 176 0.135498
HCK HCK proto-oncogene, Src family tyrosine kinase 0.135062
FTH1 ferritin, heavy polypeptide 1 0.135013
FTL ferritin, light polypeptide 0.135013
FGR FGR proto-oncogene, Src family tyrosine kinase 0.134841
LCT lactase 0.134264
CNOT2 CCR4-NOT transcription complex, subunit 2 0.132221
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 0.131573
CCL7 chemokine (C-C motif) ligand 7 0.129921
GUSB glucuronidase, beta 0.12905
SCARB2 scavenger receptor class B, member 2 0.12816
EPHA4 EPH receptor A4 0.127152
CD36 CD36 molecule (thrombospondin receptor) 0.127126
RPS19 ribosomal protein S19 0.127049
EDNRA endothelin receptor type A 0.126228
SCARB1 scavenger receptor class B, member 1 0.124059
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.122134
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 0.121563
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 0.120563
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 0.119468
CCR1 chemokine (C-C motif) receptor 1 0.11806