usp8 Gene Set

Dataset	GeneRIF Biological Term Annotations
Category	structural or functional annotations
Type	biological term
Description	ubiquitin specific peptidase 8\|This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage. This protein is required for the cell to enter the S phase of the cell cycle and also functions as a positive regulator in the Hedgehog signaling pathway in development. Pseudogenes of this gene are present on chromosomes 2 and 6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] (NCBI Entrez Gene Database, 9101)
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Genes

16 genes co-occuring with the biological term usp8 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol	Name
CXCL8	chemokine (C-X-C motif) ligand 8
CXCR4	chemokine (C-X-C motif) receptor 4
EGFR	epidermal growth factor receptor
ERBB3	erb-b2 receptor tyrosine kinase 3
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
LRIG1	leucine-rich repeats and immunoglobulin-like domains 1
MET	MET proto-oncogene, receptor tyrosine kinase
NOD2	nucleotide-binding oligomerization domain containing 2
RNF41	ring finger protein 41, E3 ubiquitin protein ligase
SCNN1A	sodium channel, non voltage gated 1 alpha subunit
SMO	smoothened, frizzled class receptor
TST	thiosulfate sulfurtransferase (rhodanese)
UBE4B	ubiquitination factor E4B
USP8	ubiquitin specific peptidase 8
VPS28	vacuolar protein sorting 28 homolog (S. cerevisiae)
XIAP	X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase