vacuolar lumen Gene Set

Dataset GO Cellular Component Annotations 2025
Category structural or functional annotations
Type cellular component
Description The volume enclosed within the vacuolar membrane. (Gene Ontology, GO_0005775)
External Link http://amigo.geneontology.org/amigo/term/GO:0005775
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Genes

164 proteins localized to the vacuolar lumen cellular component from the curated GO Cellular Component Annotations 2025 dataset.

Symbol Name
ACAN aggrecan
ACD adrenocortical dysplasia homolog (mouse)
ACLY ATP citrate lyase
ACTR10 actin-related protein 10 homolog (S. cerevisiae)
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADA2 adenosine deaminase 2
AGA aspartylglucosaminidase
AGRN agrin
ANKRD44 ankyrin repeat domain 44
ANXA2 annexin A2
APOB apolipoprotein B
ARHGAP45 Rho GTPase activating protein 45
ARSA arylsulfatase A
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP13A2 ATPase type 13A2
AZU1 azurocidin 1
BCAN brevican
BGN biglycan
BPI bactericidal/permeability-increasing protein
C3 complement component 3
C6ORF120 chromosome 6 open reading frame 120
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CBLIF cobalamin binding intrinsic factor
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHID1 chitinase domain containing 1
CPPED1 calcineurin-like phosphoesterase domain containing 1
CREG1 cellular repressor of E1A-stimulated genes 1
CSF3 colony stimulating factor 3 (granulocyte)
CSPG4 chondroitin sulfate proteoglycan 4
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
CTSA cathepsin A
CTSC cathepsin C
CTSD cathepsin D
CTSF cathepsin F
CTSG cathepsin G
CTSK cathepsin K
CTSL cathepsin L
CTSS cathepsin S
CTSV cathepsin V
CUBN cubilin (intrinsic factor-cobalamin receptor)
CYB5R3 cytochrome b5 reductase 3
DCN decorin
DEFA1 defensin, alpha 1
DEFA3 defensin, alpha 3, neutrophil-specific
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DPP7 dipeptidyl-peptidase 7
DSN1 DSN1, MIS12 kinetochore complex component
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EGFL7 EGF-like-domain, multiple 7
ELANE elastase, neutrophil expressed
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAF2 Fas associated factor family member 2
FMOD fibromodulin
FRK fyn-related Src family tyrosine kinase
FTL ferritin, light polypeptide
FUCA1 fucosidase, alpha-L- 1, tissue
FUCA2 fucosidase, alpha-L- 2, plasma
GAA glucosidase, alpha; acid
GALC galactosylceramidase
GALNS galactosamine (N-acetyl)-6-sulfatase
GBA1 glucosylceramidase beta 1
GC group-specific component (vitamin D binding protein)
GCA grancalcin, EF-hand calcium binding protein
GDI2 GDP dissociation inhibitor 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLB1 galactosidase, beta 1
GM2A GM2 ganglioside activator
GNS glucosamine (N-acetyl)-6-sulfatase
GPC1 glypican 1
GPC2 glypican 2
GPC3 glypican 3
GPC4 glypican 4
GPC5 glypican 5
GPC6 glypican 6
GRN granulin
GUSB glucuronidase, beta
GYG1 glycogenin 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HEBP2 heme binding protein 2
HEXA hexosaminidase A (alpha polypeptide)
HEXB hexosaminidase B (beta polypeptide)
HPSE heparanase
HRNR hornerin
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
HSPG2 heparan sulfate proteoglycan 2
IDS iduronate 2-sulfatase
IDUA iduronidase, alpha-L-
IFI30 interferon, gamma-inducible protein 30
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IST1 increased sodium tolerance 1 homolog (yeast)
KERA keratocan
LAMP2 lysosomal-associated membrane protein 2
LGMN legumain
LUM lumican
LYZ lysozyme
MAN2B1 mannosidase, alpha, class 2B, member 1
MAN2B2 mannosidase, alpha, class 2B, member 2
MANBA mannosidase, beta A, lysosomal
MAPK1 mitogen-activated protein kinase 1
MNDA myeloid cell nuclear differentiation antigen
MPO myeloperoxidase
NAAA N-acylethanolamine acid amidase
NAGLU N-acetylglucosaminidase, alpha
NAPRT nicotinate phosphoribosyltransferase
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NCAN neurocan
NEU4 sialidase 4
NHLRC3 NHL repeat containing 3
NPC2 Niemann-Pick disease, type C2
OGN osteoglycin
OMD osteomodulin
ORM2 orosomucoid 2
PA2G4 proliferation-associated 2G4, 38kDa
PADI2 peptidyl arginine deiminase, type II
PLAC8 placenta-specific 8
PLD3 phospholipase D family, member 3
PPT1 palmitoyl-protein thioesterase 1
PPT2 palmitoyl-protein thioesterase 2
PRDX5 peroxiredoxin 5
PRELP proline/arginine-rich end leucine-rich repeat protein
PRKCD protein kinase C, delta
PRSS2 protease, serine, 2 (trypsin 2)
PRSS57 protease, serine, 57
PRTN3 proteinase 3
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PTGES2 prostaglandin E synthase 2
PYCARD PYD and CARD domain containing
PYGB phosphorylase, glycogen; brain
RETN resistin
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASE3 ribonuclease, RNase A family, 3
RNASET2 ribonuclease T2
S100A7 S100 calcium binding protein A7
SCARB2 scavenger receptor class B, member 2
SCGB1D1 secretoglobin, family 1D, member 1
SDC1 syndecan 1
SDC2 syndecan 2
SDC3 syndecan 3
SDC4 syndecan 4
SDCBP syndecan binding protein (syntenin)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFTPA2 surfactant protein A2
SGSH N-sulfoglucosamine sulfohydrolase
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
STK11IP serine/threonine kinase 11 interacting protein
TCN2 transcobalamin II
TINAGL1 tubulointerstitial nephritis antigen-like 1
TOLLIP toll interacting protein
TRAPPC1 trafficking protein particle complex 1
TTR transthyretin
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum)
UNC13D unc-13 homolog D (C. elegans)
VAT1 vesicle amine transport 1
VCAN versican
VCP valosin containing protein
ZNF395 zinc finger protein 395