valdecoxib-6378 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the valdecoxib-6378 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADD2 adducin 2 (beta)
ALDOB aldolase B, fructose-bisphosphate
ANGEL2 angel homolog 2 (Drosophila)
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGAP1 Rho GTPase activating protein 1
ARRB1 arrestin, beta 1
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
BCAN brevican
BLK BLK proto-oncogene, Src family tyrosine kinase
C1QTNF3 C1q and tumor necrosis factor related protein 3
CA5B carbonic anhydrase VB, mitochondrial
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL13 chemokine (C-C motif) ligand 13
CCNK cyclin K
CELF2 CUGBP, Elav-like family member 2
CEP162 centrosomal protein 162kDa
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DNAH9 dynein, axonemal, heavy chain 9
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DTNB dystrobrevin, beta
EGFL7 EGF-like-domain, multiple 7
EMP1 epithelial membrane protein 1
EPX eosinophil peroxidase
ETV1 ets variant 1
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FOSL2 FOS-like antigen 2
FOXG1 forkhead box G1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GGT1 gamma-glutamyltransferase 1
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR3 G protein-coupled receptor 3
HBS1L HBS1-like translational GTPase
HIST1H1T histone cluster 1, H1t
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HNF4A hepatocyte nuclear factor 4, alpha
HOXC11 homeobox C11
HYAL3 hyaluronoglucosaminidase 3
IGFBP7 insulin-like growth factor binding protein 7
IGFLR1 IGF-like family receptor 1
IL1R1 interleukin 1 receptor, type I
IVNS1ABP influenza virus NS1A binding protein
JADE2 jade family PHD finger 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIAA1109 KIAA1109
KRT19P2 keratin 19 pseudogene 2
KRT6B keratin 6B, type II
LATS1 large tumor suppressor kinase 1
LEFTY2 left-right determination factor 2
LOC157562 uncharacterized LOC157562
LYPD1 LY6/PLAUR domain containing 1
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MFAP3 microfibrillar-associated protein 3
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MKL1 megakaryoblastic leukemia (translocation) 1
MRPS18C mitochondrial ribosomal protein S18C
NDRG2 NDRG family member 2
NEK3 NIMA-related kinase 3
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPFFR1 neuropeptide FF receptor 1
OVOL1 ovo-like zinc finger 1
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PDCD2 programmed cell death 2
PDE10A phosphodiesterase 10A
PDGFB platelet-derived growth factor beta polypeptide
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB28 RAB28, member RAS oncogene family
RAB3B RAB3B, member RAS oncogene family
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RARS arginyl-tRNA synthetase
RASL11B RAS-like, family 11, member B
RNF126P1 ring finger protein 126 pseudogene 1
RRBP1 ribosome binding protein 1
S100A12 S100 calcium binding protein A12
SCN3B sodium channel, voltage gated, type III beta subunit
SHANK1 SH3 and multiple ankyrin repeat domains 1
SLC30A10 solute carrier family 30, member 10
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SMC1A structural maintenance of chromosomes 1A
SRPK2 SRSF protein kinase 2
STRN striatin, calmodulin binding protein
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SULT4A1 sulfotransferase family 4A, member 1
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBCD tubulin folding cofactor D
TMEM63A transmembrane protein 63A
TRIM29 tripartite motif containing 29
TTC12 tetratricopeptide repeat domain 12
TTLL7 tubulin tyrosine ligase-like family member 7
UBE3A ubiquitin protein ligase E3A
ZFAND5 zinc finger, AN1-type domain 5
ZNF816 zinc finger protein 816

decreased expression

Symbol Name
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ALOX12 arachidonate 12-lipoxygenase
ALPK1 alpha-kinase 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARID5A AT rich interactive domain 5A (MRF1-like)
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BBC3 BCL2 binding component 3
C1ORF54 chromosome 1 open reading frame 54
C22ORF46 chromosome 22 open reading frame 46
CAMKMT calmodulin-lysine N-methyltransferase
CASC1 cancer susceptibility candidate 1
CD33 CD33 molecule
CD70 CD70 molecule
CERS4 ceramide synthase 4
CLDN9 claudin 9
CLEC7A C-type lectin domain family 7, member A
CNTLN centlein, centrosomal protein
COL21A1 collagen, type XXI, alpha 1
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPLX2 complexin 2
CPPED1 calcineurin-like phosphoesterase domain containing 1
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DPF1 D4, zinc and double PHD fingers family 1
DPF3 D4, zinc and double PHD fingers, family 3
DSCAM Down syndrome cell adhesion molecule
EIF5A2 eukaryotic translation initiation factor 5A2
ERC2 ELKS/RAB6-interacting/CAST family member 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
F2RL3 coagulation factor II (thrombin) receptor-like 3
FLJ22184
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GOLGA6A golgin A6 family, member A
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRM4 glutamate receptor, metabotropic 4
GSTTP1 glutathione S-transferase theta pseudogene 1
HHIPL2 HHIP-like 2
HIST1H2BJ histone cluster 1, H2bj
HIST1H3A histone cluster 1, H3a
HIST1H4A histone cluster 1, H4a
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HPN hepsin
HSPA1L heat shock 70kDa protein 1-like
IFNW1 interferon, omega 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNK5 potassium channel, two pore domain subfamily K, member 5
KRT31 keratin 31, type I
LAX1 lymphocyte transmembrane adaptor 1
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MMP13 matrix metallopeptidase 13
MTSS1L metastasis suppressor 1-like
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NKX3-2 NK3 homeobox 2
ONECUT2 one cut homeobox 2
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OTOR otoraplin
PADI1 peptidyl arginine deiminase, type I
PAQR5 progestin and adipoQ receptor family member V
PAQR6 progestin and adipoQ receptor family member VI
PCDHA9 protocadherin alpha 9
PCDHGA8 protocadherin gamma subfamily A, 8
POPDC2 popeye domain containing 2
PRB3 proline-rich protein BstNI subfamily 3
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RAB36 RAB36, member RAS oncogene family
RAB38 RAB38, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RIMS1 regulating synaptic membrane exocytosis 1
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RND1 Rho family GTPase 1
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RUSC2 RUN and SH3 domain containing 2
RYR1 ryanodine receptor 1 (skeletal)
S1PR1 sphingosine-1-phosphate receptor 1
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TESK2 testis-specific kinase 2
TMEM183A transmembrane protein 183A
TMEM40 transmembrane protein 40
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TSPAN9 tetraspanin 9
TTC21B tetratricopeptide repeat domain 21B
TTN titin
VPS9D1 VPS9 domain containing 1
WDR33 WD repeat domain 33
WT1-AS WT1 antisense RNA
XAF1 XIAP associated factor 1
XDH xanthine dehydrogenase
ZNF428 zinc finger protein 428
ZNF528 zinc finger protein 528
ZNF606 zinc finger protein 606
ZNF671 zinc finger protein 671
ZSCAN2 zinc finger and SCAN domain containing 2