valdecoxib-6408 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the valdecoxib-6408 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGAP10 Rho GTPase activating protein 10
ARHGAP35 Rho GTPase activating protein 35
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BAK1 BCL2-antagonist/killer 1
BTF3P12 basic transcription factor 3 pseudogene 12
C21ORF2 chromosome 21 open reading frame 2
C4ORF29 chromosome 4 open reading frame 29
C5ORF45 chromosome 5 open reading frame 45
CAPN10 calpain 10
CASZ1 castor zinc finger 1
CC2D1A coiled-coil and C2 domain containing 1A
CCHCR1 coiled-coil alpha-helical rod protein 1
CDC14B cell division cycle 14B
CHD3 chromodomain helicase DNA binding protein 3
CHRDL1 chordin-like 1
CISH cytokine inducible SH2-containing protein
CLEC11A C-type lectin domain family 11, member A
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CNOT8 CCR4-NOT transcription complex, subunit 8
CPNE7 copine VII
CRY2 cryptochrome circadian clock 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSF1 colony stimulating factor 1 (macrophage)
ECE1 endothelin converting enzyme 1
EDIL3 EGF-like repeats and discoidin I-like domains 3
ELF4 E74-like factor 4 (ets domain transcription factor)
ELOVL6 ELOVL fatty acid elongase 6
ESR1 estrogen receptor 1
FGFR1 fibroblast growth factor receptor 1
FLOT1 flotillin 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FUZ fuzzy planar cell polarity protein
FZD7 frizzled class receptor 7
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPM6B glycoprotein M6B
HIST1H1D histone cluster 1, H1d
HMGB3P1 high mobility group box 3 pseudogene 1
IFNA14 interferon, alpha 14
INO80D INO80 complex subunit D
IREB2 iron-responsive element binding protein 2
ITGB5 integrin, beta 5
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KRIT1 KRIT1, ankyrin repeat containing
LIME1 Lck interacting transmembrane adaptor 1
LIMK1 LIM domain kinase 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MDFIC MyoD family inhibitor domain containing
MED22 mediator complex subunit 22
MFAP3L microfibrillar-associated protein 3-like
MSL3 male-specific lethal 3 homolog (Drosophila)
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NPR2 natriuretic peptide receptor 2
OCLN occludin
PAIP2B poly(A) binding protein interacting protein 2B
PFDN4 prefoldin subunit 4
PHOX2B paired-like homeobox 2b
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PTK6 protein tyrosine kinase 6
RAB17 RAB17, member RAS oncogene family
RBPMS RNA binding protein with multiple splicing
REM1 RAS (RAD and GEM)-like GTP-binding 1
SAMD9 sterile alpha motif domain containing 9
SBF1 SET binding factor 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SIRT6 sirtuin 6
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMG5 SMG5 nonsense mediated mRNA decay factor
SOCS1 suppressor of cytokine signaling 1
SORBS3 sorbin and SH3 domain containing 3
SPN sialophorin
STAG3 stromal antigen 3
SYNGR1 synaptogyrin 1
TBKBP1 TBK1 binding protein 1
TCP11L1 t-complex 11, testis-specific-like 1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TFDP3 transcription factor Dp family, member 3
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TOR1AIP1 torsin A interacting protein 1
TRAIP TRAF interacting protein
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC22D4 TSC22 domain family, member 4
U2SURP U2 snRNP-associated SURP domain containing
USP34 ubiquitin specific peptidase 34
WDR61 WD repeat domain 61
YY2 YY2 transcription factor
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF428 zinc finger protein 428
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ADGRF1 adhesion G protein-coupled receptor F1
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
AOC2 amine oxidase, copper containing 2 (retina-specific)
ARL15 ADP-ribosylation factor-like 15
ARPIN actin-related protein 2/3 complex inhibitor
ATG10 autophagy related 10
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BST1 bone marrow stromal cell antigen 1
CCDC85C coiled-coil domain containing 85C
CCNO cyclin O
CD80 CD80 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDH7 cadherin 7, type 2
CDK20 cyclin-dependent kinase 20
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLEC2B C-type lectin domain family 2, member B
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CORO2A coronin, actin binding protein, 2A
CRLF1 cytokine receptor-like factor 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DMBT1 deleted in malignant brain tumors 1
DMRT1 doublesex and mab-3 related transcription factor 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DPF1 D4, zinc and double PHD fingers family 1
DPYS dihydropyrimidinase
DRD1 dopamine receptor D1
DSCAM Down syndrome cell adhesion molecule
EFNA3 ephrin-A3
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM120C family with sequence similarity 120C
FLT4 fms-related tyrosine kinase 4
GBA3 glucosidase, beta, acid 3 (gene/pseudogene)
GPR183 G protein-coupled receptor 183
GPR19 G protein-coupled receptor 19
GRIP2 glutamate receptor interacting protein 2
HCG9 HLA complex group 9 (non-protein coding)
HHIPL2 HHIP-like 2
HIST1H1T histone cluster 1, H1t
HIST1H4E histone cluster 1, H4e
HOXC4 homeobox C4
HPS6 Hermansky-Pudlak syndrome 6
IGSF3 immunoglobulin superfamily, member 3
IL17RA interleukin 17 receptor A
IPO8 importin 8
ITK IL2-inducible T-cell kinase
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIAA1462 KIAA1462
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LOC390998 ribosomal protein L10 pseudogene
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAP3K7CL MAP3K7 C-terminal like
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MMP3 matrix metallopeptidase 3
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL44 mitochondrial ribosomal protein L44
MUC3B mucin 3B, cell surface associated
NKX3-2 NK3 homeobox 2
NPM3 nucleophosmin/nucleoplasmin 3
NT5M 5',3'-nucleotidase, mitochondrial
NUP62CL nucleoporin 62kDa C-terminal like
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OSMR oncostatin M receptor
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PICK1 protein interacting with PRKCA 1
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRAF2 PRA1 domain family, member 2
PRB3 proline-rich protein BstNI subfamily 3
PRICKLE3 prickle homolog 3 (Drosophila)
PRR7 proline rich 7 (synaptic)
PRSS22 protease, serine, 22
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNF146 ring finger protein 146
RNF208 ring finger protein 208
RPL13P5 ribosomal protein L13 pseudogene 5
SCN10A sodium channel, voltage gated, type X alpha subunit
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SRD5A3 steroid 5 alpha-reductase 3
STK16 serine/threonine kinase 16
STRA6 stimulated by retinoic acid 6
TAC3 tachykinin 3
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TINAGL1 tubulointerstitial nephritis antigen-like 1
USP6 ubiquitin specific peptidase 6
VNN1 vanin 1
WASF1 WAS protein family, member 1
ZNF415 zinc finger protein 415
ZNF442 zinc finger protein 442
ZNF573 zinc finger protein 573