valproic acid-1150 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the valproic acid-1150 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ABHD6 abhydrolase domain containing 6
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD6 ankyrin repeat domain 6
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BIK BCL2-interacting killer (apoptosis-inducing)
BLVRA biliverdin reductase A
BLVRB biliverdin reductase B
BSPRY B-box and SPRY domain containing
C19ORF66 chromosome 19 open reading frame 66
C7ORF43 chromosome 7 open reading frame 43
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD59 CD59 molecule, complement regulatory protein
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
CHN2 chimerin 2
CPM carboxypeptidase M
CPNE3 copine III
CREB3 cAMP responsive element binding protein 3
CRYZ crystallin, zeta (quinone reductase)
CTSV cathepsin V
DHRS1 dehydrogenase/reductase (SDR family) member 1
DOCK4 dedicator of cytokinesis 4
DSE dermatan sulfate epimerase
DTNA dystrobrevin, alpha
DUSP4 dual specificity phosphatase 4
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA4 ephrin-A4
EXTL2 exostosin-like glycosyltransferase 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGF9 fibroblast growth factor 9
FHL1 four and a half LIM domains 1
FNBP1L formin binding protein 1-like
FOXO1 forkhead box O1
FUCA1 fucosidase, alpha-L- 1, tissue
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GAMT guanidinoacetate N-methyltransferase
GCH1 GTP cyclohydrolase 1
GDAP1 ganglioside induced differentiation associated protein 1
GLRX glutaredoxin (thioltransferase)
GSTA4 glutathione S-transferase alpha 4
HEMK1 HemK methyltransferase family member 1
HOXA1 homeobox A1
ISG20 interferon stimulated exonuclease gene 20kDa
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITSN1 intersectin 1 (SH3 domain protein)
KIAA0753 KIAA0753
MARCKS myristoylated alanine-rich protein kinase C substrate
MAX MYC associated factor X
MOB3B MOB kinase activator 3B
MPZL1 myelin protein zero-like 1
MTUS1 microtubule associated tumor suppressor 1
MYH10 myosin, heavy chain 10, non-muscle
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit
NDNF neuron-derived neurotrophic factor
NIPAL3 NIPA-like domain containing 3
NMRK1 nicotinamide riboside kinase 1
NXPE3 neurexophilin and PC-esterase domain family, member 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCGF2 polycomb group ring finger 2
PCNXL2 pecanex-like 2 (Drosophila)
PDGFRL platelet-derived growth factor receptor-like
PINK1 PTEN induced putative kinase 1
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PLS1 plastin 1
POR P450 (cytochrome) oxidoreductase
PROCR protein C receptor, endothelial
QPCT glutaminyl-peptide cyclotransferase
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAP1GAP RAP1 GTPase activating protein
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RIMS3 regulating synaptic membrane exocytosis 3
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SGPL1 sphingosine-1-phosphate lyase 1
SIDT1 SID1 transmembrane family, member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLITRK5 SLIT and NTRK-like family, member 5
SPINT1 serine peptidase inhibitor, Kunitz type 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STK38L serine/threonine kinase 38 like
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TCF4 transcription factor 4
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TPM1 tropomyosin 1 (alpha)
TPMT thiopurine S-methyltransferase
TPST1 tyrosylprotein sulfotransferase 1
TRIP10 thyroid hormone receptor interactor 10
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
VWA5A von Willebrand factor A domain containing 5A
WLS wntless Wnt ligand secretion mediator
ZC2HC1A zinc finger, C2HC-type containing 1A
ZFYVE16 zinc finger, FYVE domain containing 16
ZSCAN16 zinc finger and SCAN domain containing 16

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACSL5 acyl-CoA synthetase long-chain family member 5
ADGRA3 adhesion G protein-coupled receptor A3
ADI1 acireductone dioxygenase 1
AGO4 argonaute RISC catalytic component 4
AHCTF1 AT hook containing transcription factor 1
ANKRD55 ankyrin repeat domain 55
ANP32A-IT1 ANP32A intronic transcript 1
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARID5A AT rich interactive domain 5A (MRF1-like)
ATAD2B ATPase family, AAA domain containing 2B
BAHCC1 BAH domain and coiled-coil containing 1
BRD9 bromodomain containing 9
C19ORF24 chromosome 19 open reading frame 24
C1ORF123 chromosome 1 open reading frame 123
CARD9 caspase recruitment domain family, member 9
CASD1 CAS1 domain containing 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD14 CD14 molecule
CD320 CD320 molecule
CIDEB cell death-inducing DFFA-like effector b
CISH cytokine inducible SH2-containing protein
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CXORF21 chromosome X open reading frame 21
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DENND2D DENN/MADD domain containing 2D
DHRS3 dehydrogenase/reductase (SDR family) member 3
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DPH2 DPH2 homolog (S. cerevisiae)
ELP6 elongator acetyltransferase complex subunit 6
EML4 echinoderm microtubule associated protein like 4
ERF Ets2 repressor factor
FAM136A family with sequence similarity 136, member A
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FES FES proto-oncogene, tyrosine kinase
FGR FGR proto-oncogene, Src family tyrosine kinase
GPR183 G protein-coupled receptor 183
GTF2I general transcription factor IIi
IGSF6 immunoglobulin superfamily, member 6
JADE1 jade family PHD finger 1
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCTD15 potassium channel tetramerization domain containing 15
KDM5C lysine (K)-specific demethylase 5C
KEAP1 kelch-like ECH-associated protein 1
KLHDC4 kelch domain containing 4
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LAX1 lymphocyte transmembrane adaptor 1
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
METTL1 methyltransferase like 1
MICALL1 MICAL-like 1
MPDU1 mannose-P-dolichol utilization defect 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYL5 myosin, light chain 5, regulatory
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NCF1C neutrophil cytosolic factor 1C pseudogene
NR1D2 nuclear receptor subfamily 1, group D, member 2
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PCOLCE2 procollagen C-endopeptidase enhancer 2
PEF1 penta-EF-hand domain containing 1
PIEZO1 piezo-type mechanosensitive ion channel component 1
PMF1 polyamine-modulated factor 1
PPAN peter pan homolog (Drosophila)
PPCDC phosphopantothenoylcysteine decarboxylase
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PUS1 pseudouridylate synthase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RGS13 regulator of G-protein signaling 13
RGS19 regulator of G-protein signaling 19
SARS2 seryl-tRNA synthetase 2, mitochondrial
SETMAR SET domain and mariner transposase fusion gene
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SLFN12 schlafen family member 12
SNHG3 small nucleolar RNA host gene 3
SUN2 Sad1 and UNC84 domain containing 2
TARP TCR gamma alternate reading frame protein
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TERT telomerase reverse transcriptase
TMEM39B transmembrane protein 39B
UBIAD1 UbiA prenyltransferase domain containing 1
UBTF upstream binding transcription factor, RNA polymerase I
UPB1 ureidopropionase, beta
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZMAT5 zinc finger, matrin-type 5
ZNF32 zinc finger protein 32
ZNF675 zinc finger protein 675
Funding