valproic acid-1222 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the valproic acid-1222 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AFF4 AF4/FMR2 family, member 4
AGFG2 ArfGAP with FG repeats 2
AGO4 argonaute RISC catalytic component 4
ALDOB aldolase B, fructose-bisphosphate
ARMCX2 armadillo repeat containing, X-linked 2
ARTN artemin
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BTBD7 BTB (POZ) domain containing 7
C10ORF10 chromosome 10 open reading frame 10
C21ORF2 chromosome 21 open reading frame 2
CAPN10 calpain 10
CCDC40 coiled-coil domain containing 40
CD40 CD40 molecule, TNF receptor superfamily member 5
CEP164 centrosomal protein 164kDa
CLEC2B C-type lectin domain family 2, member B
CLEC4E C-type lectin domain family 4, member E
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CTAGE5 CTAGE family, member 5
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DXO decapping exoribonuclease
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EDA ectodysplasin A
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ESRRA estrogen-related receptor alpha
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GEMIN7 gem (nuclear organelle) associated protein 7
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRK6 G protein-coupled receptor kinase 6
GSN gelsolin
ICA1 islet cell autoantigen 1, 69kDa
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
ING2 inhibitor of growth family, member 2
JUND jun D proto-oncogene
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KLF4 Kruppel-like factor 4 (gut)
KLHL36 kelch-like family member 36
MAPK3 mitogen-activated protein kinase 3
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MTUS1 microtubule associated tumor suppressor 1
MUC1 mucin 1, cell surface associated
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NELL2 NEL-like 2 (chicken)
NF2 neurofibromin 2 (merlin)
NFIB nuclear factor I/B
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OSR2 odd-skipped related transciption factor 2
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PACS1 phosphofurin acidic cluster sorting protein 1
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PAIP2B poly(A) binding protein interacting protein 2B
PARP3 poly (ADP-ribose) polymerase family, member 3
PCOLCE procollagen C-endopeptidase enhancer
PDGFB platelet-derived growth factor beta polypeptide
PKP3 plakophilin 3
PLD1 phospholipase D1, phosphatidylcholine-specific
PLK3 polo-like kinase 3
PLXNA1 plexin A1
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POM121L2 POM121 transmembrane nucleoporin-like 2
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PVR poliovirus receptor
RAB33A RAB33A, member RAS oncogene family
RGS10 regulator of G-protein signaling 10
RGS4 regulator of G-protein signaling 4
RPL10 ribosomal protein L10
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMG5 SMG5 nonsense mediated mRNA decay factor
SPATA6 spermatogenesis associated 6
ST20 suppressor of tumorigenicity 20
STAT1 signal transducer and activator of transcription 1, 91kDa
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TLE4 transducin-like enhancer of split 4
TRBC1 T cell receptor beta constant 1
USB1 U6 snRNA biogenesis 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAC14 Vac14 homolog (S. cerevisiae)
VWA5A von Willebrand factor A domain containing 5A
WBP4 WW domain binding protein 4
WNT3 wingless-type MMTV integration site family, member 3
ZNF277 zinc finger protein 277
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ACADSB acyl-CoA dehydrogenase, short/branched chain
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANXA2P3 annexin A2 pseudogene 3
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APOLD1 apolipoprotein L domain containing 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BCL9 B-cell CLL/lymphoma 9
BTBD2 BTB (POZ) domain containing 2
C17ORF53 chromosome 17 open reading frame 53
CCDC109B coiled-coil domain containing 109B
CCL20 chemokine (C-C motif) ligand 20
CCP110 centriolar coiled coil protein 110kDa
CDK3 cyclin-dependent kinase 3
CDKL3 cyclin-dependent kinase-like 3
CENPT centromere protein T
CFAP44 cilia and flagella associated protein 44
CHPF chondroitin polymerizing factor
CLCN2 chloride channel, voltage-sensitive 2
CNPY3 canopy FGF signaling regulator 3
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUL9 cullin 9
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
DGKD diacylglycerol kinase, delta 130kDa
DMTN dematin actin binding protein
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
DNM1 dynamin 1
DPH2 DPH2 homolog (S. cerevisiae)
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EFNA3 ephrin-A3
ERAP2 endoplasmic reticulum aminopeptidase 2
ERF Ets2 repressor factor
FAM102A family with sequence similarity 102, member A
FAM222B family with sequence similarity 222, member B
FBXL7 F-box and leucine-rich repeat protein 7
GLS2 glutaminase 2 (liver, mitochondrial)
GMEB1 glucocorticoid modulatory element binding protein 1
HIST1H2AM histone cluster 1, H2am
HOMER2 homer scaffolding protein 2
HOOK1 hook microtubule-tethering protein 1
HOXC13 homeobox C13
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IL17RA interleukin 17 receptor A
IL17RB interleukin 17 receptor B
KLC2 kinesin light chain 2
KPNA5 karyopherin alpha 5 (importin alpha 6)
LARP6 La ribonucleoprotein domain family, member 6
LYPD3 LY6/PLAUR domain containing 3
LZTR1 leucine-zipper-like transcription regulator 1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAGEA6 melanoma antigen family A6
MATN3 matrilin 3
MFGE8 milk fat globule-EGF factor 8 protein
MMP13 matrix metallopeptidase 13
MOGS mannosyl-oligosaccharide glucosidase
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MTERF4 mitochondrial transcription termination factor 4
NDE1 nudE neurodevelopment protein 1
NECAB3 N-terminal EF-hand calcium binding protein 3
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NOL12 nucleolar protein 12
NOTCH1 notch 1
NUBP2 nucleotide binding protein 2
NYNRIN NYN domain and retroviral integrase containing
OCLN occludin
ORAI3 ORAI calcium release-activated calcium modulator 3
PALMD palmdelphin
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PKN1 protein kinase N1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLD2 phospholipase D2
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PMM1 phosphomannomutase 1
PRICKLE3 prickle homolog 3 (Drosophila)
PSKH1 protein serine kinase H1
RANBP17 RAN binding protein 17
RGS17 regulator of G-protein signaling 17
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
SCD5 stearoyl-CoA desaturase 5
SCUBE3 signal peptide, CUB domain, EGF-like 3
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SNPH syntaphilin
THAP7 THAP domain containing 7
THBS3 thrombospondin 3
TMC7 transmembrane channel-like 7
TMEM132A transmembrane protein 132A
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTLL12 tubulin tyrosine ligase-like family member 12
XAB2 XPA binding protein 2
ZNF574 zinc finger protein 574
ZNF629 zinc finger protein 629
ZNF667 zinc finger protein 667
ZNF675 zinc finger protein 675