valproic acid-4433 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the valproic acid-4433 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ACACB acetyl-CoA carboxylase beta
ACTN2 actinin, alpha 2
ADAM12 ADAM metallopeptidase domain 12
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADM2 adrenomedullin 2
AIF1 allograft inflammatory factor 1
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ANKMY1 ankyrin repeat and MYND domain containing 1
ANTXR1 anthrax toxin receptor 1
ATG10 autophagy related 10
BET1L Bet1 golgi vesicular membrane trafficking protein-like
C22ORF46 chromosome 22 open reading frame 46
C2ORF27A chromosome 2 open reading frame 27A
C9ORF9 chromosome 9 open reading frame 9
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CBS cystathionine-beta-synthase
CERS4 ceramide synthase 4
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
COL1A2 collagen, type I, alpha 2
COL7A1 collagen, type VII, alpha 1
CPEB3 cytoplasmic polyadenylation element binding protein 3
CROCCP3 ciliary rootlet coiled-coil, rootletin pseudogene 3
CRY2 cryptochrome circadian clock 2
CT62 cancer/testis antigen 62
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DMP1 dentin matrix acidic phosphoprotein 1
DMRT1 doublesex and mab-3 related transcription factor 1
DNAAF1 dynein, axonemal, assembly factor 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DSCAM Down syndrome cell adhesion molecule
DTNA dystrobrevin, alpha
DUSP26 dual specificity phosphatase 26 (putative)
EGR2 early growth response 2
ELL elongation factor RNA polymerase II
ENOX2 ecto-NOX disulfide-thiol exchanger 2
ESRRG estrogen-related receptor gamma
ETV1 ets variant 1
FAS Fas cell surface death receptor
FGF1 fibroblast growth factor 1 (acidic)
FOXD2 forkhead box D2
GAL3ST4 galactose-3-O-sulfotransferase 4
GLE1 GLE1 RNA export mediator
GLI2 GLI family zinc finger 2
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GYG2 glycogenin 2
H2AFX H2A histone family, member X
HIST1H4F histone cluster 1, H4f
HOXB7 homeobox B7
HOXD11 homeobox D11
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
JAG1 jagged 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KLF6 Kruppel-like factor 6
LDB2 LIM domain binding 2
LINC00312 long intergenic non-protein coding RNA 312
LOX lysyl oxidase
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTK leukocyte receptor tyrosine kinase
MAP2K7 mitogen-activated protein kinase kinase 7
MED16 mediator complex subunit 16
MMP14 matrix metallopeptidase 14 (membrane-inserted)
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NPC1 Niemann-Pick disease, type C1
OLFM1 olfactomedin 1
OR10H1 olfactory receptor, family 10, subfamily H, member 1
PALM paralemmin
PGAM2 phosphoglycerate mutase 2 (muscle)
PGAP3 post-GPI attachment to proteins 3
PLAG1 pleiomorphic adenoma gene 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RBM26 RNA binding motif protein 26
REEP2 receptor accessory protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RUNX1 runt-related transcription factor 1
SCNN1B sodium channel, non voltage gated 1 beta subunit
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPHK2 sphingosine kinase 2
SPN sialophorin
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
STC1 stanniocalcin 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TP73-AS1 TP73 antisense RNA 1
TRIM3 tripartite motif containing 3
TTC21B tetratricopeptide repeat domain 21B
TTLL3 tubulin tyrosine ligase-like family member 3
UNKL unkempt family zinc finger-like

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ADAM23 ADAM metallopeptidase domain 23
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPK1 alpha-kinase 1
ALS2CL ALS2 C-terminal like
ANKH ANKH inorganic pyrophosphate transport regulator
AOC2 amine oxidase, copper containing 2 (retina-specific)
B9D2 B9 protein domain 2
C17ORF53 chromosome 17 open reading frame 53
C1S complement component 1, s subcomponent
CCDC85C coiled-coil domain containing 85C
CD82 CD82 molecule
CFAP45 cilia and flagella associated protein 45
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CIDEC cell death-inducing DFFA-like effector c
CNGB3 cyclic nucleotide gated channel beta 3
CNTLN centlein, centrosomal protein
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DENND2D DENN/MADD domain containing 2D
DEPDC5 DEP domain containing 5
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
FAM188A family with sequence similarity 188, member A
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGF23 fibroblast growth factor 23
FKRP fukutin related protein
FRMD1 FERM domain containing 1
GJA9 gap junction protein, alpha 9, 59kDa
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
H2AFJ H2A histone family, member J
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HHLA1 HERV-H LTR-associating 1
HIST1H4C histone cluster 1, H4c
HLA-DMA major histocompatibility complex, class II, DM alpha
HOXA4 homeobox A4
HOXC5 homeobox C5
HYAL3 hyaluronoglucosaminidase 3
IFI6 interferon, alpha-inducible protein 6
INCENP inner centromere protein antigens 135/155kDa
INPP5J inositol polyphosphate-5-phosphatase J
KLHL29 kelch-like family member 29
LEFTY1 left-right determination factor 1
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LOC729164 hCG1732469
LRRC6 leucine rich repeat containing 6
MED9 mediator complex subunit 9
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MNX1 motor neuron and pancreas homeobox 1
MOCS1 molybdenum cofactor synthesis 1
MTA2 metastasis associated 1 family, member 2
MVD mevalonate (diphospho) decarboxylase
NACA2 nascent polypeptide-associated complex alpha subunit 2
NCALD neurocalcin delta
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PADI2 peptidyl arginine deiminase, type II
PDE12 phosphodiesterase 12
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PLA1A phospholipase A1 member A
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRB3 proline-rich protein BstNI subfamily 3
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RBMS3 RNA binding motif, single stranded interacting protein 3
RNF126P1 ring finger protein 126 pseudogene 1
RPA4 replication protein A4, 30kDa
RPL10L ribosomal protein L10-like
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUSC2 RUN and SH3 domain containing 2
SAYSD1 SAYSVFN motif domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SCML2 sex comb on midleg-like 2 (Drosophila)
SELL selectin L
SETD1A SET domain containing 1A
SETD8 SET domain containing (lysine methyltransferase) 8
SLC22A14 solute carrier family 22, member 14
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLITRK5 SLIT and NTRK-like family, member 5
SLMO1 slowmo homolog 1 (Drosophila)
SMO smoothened, frizzled class receptor
SPINK5 serine peptidase inhibitor, Kazal type 5
STEAP4 STEAP family member 4
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TGFBI transforming growth factor, beta-induced, 68kDa
THRB thyroid hormone receptor, beta
TIAM2 T-cell lymphoma invasion and metastasis 2
TMEM206 transmembrane protein 206
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TUBA4B tubulin, alpha 4b
VN1R1 vomeronasal 1 receptor 1
WDR25 WD repeat domain 25
WDR91 WD repeat domain 91
WNT16 wingless-type MMTV integration site family, member 16
ZBTB33 zinc finger and BTB domain containing 33
ZNF155 zinc finger protein 155
ZNF41 zinc finger protein 41
ZNF480 zinc finger protein 480
ZNF528 zinc finger protein 528